Results 191 to 200 of about 474,905 (265)

In-Vitro Generation of T-Cell Clones to Difluorophenylglyoxal: Implications for Understanding the Immunogenicity of MK-3207. [PDF]

Chem Res Toxicol
Thomson P, Gibson A, Shang J, Meng X, Saville E, Grice S, Ford M, Feng Y, Pearson K, Oropallo M, Gonzalez R, Monroe J, Naisbitt D.   +12 more
europepmc   +1 more source

Targeting the EpCAM‐AXL axis to overcome drug resistance in lung cancer

Molecular Oncology, EarlyView.
Lung cancer cells often evade therapy by hijacking signaling pathways. We reveal that cleaved EpCAM (sEpCAM) stabilizes the oncogenic protein AXL, driving NF‐κB and STAT3‐mediated chemoresistance. This EpCAM‐AXL axis identifies a high‐risk patient subset with poor prognosis.
Alexa Guerrero‐Alba, Mark Shacker, Timothy P. Fleming, Michael A. Smith, Ross M. Bremner, Narendra V. Sankpal   +5 more
wiley   +1 more source

Optimization of antibody binding by adjusting thermodynamic stability during the maturation of antibody affinities. [PDF]

Protein Sci
Akazawa-Ogawa Y, Matsuda T, Kiyose N, Miyazaki N, Fukuta T, Adachi M, Ito Y, Hagihara Y.   +7 more
europepmc   +1 more source

Spatial heterogeneity of hotspot mutations and clonal relatedness in ovarian endometrioid carcinoma

Molecular Oncology, EarlyView.
Spatially resolved analysis revealed heterogeneous distributions of selected cancer‐associated mutations within ovarian endometrioid carcinomas. Shared mutations between paired endometrial and ovarian tumors supported clonal relatedness. These findings highlight the value of sampling multiple tumor regions when interpreting molecular profiles ...
Takahito Ashihara, Kosuke Murakami, Shiro Takamatsu, Akiko Kanto, Seiichi Mori, Tomoyuki Otani, Kazuko Sakai, Yasushi Kotani, Kazuto Nishio, Kaoru Abiko, Noriomi Matsumura   +10 more
wiley   +1 more source

Integrative analysis of the embryonic origin of adult neural stem cells in forebrain subventricular zones. [PDF]

Natl Sci Rev
Wu H, Tang K, Xu R, Li T, Liang K, Wang X, Huang D, Yang Y, Yin Y, Xie J, Li C, Liu X, Bai QR, Wang C, Shen Q, Gao S.   +15 more
europepmc   +1 more source

Automated FRAP microscopy for high‐throughput analysis of protein dynamics in chromatin organization and transcription

FEBS Open Bio, EarlyView.
RoboMic is an automated confocal microscopy pipeline for high‐throughput functional imaging in living cells. Demonstrated with fluorescence recovery after photobleaching (FRAP), it integrates AI‐driven nuclear segmentation, ROI selection, bleaching, and analysis.
Selçuk Yavuz, Bart Geverts, Johan A. Slotman, Andrea Sacchetti, Stefan Prekovic, Martin E. van Royen, Adriaan B. Houtsmuller   +6 more
wiley   +1 more source

ADCK1 Regulates Mitochondrial Bioenergetics in Hepatocellular Carcinoma In Vitro. [PDF]

Int J Mol Sci
Jacquet N, Zhao Y.
europepmc   +1 more source

Raman‐based label‐free microscopic analysis of the pancreas in living zebrafish larvae

FEBS Open Bio, EarlyView.
Forward stimulated Raman scattering (F‐SRS) and epi coherent anti‐Stokes Raman scattering (E‐CARS) allow label‐free discrimination of distinct subcellular structures in the pancreas of living zebrafish larvae. Given the straightforward applicability, we anticipate broad implementation of Raman microscopy in other organs and across various biomedical ...
Noura Faraj, Eline M. F. de Lange, Klaas A. Sjollema, Ben N. G. Giepmans   +3 more
wiley   +1 more source

When to Start, How to Classify, and Whom to Include: A Methodological Assessment and Illustrative Example of the Clone-Censor-Weight Approach for Evaluating Intervention Timing in Observational Studies. [PDF]

Clin Epidemiol
Nicolaisen SK, Thomsen RW, Pedersen L.
europepmc   +1 more source