Results 101 to 110 of about 32,465 (232)
European Journal of Pain, Volume 30, Issue 10, November 2026.ABSTRACT Background Major pancreatic surgery is associated with significant postoperative pain that impairs early mobilisation and recovery. ERAS guidelines for pancreaticoduodenectomy recommend multimodal opioid‐sparing analgesia, with a strong recommendation for epidural analgesia and continuous wound infiltration as an alternative.
Caroline D. Lassen +5 more
wiley +1 more source
Attenuating effects of intrathecal clonidine on the exercise pressor reflex
, 1991 We tested the hypothesis that intrathecal injection of clonidine, an alpha 2-adrenergic agonist, attenuated the reflex cardiovascular and ventilatory responses to static muscular contraction in cats. Before clonidine (1 microgram in 0.2 ml), contraction-
J. M. Hill, M. P. Kaufman
core +1 more source
Passionflower in the treatment of opiates withdrawal: a double blind and randomized controled trial
Journal of Medicinal Plants, 2002 Clonidine-base detoxification has been utilized as the main protocol for several years However, detoxification with clondine has its limitation, including lack of efficacy for mental symptoms.
+4 more
doaj
فصلنامه دانشگاه علوم پزشکی جهرم, 2021 Introduction: Postoperative pain is an unpleasant experience. This process causes physiological disorders in all systems of the body. Clonidine as an alpha dual agonist is one of the drugs used to control pain after laparoscopic cholecystectomy ...
Mehrdad Malekshoar +2 more
doaj
Acta Anaesthesiologica Scandinavica, Volume 70, Issue 10, November 2026.ABSTRACT Background Spinal and general anaesthesia seem to lead to similar health‐related outcomes in total knee arthroplasty. However, to produce economically and environmentally sustainable health care, we should also consider other factors. Current guidelines recommend preferring regional anaesthesia and total intravenous anaesthesia to reduce ...
Katarina Lahtinen +2 more
wiley +1 more source
Effects of Clonidine Pretreatment on the Local Anaesthetic Activity of Bupivacaine in Mice
, 1995 This study was designed to document possible changes in bupivacaine local anaesthetic activity in mice after a single injection of clonidine (0.1 or 1 mgkg−1, i.p.).
Laurence Attolini +3 more
core +1 more source
Opioid withdrawal syndrome‐associated cognitive impairment: A narrative review
The American Journal on Addictions, Volume 35, Issue 6, Page 661-672, November 2026.Abstract Background and Objectives Opioid withdrawal syndrome (OWS) comprises a transient constellation of subjective symptoms and objective signs expressed by brain and other organs. Although cognitive impairment is well documented in opioid use and addiction, little is known about cognitive impairment that may specifically accompany OWS.
Faizan Khan +2 more
wiley +1 more source
Circulating catecholamine response to hypoxia and clonidine.
, 2014 Plasma norepinephrine (A) and epinephrine (B) in response to normoxic (FIO2 = 0.21) and hypoxic gas (FIO2 = 0.11) breathing with and without concomitant sympathetic inhibition (48-h transdermal administration of the centrally acting α2-adrenergic ...
Garrett L. Peltonen (531911) +12 more
core +1 more source
Diagnosis and Management of Nitazene Dependence in Sydney, Australia: A Case Series
Drug and Alcohol Review, Volume 45, Issue 7, November 2026.ABSTRACT Introduction Nitazenes are synthetic opioids with potent μ‐receptor activity. There are increasing reports of nitazene overdoses worldwide. We report on a case series of protonitazene and metonitazene dependence responding to high dose medication for the treatment of opioid dependence in both inpatient and outpatient settings.
Daniel Dutkiewicz +6 more
wiley +1 more source
Opioid Modulation of Major Neurotransmitter Systems: Acute, Chronic, and Withdrawal Effects
European Journal of Neuroscience, Volume 64, Issue 9, November 2026.Opioids are widely used but also frequently misused drugs that affect multiple neurotransmitter systems, including dopaminergic, glutamatergic, GABAergic, serotonergic, and cholinergic pathways. Opioid‐induced neuroadaptations depend on the duration of drug exposure, with distinct changes also emerging following drug discontinuation.
Daniela Novakova +2 more
wiley +1 more source