Results 51 to 60 of about 80,571 (261)

Streptococcus mutans Clonal Variation Revealed by Multilocus Sequence Typing [PDF]

Journal of Clinical Microbiology, 2007
ABSTRACT Streptococcus mutans is the major pathogen of dental caries, a biofilm-dependent infectious disease, and occasionally causes infective endocarditis. S. mutans strains have been classified into four serotypes ( c , e , f
Kazuhiko, Nakano, Jinthana, Lapirattanakul, Ryota, Nomura, Hirotoshi, Nemoto, Satu, Alaluusua, Lisa, Grönroos, Martti, Vaara, Shigeyuki, Hamada, Takashi, Ooshima, Ichiro, Nakagawa   +9 more
openaire   +2 more sources

Calpain small subunit homodimerization is robust and calcium‐independent

FEBS Letters, EarlyView.
Calpains dimerize via penta‐EF‐hand (PEF) domains. Using single‐molecule force spectroscopy, we measured the strength and kinetics of PEF–PEF homodimer binding. The interaction is robust, shows a transient conformational step before dissociation, and remains largely insensitive to Ca2+.
Nesha May O. Andoy, Trina Dykstra‐MacPherson, Mathias A. Bell, Peter L. Davies, Ruby May A. Sullan   +4 more
wiley   +1 more source

Structural insights into an engineered feruloyl esterase with improved MHET degrading properties

FEBS Letters, EarlyView.
A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa, Konstantinos Makryniotis, Theofani‐Iosifina Sousani, Evangelos Topakas, Vangelis Daskalakis, Maria Dimarogona   +5 more
wiley   +1 more source

Evaluating Clonal Diversity in ‘Merzifon Karası’ (Vitis vinifera) for Yield, Cluster Characteristics, and Millerandage Index

Horticulturae
This study examined clonal variation in Vitis vinifera L. cv. ‘Merzifon Karası’, a Turkish wine grape. Thirty-two clones were evaluated for key growth and enological characteristics, including cluster structure, berry attributes, yield components ...
Kevser Bayram, Bülent Köse, Harlene Hatterman-Valenti   +2 more
doaj   +1 more source

Origin, clonal diversity, and evolution of the parthenogenetic lizard Darevskia unisexualis

BMC Genomics, 2020
Background The hybridization of female D. raddei and male D. valentini gave rise to the parthenogenetic Caucasian rock lizard Darevskia unisexualis. A previously identified genetic polymorphism in the species consisted of one common and two allozyme ...
Andrey A. Vergun, Anastasiya E. Girnyk, Vitaly I. Korchagin, Seraphima K. Semyenova, Marine S. Arakelyan, Felix D. Danielyan, Robert W. Murphy, Alexey P. Ryskov   +7 more
doaj   +1 more source

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

FEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

A methionine‐lined active site governs carbocation stabilization and product specificity in a bacterial terpene synthase

FEBS Letters, EarlyView.
This study reveals a unique active site enriched in methionine residues and demonstrates that these residues play a critical role by stabilizing carbocation intermediates through novel sulfur–cation interactions. Structure‐guided mutagenesis further revealed variants with significantly altered product profiles, enhancing pseudopterosin formation. These
Marion Ringel, Carl P. O. Helmer, Shani Zev, Ronja Driller, Emily Buhr, Markus Reinbold, Renana Schwartz, Gabriel Foley, Mikael Boden, Daniel Garbe, Gerhard Schenk, Dan Thomas Major, Bernhard Loll, Thomas Brück   +13 more
wiley   +1 more source

Flower Position and Clonal Integration Drive Intra-Individual Floral Trait Variation in Water-Hyacinth (Eichhornia crassipes, Pontederiaceae)

Biology
Intra-individual variation in floral traits is linked to plant fitness, playing a central role in sexual selection. This variation can arise from architectural constraints, such as flower position on the inflorescence axis, and from environmental factors.
Guilherme Ramos Demetrio, Luziene Seixas, Flávia de Freitas Coelho   +2 more
doaj   +1 more source

Valosin‐containing protein counteracts ATP‐driven dissolution of FUS condensates through its ATPase activity in vitro

FEBS Letters, EarlyView.
Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura, Shin‐ichi Tate, Kyota Yasuda   +2 more
wiley   +1 more source

Genetic variation for clonal propagation and trait association with field performance in sainfoin

Tropical Grasslands-Forrajes Tropicales, 2016
Clonal plant materials with identical genotypes may be used to precisely detect environmental effects and genotype x environment interactions resulting in a more accurate estimate of genetic parameters in plant genetic analysis.
Sayareh Irani, Mohammad M. Majidi, Aghafakhr Mirlohi   +2 more
doaj   +1 more source