Results 91 to 100 of about 790,447 (335)

By dawn or dusk—how circadian timing rewrites bacterial infection outcomes

FEBS Letters, EarlyView.
The circadian clock shapes immune function, yet its influence on infection outcomes is only beginning to be understood. This review highlights how circadian timing alters host responses to the bacterial pathogens Salmonella enterica, Listeria monocytogenes, and Streptococcus pneumoniae revealing that the effectiveness of immune defense depends not only
Devons Mo, Catherine S. Palmer, Jacqueline M. Kimmey   +2 more
wiley   +1 more source

Clinical correlation and prognostic impact of cytogenetic clone size for myelodysplastic syndromes/neoplasm

Blood Neoplasia
: Most myelodysplastic syndromes/neoplasms (MDS) risk stratification models dichotomize conventional cytogenetic abnormalities into present or absent, neglecting the prognostic impact of clone size (percentage of the total cells/metaphases harboring the ...
Zhuoer Xie, Najla Al Ali, Ling Zhang, Peter Papenhausen, Virginia Olivia Volpe, Onyee Chan, Andrew Kuykendall, Seongseok Yun, Alison Walker, Kendra Sweet, Jeffrey E. Lancet, Eric Padron, David A. Sallman, Rami S. Komrokji   +13 more
doaj   +1 more source

Hematopoietic (stem) cells—The elixir of life?

FEBS Letters, EarlyView.
The aging of HSCs (hematopoietic stem cells) and the blood system leads to the decline of other organs. Rejuvenating aged HSCs improves the function of the blood system, slowing the aging of the heart, kidney, brain, and liver, and the occurrence of age‐related diseases.
Emilie L. Cerezo, Jonah Anderson, Emilie Dinh Vedrenne, Noël Yeh Martín, Jette Lengefeld   +4 more
wiley   +1 more source

HIV Infected T Cells Can Proliferate in vivo Without Inducing Expression of the Integrated Provirus

Frontiers in Microbiology, 2019
BackgroundHIV-1 proviruses can persist during ART in clonally-expanded populations of CD4+ T cells. To date, few examples of an expanded clones containing replication-competent proviruses exist, although it is suspected to be common.
Andrew Musick, Jonathan Spindler, Eli Boritz, Liliana Pérez, Daniel Crespo-Vélez, Sean C. Patro, Michele D. Sobolewski, Michael J. Bale, Carolyn Reid, Brandon F. Keele, Adam Capoferri, Wei Shao, Ann Wiegand, Francesco R. Simonetti, John W. Mellors, Stephen H. Hughes, John M. Coffin, Frank Maldarelli, Mary F. Kearney   +18 more
doaj   +1 more source

T-cell clones in immunoparasitology

Parasitology Today, 1988
Cell-mediated immunity (CMI) is important in many parasitic infections. Stimulation by parasite-specific antigens can induce clonal expansion of parasite-specific T-cells which may act by direct cytotoxic action or by indirect effects on other cells such as natural killer cells or antibody-producing B-cells (Box 1).
Baldwin, C.L., Goddeeris, M., Morrison, W. Ivan   +2 more
openaire   +3 more sources

Phosphatidylinositol 4‐kinase as a target of pathogens—friend or foe?

FEBS Letters, EarlyView.
This graphical summary illustrates the roles of phosphatidylinositol 4‐kinases (PI4Ks). PI4Ks regulate key cellular processes and can be hijacked by pathogens, such as viruses, bacteria and parasites, to support their intracellular replication. Their dual role as essential host enzymes and pathogen cofactors makes them promising drug targets.
Ana C. Mendes, Guilherme M. Azevedo, Amanda P. Barcellos, Diana Bahia   +3 more
wiley   +1 more source

Aldehyde dehydrogenase 1A1 and gelsolin identified as novel invasion-modulating factors in conditioned medium of pancreatic cancer cells [PDF]

, 2008
Conditioned medium (CM) from clonal sub-populations of the pancreatic cancer cell line, MiaPaCa-2 with differing invasive abilities, were examined for their effect on in vitro invasion.
Alban, Albini, Altmeyer, Bendtsen, Bhave, Chaponnier, Collard, Cunningham, Dosaka-Akita, Faivre, Ferlay, Goggins, Han, Holdenrieder, Jelski, Jelski, Jemal, Koya, Kulasingam, Kumar, Kuramitsu, Kwiatkowski, Kwiatkowski, Lee, Lundin, Martin, Martin Clynes, Michael Henry, Moreb, Naomi Walsh, Negm, Ni, Norma O'Donovan, Noske, Okano, Orchekowski, Paul Dowling, Paula Meleady, Safi, Sagawa, Shieh, Sladek, Tanaka, Tanaka, Tanudji, Tempero, Thompson, Thor, Wang, Winston, Yin, Yoshida   +51 more
core   +3 more sources

Structural insights into lacto‐N‐biose I recognition by a family 32 carbohydrate‐binding module from Bifidobacterium bifidum

FEBS Letters, EarlyView.
Bifidobacterium bifidum establishes symbiosis with infants by metabolizing lacto‐N‐biose I (LNB) from human milk oligosaccharides (HMOs). The extracellular multidomain enzyme LnbB drives this process, releasing LNB via its catalytic glycoside hydrolase family 20 (GH20) lacto‐N‐biosidase domain.
Xinzhe Zhang, Naoki Sunagawa, Toma Kashima, Kiyohiko Igarashi, Akimasa Miyanaga, Shinya Fushinobu   +5 more
wiley   +1 more source

Green formulation of copper nanoparticles by Pistacia khinjuk leaf aqueous extract: Introducing a novel chemotherapeutic drug for the treatment of prostate cancer

Open Chemistry
Prostate cancer is a cancer prevalent form characterized by serious clinical symptoms. The discovery of a novel supplement or medication for prostate cancer within the realm of chemotherapeutic drugs holds significant value.
Wang Zhuoqun, Li Ming, Zhang Qi, Xu Lei
doaj   +1 more source

Violation of cell lineage restriction compartments in the chick hindbrain [PDF]

, 1994
Previous cell lineage studies indicate that the repeated neuromeres of the chick hindbrain, the rhombomeres, are cell lineage restriction compartments. We have extended these results and tested if the restrictions are absolute. Two different cell marking
Birgbauer, Eric, Fraser, Scott E.
core