Results 101 to 110 of about 59,295 (280)

Contribution of Sympathetic Sensory Coupling to Craniofacial Nociception

Orthodontics &Craniofacial Research, EarlyView.
ABSTRACT Stress and anxiety are associated with increased pain intensity in temporomandibular disorders (TMDs) patients. It is possible that this association is due to a direct interaction between the sympathetic and sensory nervous systems. This narrative review examines evidence for a potential sympathetic sensory interaction in deep craniofacial ...
Brian Edwin Cairns
wiley   +1 more source

Intraspinal Drug Delivery Reservoir Refill Procedure by Non-Physician Clinicians: A Nation-Wide Survey of Training, Pocket Fill Experience, and Life-Long Learning Behaviors [PDF]

, 2016
Intraspinal drug delivery (IDD) is a safe and efficacious method used to deliver medications for the treatment of chronic neurologic disease that requires periodic reservoir refills that can place patients at risk for a rare, accidental but potentially ...
McGlothlen, Gail
core   +1 more source

Successful private–public funding of paediatric medicines research: lessons from the EU programme to fund research into off-patent medicines [PDF]

, 2014
The European Paediatric Regulation mandated the European Commission to fund research on off-patent medicines with demonstrated therapeutic interest for children.
Baiardi, P, Bonifazi, D, Bonifazi, F, Ceci, A, Chiron, C, Davies, E H, Eichler, I, Felisi, M, Giannuzzi, V, Giaquinto, C, Jacqz-Aigrain, E, Neubert, A, on behalf of the GRiP Consortium,, Pressler, R, Rabe, H, Ruggieri, L, Turner, M A, Whitaker, M J   +17 more
core   +1 more source

Pharmacokinetic and Pharmacodynamic Modeling of Clonidine and Midazolam for Sedation in Pediatric Intensive Care

Pediatric Anesthesia, EarlyView.
ABSTRACT Background Clonidine and midazolam are routinely used in the pediatric intensive care unit for pain and sedation management, but target concentration and optimal dose are poorly defined for both drugs. The CloSed study is a multicenter, double‐blind, randomized, active‐controlled noninferiority trial with a 1:1 randomization between clonidine ...
Maddlie Bardol, Yucheng Sheng, Manuel Baarslag, Adriana Ceci, Frank Dörje, Mari‐Liis Ilmoja, Peter Larsson, Per‐Arne Lönnqvist, Tuuli Methsvat, Pavla Pokorna, Wolfgang Rascher, Joost van Rosmalen, Michael Schroth, Alessandra Simonetti, Dick Tibboel, Irmgard Toni, Catherine Tuleu, Thomas M. K. Völkl, Brian J. Anderson, Stefan Wimmer, Joseph F. Standing, Antje Neubert, CloSed Consortium   +22 more
wiley   +1 more source

Prediction of the permeability of neutral drugs inferred from their solvation properties [PDF]

, 2015
Determination of drug absorption is an important component of the drug discovery and development process in that it plays a key role in the decision to promote drug candidates to clinical trials.
Milanetti, Edoardo, Raimondo, Domenico, Tramontano, Anna   +2 more
core   +1 more source

The Electronic Faces Thermometer Scale (eFTS)—Construct Validity for Pain Assessment in Pediatric Postoperative Care in Sweden

Pediatric Anesthesia, EarlyView.
ABSTRACT Background Pain in children is undertreated. An assessment scale co‐designed with children, parents, and health care professionals could lead to more effective pain assessments and treatment strategies aimed at reducing pain and pain‐related symptoms.
Angelica Höök, Mia Hylén, Maria Björk, Stefan Nilsson, Jinbing Bai, Henrik Berlin, Helena Hansson, Gudrún Kristjánsdóttir, Rikard Roxner, Pernilla Stenström, Charlotte Castor   +10 more
wiley   +1 more source

A phase II clinical trial to assess the safety of clonidine in acute organophosphorus pesticide poisoning

Trials, 2009
Background An estimated 2–3 million people are acutely poisoned by organophosphorus pesticides each year, mostly in the developing world. There is a pressing need for new affordable antidotes and clonidine has been shown to be effective in animal studies.
Karunatilake Harindra, Abeysinghe Chandana, Hettiarachchi Raja, Jayamanna Shaluka F, Perera Polwattage MS, Dawson Andrew H, Buckley Nick A   +6 more
doaj   +1 more source

Predicting drug penetration across the blood-brain barrier: comparison of different stationary phases for immobilized artificial membrane liquid chromatography [PDF]

, 2014
Several in vitro methods have been tested for their ability to predict drug penetration across the blood-brain barrier into the central nervous system. In this article, the performance of three stationary phases for immobilized artificial membrane (IAM ...
De Vrieze, Mike, Lynen, Frederic, Sandra, Patrick, Szucs, Roman, Verzele, Dieter   +4 more
core  

Mismatch negativity is not correlated with neuroendocrine indicators of catecholaminergic activity in healthy subjects. [PDF]

, 2003
The identification of the brain structures and neurotransmitters responsible for the generation and/or modulation of the mismatch negativity (MMN) may contribute to a clearer understanding of its functional significance, and may have clinical ...
Ansseau, Marc, Couvreur, Anne, Fuchs, Sonia, Hansenne, Michel, Pinto, Emmanuel, Pitchot, William, Reggers, Jean, Scantamburlo, Gabrielle   +7 more
core   +1 more source

Repurposed antihypertensive drugs for negative symptoms in schizophrenia: A systematic review and meta‐analysis

Psychiatry and Clinical Neurosciences, EarlyView.
Schizophrenia is a complex psychiatric disorder characterized by positive, negative, and general psychopathological symptoms. While antipsychotic drugs are effective for positive symptoms, they provide limited benefit for negative symptoms, which are often persistent and strongly associated with functional disability.
Thiago Carnaval, My Bui, Jesús Villoria, Dolores Rodríguez, José Manuel Menchón, Francisco Ciruela, Sebastián Videla   +6 more
wiley   +1 more source