Results 41 to 50 of about 80,571 (261)

Location-Dependent DNA Methylation Signatures in a Clonal Invasive Crayfish

Frontiers in Cell and Developmental Biology, 2021
DNA methylation is an important epigenetic modification that has been repeatedly implied in organismal adaptation. However, many previous studies that have linked DNA methylation patterns to environmental parameters have been limited by confounding ...
Sina Tönges, Geetha Venkatesh, Ranja Andriantsoa, Katharina Hanna, Fanny Gatzmann, Günter Raddatz, Vitor Coutinho Carneiro, Frank Lyko   +7 more
doaj   +1 more source

Sequence determinants of RNA G‐quadruplex unfolding by Arg‐rich regions

FEBS Letters, EarlyView.
We show that Arg‐rich peptides selectively unfold RNA G‐quadruplexes, but not RNA stem‐loops or DNA/RNA duplexes. This length‐dependent activity is inhibited by acidic residues and is conserved among SR and SR‐related proteins (SRSF1, SRSF3, SRSF9, U1‐70K, and U2AF1).
Naiduwadura Ivon Upekala De Silva, Puspa Kunwar, Md Ibnul Rifat Rahman, Joanna Koryo Kwao, Nathan Lehman, Zihan Zhang, Trenton Paul, Claire Cheng, Nicholas Truex, Hui‐Ting Lee, Jun Zhang   +10 more
wiley   +1 more source

Cell wall target fragment discovery using a low‐cost, minimal fragment library

FEBS Letters, EarlyView.
LoCoFrag100 is a fragment library made up of 100 different compounds. Similarity between the fragments is minimized and 10 different fragments are mixed into a single cocktail, which is soaked to protein crystals. These crystals are analysed by X‐ray crystallography, revealing the binding modes of the bound fragment ligands.
Kaizhou Yan, Mathew Stanley, Olawale Raimi, Andrew T. Ferenbach, Helge C Dorfmueller, Daan M. F. van Aalten   +5 more
wiley   +1 more source

Clonal variation of the basic resistance factors (POD, SOD, CAT, MDA, PRO) in Michelia chapensis

Biologia Plantarum
Michelia chapensis Dandy, a rare and endangered evergreen woody species of the genus Michelia (Magnoliaceae), is endemic to China, with only scattered natural communities (Zhou et al., 2023).
Houyin DENG, HE Jiamin, Rong HUANG, Ruping WEI, Runhui WANG, Su YAN, WU Guandi, Huiquan ZHENG   +7 more
doaj   +1 more source

Stochastic variations of migration speed between cells in clonal populations [PDF]

TECHNOLOGY, 2014
We combined microfluidic tools and molecular probes to monitor the migration speed of successive generations of cancer cells. We found that the migratory speed of individual cells changes stochastically from parent cells to their descendants, while the average speed of successive generations of cells remains constant.
Jun, Yan, Daniel, Irimia
openaire   +2 more sources

Mechanisms of IgE‐mediated food allergy and the role of allergen‐specific B cells

FEBS Letters, EarlyView.
Food allergy arises when allergen‐specific B cells preferentially produce immunoglobulin E (IgE) antibodies against harmless foods. This article explains the mechanisms driving IgE‐mediated reactions, highlights the central role of these B cells, and discusses how natural tolerance (NT) and oral immunotherapy (OIT) can reshape allergic immune responses.
Juan‐Felipe López, Özge Yilmaz Ardicli, Mübeccel Akdis   +2 more
wiley   +1 more source

The planar cell polarity protein Vangl2 interacts with the PDZ‐domains of Scribble but not with a unique PDZ‐like domain in Inturned

FEBS Letters, EarlyView.
Structural and biochemical characterisations show that the planar cell polarity (PCP) protein Inturned harbours a unique PDZ‐like domain that does not bind canonical PDZ‐binding motifs (PBMs) like that of another PCP protein Vangl2. In contrast, the apical‐basal polarity protein Scribble contains four PDZ domains that bind Vangl2, but one PDZ domain ...
Stephan Wilmes, Jan Brysch, Carmen Gelze, Lilli Meier, Daniel Kümmel   +4 more
wiley   +1 more source

Tau acetylation at K331 has limited impact on tau pathology in vivo

FEBS Letters, EarlyView.
We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto, Yukio Matsuba, Mika Takahashi, Takaomi C. Saido   +3 more
wiley   +1 more source

Impact of Hood Steaming on Tuber Vitality of Yellow Nutsedge (Cyperus esculentus)

Agronomy
Cyperus esculentus is a hard-to-control, destructive perennial weed propagating and spreading through rhizomes and tubers. Currently, a combination of mechanical, cultural, and chemical measures sustained over time is required for satisfactory control of
Jeroen Feys, Sander De Ryck, Clara Sciffer, Dirk Reheul, Joos Latré, Danny Callens, Benny De Cauwer   +6 more
doaj   +1 more source

Genome Comparisons of Candida glabrata Serial Clinical Isolates Reveal Patterns of Genetic Variation in Infecting Clonal Populations

Frontiers in Microbiology, 2019
Candida glabrata is an opportunistic fungal pathogen that currently ranks as the second most common cause of candidiasis. Although the mechanisms underlying virulence and drug resistance in C.
Laia Carreté, Laia Carreté, Ewa Ksiezopolska, Ewa Ksiezopolska, Emilia Gómez-Molero, Adela Angoulvant, Adela Angoulvant, Oliver Bader, Cécile Fairhead, Toni Gabaldón, Toni Gabaldón, Toni Gabaldón   +11 more
doaj   +1 more source