Results 181 to 190 of about 1,253,785 (311)

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

Innovative CRISPR/Cas9-Based Strategy for Allele-Specific HLA Peptidome Analysis Using a Pan-HLA Antibody. [PDF]

Mol Cell Proteomics
Cobos-Figueroa L, Pintor-Poveda A, Mir C, Melamed D, Admon A, Lauzurica P, Lorente E.   +6 more
europepmc   +1 more source

Biological phenotype of human immunodeficiency virus type 1 clones at different stages of infection: progression of disease is associated with a shift from monocytotropic to T-cell-tropic virus population

Journal of Virology, 1992
H. Schuitemaker, M. Koot, A. Neeltje, Kootstra, M. Dercksen, DE RUUDE.Y., Goede, R. P. Steenwijk, J. Lange, J. Schattenkerk, Frank, Miedema, M. Tersmette   +12 more
semanticscholar   +1 more source

Circular RNA expression landscapes in myelodysplastic neoplasms: Associations with mutational signatures and disease progression

Molecular Oncology, EarlyView.
In this explorative study, the abundance of circular RNA molecules in bone marrow stem cells was found to be elevated in patients with high‐risk myelodysplastic neoplasms, and to be associated with an increased risk of progression to acute myeloid leukemia.
Eileen Wedge, Morten Tulstrup, Gabriele Todisco, Pedro Moura, Christophe Côme, Jakob Werner Hansen, Jakob Schmidt Jespersen, Balthasar Schlotmann, Maria Creignou, Mette Dahl, Claudia Schöllkopf, Klas Raaschou‐Jensen, Krister Wennerberg, Bo Porse, Joachim Weischenfeldt, Eva Hellström‐Lindberg, Lasse Sommer Kristensen, Kirsten Grønbæk   +17 more
wiley   +1 more source

A kinetics-based model of haematopoiesis reveals extrinsic regulation of skewed lineage output from stem cells. [PDF]

Nat Cell Biol
Rodríguez-Correa E, Grünschläger F, Nizharadze T, Anstee N, Al-Sabah J, Kumpost V, Sedlmeier A, Li C, Ball M, Fotopoulou F, Jayarajan J, Ghezzi I, Knoch J, Druce M, Aurich K, Büchler-Schäff M, Lux S, Hernández-Malmierca P, Gräsel J, Vonficht D, López-Osias M, González-Saiz E, Fernández-Pérez D, Mathioudaki A, Zaugg J, Rodríguez-Fraticelli A, Mikut R, Trumpp A, Höfer T, Hübschmann D, Haas S, Milsom MD.   +31 more
europepmc   +1 more source

Engineered extracellular vesicles enriched with the miR‐214/199a cluster enhance the efficacy of chemotherapy in ovarian cancer

Molecular Oncology, EarlyView.
Loss of the miR‐214/199a cluster is associated with recurrence in ovarian cancer. Engineered small extracellular vesicles (m214‐sEVs) elevate miR‐214‐3p/miR‐199a‐5p in tumor cells, suppress β‐catenin, TLR4, and YKT6 signaling, reprogram tumor‐derived sEV cargo, reduce chemoresistance and migration, and enhance carboplatin efficacy and survival in ...
Weida Wang, Ayesha Alvero, Yi Qin, Mingjin Wang, Alexandra Fox, Yanfeng Li, Michael Millman, Amy Kemper, Gil Mor, Xian Shuang Liu, Michael Chopp, Zheng Gang Zhang, Yi Zhang   +12 more
wiley   +1 more source

Structural promiscuity in the human circulatory IgA1 clonal repertoire. [PDF]

Proc Natl Acad Sci U S A
Rolland AD, Kalaidopoulou Nteak S, Vidarsson G, Bondt A, Heck AJR.   +4 more
europepmc   +1 more source

Dissemination of New Methicillin-Resistant Staphylococcus aureus Clones in the Community

Journal of Clinical Microbiology, 2002
K. Okuma, K. Iwakawa, J. Turnidge, W. Grubb, J. Bell, F. O'Brien, G. Coombs, J. Pearman, F. Tenover, M. Kapi, C. Tiensasitorn, Teruyo Ito, K. Hiramatsu   +12 more
semanticscholar   +1 more source

IMPDH inhibition enhances cytarabine efficacy in SAMHD1‐expressing leukaemia cells via guanine nucleotide depletion

Molecular Oncology, EarlyView.
Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla, Christopher Dirks, Caroline Eiden, Sonja K. Fesenmayer, Femke M. Hormann, Yolande Klootsema, Ingrid Lilienthal, Si Min Zhang, Nikolas Herold, Sean G. Rudd   +9 more
wiley   +1 more source

Omeprazole activation of CD4+ and CD8+ T-cells through off-target covalent modification of cellular proteins. [PDF]

Toxicol Sci
Grice S, Albashtawy S, Wells G, Hering L, Adair K, Sarsby J, Brownridge P, Ford M, Lloyd R, Hampson L, Wagner A, Sun Y, Liu H, Hammond S, Meng X, Zhang F, Naisbitt D.   +16 more
europepmc   +1 more source