Results 121 to 130 of about 59,295 (280)

Angiotensin AT1 – α2C-adrenoceptor interaction disturbs α2A-auto-inhibition of catecholamine release in hypertensive rats [PDF]

open access: yes, 2013
α2-Adrenoceptors lower central sympathetic output and peripheral catecholamine release, and thus may prevent sympathetic hyperactivity and hypertension. α2AR also influence vascular tension.
Berg, Torill
core   +2 more sources

Modulation of the Neurovascular Unit by the Locus Coeruleus–Norepinephrine System: From Physiological Mechanisms to Therapeutic Applications

open access: yesThe FASEB Journal, Volume 39, Issue 20, 31 October 2025.
The locus coeruleus (LC)–norepinephrine (NE) system significantly influences the structure and function of the neurovascular unit (NVU). The activation degree and firing patterns of LC–NE neurons, as well as the release amount and action sites of NE, profoundly impact the neurons, glial cells, and cerebrovascular components of the NVU.
Zixin Pan   +7 more
wiley   +1 more source

Pharmacological and non-pharmacological treatments for the Neonatal Abstinence Syndrome (NAS). [PDF]

open access: yes, 2019
Neonatal abstinence syndrome is defined by signs and symptoms of withdrawal that infants develop after intrauterine maternal drug exposure. All infants with documented in utero opioid exposure, or a high pre-test probability of exposure should have ...
Kraft, W. K.   +2 more
core   +1 more source

Pseudo-obstruction due to clonidine. [PDF]

open access: bronze, 1976
Robert A. Bear, Keith Steer
openalex   +1 more source

Solvent‐Free Mechanocatalytic Reduction of Nitro Compounds with Hydrogen Gas and its Application in the Synthesis of Drugs and their Intermediates

open access: yesAdvanced Synthesis &Catalysis, Volume 367, Issue 19, October 15, 2025.
A solvent‐free mechanochemical reduction of nitro compounds using hydrogen gas is presented. In addition to enabling the synthesis of a variety of functionalized aniline derivatives, the method has been scaled up to gram quantities, evaluated for trace metal impurities, and applied to the synthesis of pharmaceutical compounds and their precursors.
Samarth Bhatnagar   +2 more
wiley   +1 more source

Cardiovascular Disease Meets Cancer: Exploring the Epidemiology in China and Homotherapy Targeting Intersectional Mechanisms

open access: yesAdvanced Science, Volume 12, Issue 37, October 6, 2025.
Cardiovascular disease (CVD) and cancer are leading causes of death worldwide, with overlapping risk factors and pathophysiological mechanisms. This review explores shared pathways, including metabolic dysregulation, chronic inflammation, and gut microbiome alterations, highlighting dual‐benefit strategies such as lifestyle modifications and repurposed
Shihan Xiang   +6 more
wiley   +1 more source

Functional bowel disease : a challenging frontier in gastroenterology [PDF]

open access: yes, 1999
The last 30 years have seen incredible advances in the science and practice of gastroenterology and hepatology. In the 1970s, the fiberoptic endoscopic revolution facilitated the visualization of the mucosa of a large segment of the gastrointestinal ...
Camilleri, Michael
core  

EFFECT OF CLONIDINE ON THE EXCITABILITY OF VASOMOTOR LOCI IN THE CAT [PDF]

open access: green, 1975
B. N. Dhawan   +4 more
openalex   +1 more source

Secular Trends in the Use of Valproate‐Containing Medicines in Women of Childbearing Age in Europe: A Multinational DARWIN EU Network Study

open access: yesPharmacoepidemiology and Drug Safety, Volume 34, Issue 10, October 2025.
ABSTRACT Background Valproate‐containing medicines (VPA) are first‐line treatments for epilepsy; however, they pose teratogenic risks, restricting their use in women of childbearing age. We aimed to estimate the secular trends in the use of VPA and alternative treatments in young women, and to characterise dose/strength, treatment duration, and ...
Lucía Bellas   +14 more
wiley   +1 more source

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