Results 1 to 10 of about 55,715 (309)

Spatial TCR clonality and clonal expansion in the in situ microenvironment of non-small cell lung cancer [PDF]

Journal for ImmunoTherapy of Cancer
Background T-cell activation and clonal expansion are essential to effective immunotherapy responses in non-small cell lung cancer (NSCLC). The distribution of T-cell clones may offer insights into immunogenic mechanisms and imply potential prognostic ...
Mats Nilsson, Hans Brunnström, Patrick Micke, Masafumi Horie, Klas Kärre, Hui Yu, Carina Strell, Rose-Marie Amini, Anastasia Magoulopoulou, Maria Paraskevi Chatzinikolaou, Amanda Lindberg, Artur Mezheyeuski, Max Backman, Johan Botling, Karin Leandersson, Andreas Metousis, Millaray Marincevic, Johanna Sofia Margareta Mattsson   +17 more
doaj   +2 more sources

Diagnosis and Early Prediction of Lymphoma Using High-Throughput Clonality Analysis of Bovine Leukemia Virus-Infected Cells

Microbiology Spectrum, 2022
Bovine leukemia virus (BLV), a retrovirus, infects B cells of ruminants and is integrated into the host genome as a provirus for lifelong infection. After a long latent period, 1% to 5% of BLV-infected cattle develop aggressive lymphoma, enzootic bovine ...
Tomohiro Okagawa, Honami Shimakura, Satoru Konnai, Masumichi Saito, Takahiro Matsudaira, Naganori Nao, Shinji Yamada, Kenji Murakami, Naoya Maekawa, Shiro Murata, Kazuhiko Ohashi   +10 more
doaj   +1 more source

Read the clonotype: Next-generation sequencing-based lymphocyte clonality analysis and perspectives for application in pathology

Frontiers in Oncology, 2023
Clonality assessment using the unique rearrangements of immunoglobulin (IG) and T-cell receptor (TR) genes in lymphocytes is a widely applied supplementary test for the diagnosis of B-cell and T-cell lymphoma.
Patricia J. T. A. Groenen, Patricia J. T. A. Groenen, Michiel van den Brand, Michiel van den Brand, Leonie I. Kroeze, Leonie I. Kroeze, Avital L. Amir, Konnie M. Hebeda   +7 more
doaj   +1 more source

Clonality-climate relationships along latitudinal gradient across China: adaptation of clonality to environments. [PDF]

PLoS ONE, 2014
Plant clonality, the ability of a plant species to reproduce itself vegetatively through ramets (shoot-root units), occurs in many plant species and is considered to be more frequent in cold or wet environments.
Duo Ye, Yukun Hu, Minghua Song, Xu Pan, Xiufang Xie, Guofang Liu, Xuehua Ye, Ming Dong   +7 more
doaj   +1 more source

Aging of the microenvironment influences clonality in hematopoiesis. [PDF]

PLoS ONE, 2012
The mechanisms of the age-associated exponential increase in the incidence of leukemia are not known in detail. Leukemia as well as aging are initiated and regulated in multi-factorial fashion by cell-intrinsic and extrinsic factors. The role of aging of
Virag Vas, Katharina Senger, Karin Dörr, Anja Niebel, Hartmut Geiger   +4 more
doaj   +1 more source

Novel clonality assays for T cell lymphoma in cats targeting the T cell receptor beta, T cell receptor delta, and T cell receptor gamma loci

Journal of Veterinary Internal Medicine, 2021
Background T cell clonality assays in veterinary medicine currently target only the T cell receptor gamma (TRG) locus. Existing assays have suboptimal sensitivity because of insufficient primer coverage of all possible rearrangements.
Araya Radtanakatikanon, Peter F. Moore, Stefan M. Keller, William Vernau   +3 more
doaj   +1 more source

Characteristics of T-Cell Receptor Repertoire and Correlation With EGFR Mutations in All Stages of Lung Cancer

Frontiers in Oncology, 2021
Lung cancer is the leading cause of cancer-related deaths worldwide, and its occurrence is related to the accumulation of gene mutations and immune escape of the tumor.
Huaxia Yang, Yadong Wang, Yadong Wang, Ziqi Jia, Ziqi Jia, Yanyu Wang, Yanyu Wang, Xiaoying Yang, Xiaoying Yang, Pancheng Wu, Pancheng Wu, Yang Song, Huihui Xu, Dejian Gu, Rongrong Chen, Xuefeng Xia, Zhongxing Bing, Chao Gao, Lei Cao, Shanqing Li, Zhili Cao, Naixin Liang   +21 more
doaj   +1 more source

Genome Size, Cytotype Diversity and Reproductive Mode Variation of Cotoneaster integerrimus (Rosaceae) from the Balkans

Plants, 2021
Cotoneaster integerrimus represents a multiploid and facultative apomictic system of widely distributed mountain populations. We used flow cytometry to determine genome size, ploidy level, and reproduction mode variation of the Balkan populations ...
Faruk Bogunić, Sonja Siljak-Yakovlev, Irma Mahmutović-Dizdarević, Alma Hajrudinović-Bogunić, Mickaël Bourge, Spencer C. Brown, Edina Muratović   +6 more
doaj   +1 more source

The Benign Clone Causing Aplastic Anaemia

Thalassemia Reports, 2023
Severe Aplastic Anaemia (SAA) is a rare benign disease but carries a high-mortality rate unless treated in a specialised centre. Overwhelming laboratory and clinical evidence points to an autoimmune pathogenesis; although, the aetiology remains obscure ...
Shaun R. McCann, Andrea Piccin
doaj   +1 more source

Histopathologic, phenotypic, and molecular criteria to discriminate low‐grade intestinal T‐cell lymphoma in cats from lymphoplasmacytic enteritis

Journal of Veterinary Internal Medicine, 2021
Background Differentiation of low‐grade intestinal T‐cell lymphoma (LGITL) from lymphoplasmacytic enteritis (LPE) in cats is a diagnostic challenge for pathologists.
Valérie Freiche, Mathieu V. Paulin, Nathalie Cordonnier, Hélène Huet, Maria‐Elena Turba, Elizabeth Macintyre, Thierry‐Jo Molina, Olivier Hermine, Lucile Couronné, Julie Bruneau   +9 more
doaj   +1 more source