Results 121 to 130 of about 248,407 (299)

Mycobacterial cell division arrest and smooth‐to‐rough envelope transition using CRISPRi‐mediated genetic repression systems

open access: yesFEBS Open Bio, EarlyView.
CRISPRI‐mediated gene silencing and phenotypic exploration in nontuberculous mycobacteria. In this Research Protocol, we describe approaches to control, monitor, and quantitatively assess CRISPRI‐mediated gene silencing in M. smegmatis and M. abscessus model organisms.
Vanessa Point   +7 more
wiley   +1 more source

Evaluating the impact of modeling the family effect for clonal selection in potato-breeding programs. [PDF]

open access: yesFront Plant Sci, 2023
Martins VS   +11 more
europepmc   +1 more source

Pediatric B cell repertoires are enriched for naive clonal phenotypes and are shaped by distinct selection dynamics

open access: yesFrontiers in Immunology
B cell development in early life sets the stage for how the adaptive immune system will function. Although little is known about B cell biology in children, especially from tissue-residing B cells, it has been previously reported that children generally ...
Thomas Hsiao   +2 more
doaj   +1 more source

Was Dan Janzen (1977) right about aphid clones being a "super-organism", i.e. a single "evolutionary individual"? : new insights from the use of molecular marker systems [PDF]

open access: yes, 2008
Dan Janzen proposed in a paper in 1977 (loc. cit.), that a clone of aphids and for that matter dandelions consists, respectively, of one large ‘super-organism’.
Loxdale, Hugh D.
core  

Tumor‐stromal crosstalk and macrophage enrichment are associated with chemotherapy response in bladder cancer

open access: yesFEBS Open Bio, EarlyView.
Chemoresistance in bladder cancer: Macrophage recruitment associated with CXCL1, CXCL5 and CXCL8 expression is characteristic of Gemcitabine/Cisplatin (Gem/Cis) Non‐Responder tumors (right side) while Responder tumors did not show substantial tumor‐stromal crosstalk (left side). All biological icons are attributed to Bioicons: carcinoma, cancerous‐cell‐
Sophie Leypold   +11 more
wiley   +1 more source

Clonal selection of hematopoietic stem cells after gene therapy for sickle cell disease. [PDF]

open access: yesNat Med, 2023
Spencer Chapman M   +18 more
europepmc   +1 more source

Lineage switch in B-lineage Acute Lymphoblastic Leukemia at relapse: a report

open access: yesPediatric Hematology Oncology Journal
Background: Lineage switch is an uncommon phenomenon at time of relapse and the mechanisms by which this occurs are unclear, but may represent an expanded pre-therapy sub-clone, clonal evolution of the original leukemia, or development of a new clone ...
K Hershavardhini   +2 more
doaj   +1 more source

Route planning of separate waste collection on a small settlement [PDF]

open access: yesTransport Problems, 2014
Waste collection problems are one of the most important logistic tasks to solve. The paper deals with the optimization of vehicle routes, which is one of the ways of reducing costs of waste collection.
Bogna MRÓWCZYŃSKA
doaj  

Microglial dynamics and ferroptosis induction in human iPSC‐derived neuron–astrocyte–microglia tri‐cultures

open access: yesFEBS Open Bio, EarlyView.
A tri‐culture of iPSC‐derived neurons, astrocytes, and microglia treated with ferroptosis inducers as an Induced ferroptosis model was characterized by scRNA‐seq, cell survival, and cytokine release assays. This analysis revealed diverse microglial transcriptomic changes, indicating that the system captures key aspects of the complex cellular ...
Hongmei Lisa Li   +6 more
wiley   +1 more source

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