Results 181 to 190 of about 3,220,233 (234)

Push the Limits: Human‐Like Multimodal Extreme Embodied Intelligence for Autonomous Racing

Advanced Robotics Research, EarlyView.
Autonomous racing tests embodied intelligence under extreme control limits of speed, actuation, and decision‐making. Inspired by human multimodality, we present Apex, an embodied agent deployed on a super‐formula racing car at Yas Marina. Integrating physics‐informed perception, multimodal learning, and tasking, Apex cuts lap times by 15% and achieves ...
Yanxin Zhou, Baichuan Lou, Wenhui Huang, Binbin Hu, Haohan Yang, Haochen Liu, Xiangkun He, Chee Kiong Ong, Yiran Zhang, Tianchu Su, Bolin Zhao, Xiaoyu Mo, Holden King Ho Li, Chen Lv   +13 more
wiley   +1 more source

Cell-free DNA fragmentomics and epigenomic profiling in hematologic malignancies: current evidence, translational limitations, and future directions. [PDF]

Transl Oncol
El-Sehrawy AAMA, Abdullah SS, Mamedova G, Rizaev J, Abdelrahim IM, Srivastav SK, Khaleel ZT, Jabir MS, Bainsal N, Smerat A.   +9 more
europepmc   +1 more source

CD9+ B Cells Induce T Follicular Helper Cell Apoptosis to Regulate Germinal Center Regression

Advanced Science, EarlyView.
A unique subset of CD9+ B cells regulates germinal center B (GC‐B) cell regression by inducing T follicular helper (Tfh) cell apoptosis through multiple signaling pathways, such as ALCAM‐CD6. FOXP1 plays a key role in GC‐B cell differentiation. These findings clarify mechanisms of GC degeneration and termination and offer potential targets for adenoid ...
Wenjing Liao, Lijuan Song, Meiqian Xu, Tianhao Liang, Yixuan Chen, Gui Chen, Zaihuan Lin, Huakang Du, Guofei Feng, Zhiming Feng, Qi Zhang, Fan Pan, Saixuan Yang, Xinyin Zhang, Wenxu Peng, Tianlong Li, Zhuoshen Lin, Yabang Chen, Jiayi Liu, Baoxin Peng, Yan Liu, Xing Niu, Ting Li, Chengyu Huang, Ke Mo, Jianlei Xie, Yu Zou, Xiaowen Zhang   +27 more
wiley   +1 more source

Transient ATM inhibition enhances knock-in efficiency in hematopoietic stem cells by attenuating the DNA damage response. [PDF]

Proc Natl Acad Sci U S A
Natsagdorj ME, Hara H, Iida K, Kashiwakura Y, Baatartsogt N, Ganzorig E, Canarutto D, Pinho S, Naldini L, Ohmori T, Hanazono Y, Nakahara F.   +11 more
europepmc   +1 more source

An Anti‐Amyloidogenic Approach to Specifically Block Memory Consolidation in Mice for Therapeutic Intervention

Advanced Science, EarlyView.
Functional amyloid conversion of the translation regulator CPEB3 is essential for long‐term memory persistence. This study demonstrates that targeting this molecular switch with the anti‐amyloidogenic peptide QBP1 selectively blocks CPEB3 fibrillation without disrupting phase separation.
Paula López‐García, Kerry R. McGreevy, Maria Eugenia Vaquero, Juan M. Suarez‐Rivero, Antonio Moreno‐Rodríguez, Antonio J. Pérez‐Pulido, Daniel Ramírez de Mingo, Anna Pallé, Helena Akiko Popiel, Andrea Santi, Mario D. Cordero, José Luis Trejo, Yoshitaka Nagai, Mariano Carrión‐Vázquez   +13 more
wiley   +1 more source

Secondary peripheral T-cell lymphoma in a patient with DLBCL harboring <i>BLM</i> mutation following CD19/CD22 bispecific CAR-T cell therapy. [PDF]

J Immunother Cancer
Liu X, Cong J, Xia X, Wang H, Yu X, Zheng Q, Wang L.   +6 more
europepmc   +1 more source

Dual Role of Tamoxifen in Enhancing STING and CEACAM1 Expression to Prime a Favorable Tumor Microenvironment for Anti‐TIM3 Immunotherapy

Advanced Science, EarlyView.
Anti‐PD‐1/PD‐L1 blockade has revolutionized cancer immunotherapy, but is ineffective against endocrine‐treated (i.e., Tamoxifen), relapsed ER+ breast cancer (BC) patients. This study provides insight into the sub‐optimal response of ER+BCs to anti‐PD‐1/PD‐L1 blockade – highlighting the induction of STING and the CEACAM1/TIM3 axis after chronic ...
Marvin Angelo E Aberin, Saurabh Singh, Soumya Chatterjee, Guang‐Zhi Sui, Yi‐Fu Wang, Ya‐Ting Lu, Yu‐Ling Lee, Kun‐Yuan Lin, Joy Khag, Ta‐Yu Liu, Shao‐Han Chang, Wai‐Mui Cheung, Hsiao‐Chin Hong, Ren‐Jun Hsu, Chen‐Yang Shen, Chia‐Wei Li, Weng‐Lang Yang, Yao‐Ming Chang, Shih‐Yu Chen, Chandan Guha, Shu‐Ping Wang   +20 more
wiley   +1 more source

Spatiotemporal CD8⁺ T-Cell Dynamics: Clonal Replacement and Expansion as Determinants of Sustainable Antitumor Response. [PDF]

Cancer Sci
Ueha S, Aoki H, Takahashi M, Shichino S, Matsushima K.   +4 more
europepmc   +1 more source

Coixenolide Enhances Antitumor Immunity of Cytotoxic CD8+ T Cells by Inhibiting S100A8/A9‐CD36 Axis in Obesity‐Associated Pancreatic Adenocarcinoma

Advanced Science, EarlyView.
Pancreatic adenocarcinoma (PAAD) remains highly lethal with limited treatment options. This study demonstrates that coixenolide, a bioactive compound from Coix lacryma‐jobi L. and a key component of the clinically approved Kanglaite injection, exhibits enhanced antitumor efficacy in high‐fat diet (HFD)‐induced obese mice bearing PAAD tumors compared to
Kaidi Chen, Rong Chen, Wei Li, Bin Song, Ruiying Zhang, Lewei Dai, Yuwei Qi, Ruqian Chen, Yifan Xu, Hangbin Li, Jingyi Huang, Fangping Wu, Jianan Peng, Xinyu Wang, Yang Xiong, Chaofeng Mu, Guilin Cheng, Zhaoshen Li, Shanming Ruan, Lei Huang, Mancang Gu   +20 more
wiley   +1 more source

Adeno-Associated Virus Gene Therapy: Is There a Risk of Insertional Mutagenesis? [PDF]

Toxicol Pathol
Batty P.
europepmc   +1 more source