Results 111 to 120 of about 82,588 (312)

A phase II clinical trial to assess the safety of clonidine in acute organophosphorus pesticide poisoning

Trials, 2009
Background An estimated 2–3 million people are acutely poisoned by organophosphorus pesticides each year, mostly in the developing world. There is a pressing need for new affordable antidotes and clonidine has been shown to be effective in animal studies.
Karunatilake Harindra, Abeysinghe Chandana, Hettiarachchi Raja, Jayamanna Shaluka F, Perera Polwattage MS, Dawson Andrew H, Buckley Nick A   +6 more
doaj   +1 more source

Intraspinal Drug Delivery Reservoir Refill Procedure by Non-Physician Clinicians: A Nation-Wide Survey of Training, Pocket Fill Experience, and Life-Long Learning Behaviors [PDF]

, 2016
Intraspinal drug delivery (IDD) is a safe and efficacious method used to deliver medications for the treatment of chronic neurologic disease that requires periodic reservoir refills that can place patients at risk for a rare, accidental but potentially ...
McGlothlen, Gail
core   +1 more source

Guidelines for the Diagnosis and Treatment of Advanced Breast Cancer in China (2024 Edition)

Cancer Innovation, Volume 4, Issue 6, December 2025.
“The core objective of this guideline is to personalize the management of advanced breast cancer through molecular subtyping, optimizing the balance between survival and quality of life. We integrate recent evidence‐based advances and underscore the essential roles of multidisciplinary collaboration and management of patient‐reported outcomes (PROs ...
Breast Cancer Expert Committee of the National Quality Control Center for Cancer, Breast Cancer Expert Committee of the China Anti‐Cancer Association, Cancer Drug Clinical Research Committee of the China Anti‐Cancer Association   +2 more
wiley   +1 more source

Intrathecal clonidine for perioperative pain relief in abdominal hysterectomy

Indian Journal of Pain, 2013
Background: Two different doses of intrathecal clonidine with hyperbaric bupivacaine fentanyl combination is compared in women undergoing abdominal hysterectomy to get best beneficial effects with minimal incidence of side effects/complications. Methods:
Debjyoti Dutta, Chhandasi Naskar, Rita Wahal, V K Bhatia, Vinita Singh   +4 more
doaj   +1 more source

Predicting drug penetration across the blood-brain barrier: comparison of different stationary phases for immobilized artificial membrane liquid chromatography [PDF]

, 2014
Several in vitro methods have been tested for their ability to predict drug penetration across the blood-brain barrier into the central nervous system. In this article, the performance of three stationary phases for immobilized artificial membrane (IAM ...
De Vrieze, Mike, Lynen, Frederic, Sandra, Patrick, Szucs, Roman, Verzele, Dieter   +4 more
core  

Clinical Pharmacogenetics Implementation Consortium Guideline for NAT2 Genotype and Hydralazine Therapy

Clinical Pharmacology &Therapeutics, Volume 118, Issue 6, Page 1430-1436, December 2025.
Hydralazine is a vasodilator typically used in the treatment of resistant hypertension and heart failure. N‐acetyltransferase 2 (NAT2) catalyzes the metabolism of hydralazine into inactive metabolites. NAT2 poor metabolizers (historically referred to as “slow acetylators”) are predicted to have increased plasma hydralazine concentrations compared with ...
Michael T. Eadon, David W. Hein, Michael A. Andersen, Arlene B. Chapman, Rhonda M. Cooper‐DeHoff, Zeruesenay Desta, Julio D. Duarte, Amanda L. Elchynski, Andrea Gaedigk, Seth E. Karol, Nita A. Limdi, Christelle Lteif, Laura Sosinski, Pablo Zubiaur, Michelle Whirl‐Carrillo, Teri E. Klein, Kelly E. Caudle, Roseann S. Donnelly, José A.G. Agúndez   +18 more
wiley   +1 more source

Quality of Postoperative Pain Management after Midfacial Fracture Repair—An Outcome-oriented Study [PDF]

, 2015
Objectives There is a lack of literature regarding the procedure-specific quality of acute postoperative pain management after midfacial fracture repair.
Djedovic, Gabriel, Gomez-Dammeier, Marta, Guentsch, Arndt, Meissner, Winfried, Peisker, Andre, Raschke, Gregor F., Rieger, Ulrich M., Schaefer, Oliver, Venth, Eric   +8 more
core   +2 more sources

Prediction of the permeability of neutral drugs inferred from their solvation properties [PDF]

, 2015
Determination of drug absorption is an important component of the drug discovery and development process in that it plays a key role in the decision to promote drug candidates to clinical trials.
Milanetti, Edoardo, Raimondo, Domenico, Tramontano, Anna   +2 more
core   +1 more source

Effects of Clonidine Premedication Upon Postoperative Shivering and Recovery Time in Patients With and Without Opium Addiction After Elective Leg Fracture Surgeries

Anesthesiology and Pain Medicine, 2012
Background Opium is a highly addictive agent and the most common narcotic often misused in Iran. The pharmacokinetic of anesthetic drugs in patients with opium addiction is one of the great challenges for anesthesiologists.
Morteza Jabbary Moghaddam, D. Ommi, A. Mirkheshti, A. Dabbagh, Elham Memary, A. Sadeghi, M. Yaseri   +6 more
semanticscholar   +1 more source

Biochemical Diagnosis of Phaeochromocytoma and Paraganglioma in Children and Adolescents: A Retrospective Cohort Study

Clinical Endocrinology, Volume 103, Issue 6, Page 787-794, December 2025.
ABSTRACT Introduction Currently, it is unclear whether plasma free or 24‐h urinary fractionated metanephrines are preferable for diagnosis of phaeochromocytoma/paraganglioma (PPGL) in children. Objectives To investigate whether measurements of plasma free and 24‐h urinary fractionated metanephrines are reliable tests for screening for PPGL in children.
Kristin Potthoff, Tamara Prodanov, Lara M. Knigge, Angela Hübner, Stefan Bornstein, Jacques Lenders, Karel Pacak, Graeme Eisenhofer, Christina Pamporaki   +8 more
wiley   +1 more source