Results 211 to 220 of about 759,664 (294)

In vitro programmable DNA cleavage by a eukaryotic Argonaute. [PDF]

Nucleic Acids Res
Yan G, Yan G, Li X, Wang L, Wang F, Lv S, Yu X, Li Z, Cui J, Sun B, Hou J, Li W, Xie X, Zhao S, Zhang Z, Chen W, Peng Y, Liu Y, Ma L.   +18 more
europepmc   +1 more source

Covalent Binding of Dexamethasone to Polyimide Improves Biocompatibility of Neural Implantable Devices

Advanced Healthcare Materials, EarlyView.
The covalent binding of dexamethasone to the surface of polyimide represents the electrically inert part of implantable intraneural devices. This ensures a sustained release of the drug for 9 weeks. In vitro and in vivo tests confirm the reduction of the foreign body reactions and the improved biocompatibility of dexamethasone functionalized polyimide.
Giulia Turrin, Jose Crugeiras, Chiara Bisquoli, Davide Barboni, Martina Catani, Bruno Rodríguez‐Meana, Rita Boaretto, Michele Albicini, Stefano Caramori, Claudio Trapella, Thomas Stieglitz, Yara Baslan, Hanna Karlsson‐Fernberg, Fernanda L. Narvaez‐Chicaiza, Edoardo Marchini, Alberto Cavazzini, Ruben López‐Vales, Maria Asplund, Xavier Navarro, Stefano Carli   +19 more
wiley   +1 more source

Cas9 endonuclease: a molecular tool for <i>in vitro</i> cloning and CRISPR edit detection. [PDF]

Front Genome Ed
Ma X, Kthiri D, Gill MS, Pozniak CJ, Kagale S.   +4 more
europepmc   +1 more source

Vorticity‐Facilitated Platelet Aggregation: a High Expansion‐Ratio Stenotic Microfluidic Platform Unravels the Role of Complex Flow Dynamics in Arterial Thrombosis

Advanced Healthcare Materials, EarlyView.
This study reveals how vorticity—a swirling flow pattern—enhances platelet aggregation and thrombus formation in high‐shear conditions. Using a custom microfluidic model, it is shows that vorticity promotes vWF–GPIbα interactions and calcium signaling, providing new insights into thrombosis mechanobiology and informing safer blood‐contacting medical ...
Jianfang Ren, Nurul Aisha Zainal Abidin, Allan Sun, Rui Gao, Yuxin Chen, Arian Nasser, Zihao Wang, Yunduo Charles Zhao, Alexander Dupuy, Anna Waterhouse, Qian Peter Su, Daniele Vigolo, Mike Chia Lun Wu, Lining Arnold Ju   +13 more
wiley   +1 more source

Immuno-informatics analyses of important esophageal cancer associated viruses for multi-epitope vaccine design. [PDF]

Front Immunol
Shehri ZSA.
europepmc   +1 more source

Combination of Polydopamine and Plasma Oxidation to Increase Tissue Integration of Polyurethane‐Silicone Copolymers for Cardiovascular Implants

Advanced Healthcare Materials, EarlyView.
Plasma oxidation following polydopamine deposition can significantly reduce the surface hydrophobicity of polyurethane‐siloxanes without impacting surface roughness, thereby increasing fibroblast viability, adhesion, and extracellular matrix production and secretion.
Sophie Armstrong, Jennifer M. Dyson, Lingxiao Zeng, Saeedreza Zeibi Shirejini, John S. Forsythe, Shaun D. Gregory   +5 more
wiley   +1 more source

Identification and characterization of DFR gene family and cloning of candidate genes for anthocyanin biosynthesis in pepper (Capsicum annuum L.). [PDF]

BMC Plant Biol
An Y, Li N, Zhang R, Wang S, Wang J.
europepmc   +1 more source

Nanobody‐Decorated Lipid Nanoparticles for Enhanced mRNA Delivery to Tumors In Vivo

Advanced Healthcare Materials, EarlyView.
This study presents a targeted mRNA‐LNP platform engineered with anti‐PSMA nanobodies for prostate cancer therapy. Using different in vivo models, the authors demonstrate selective uptake and mRNA delivery in PSMA+ cancer cells. However, while targeting is enhanced, mRNA delivery efficacy is limited by tissue penetration, tumor necrosis, and immune ...
Pol Escudé Martinez de Castilla, Vincenzo Verdi, Willemijn de Voogt, Mariona Estapé Sentí, Arnold C. Koekman, Julian Rietveld, Sven van Kempen, Qiangbing Yang, Juliette van Merris, Guido Jenster, Martin E. van Royen, Marcel H. Fens, Sander A. A. Kooijmans, Wytske M. van Weerden, Guillaume van Niel, Pieter Vader, Raymond M. Schiffelers   +16 more
wiley   +1 more source

The first thermophilic phage display system. [PDF]

Mater Today Bio
Skowron PM, Sobolewski I, Adamowicz K, Morcinek-Orłowska J, Gaffke L, Jaroszewicz W, Łubkowska B, Pierzynowska K, Zylicz-Stachula A, Węgrzyn G.   +9 more
europepmc   +1 more source

Pulmonary Delivery of siRNA Anti‐TNFα‐loaded Lipid Nanoparticles for Rapid Recovery in Murine Acute Lung Injury

Advanced Healthcare Materials, EarlyView.
In a murine model of acute lung injury, pulmonary administration of lipid nanoparticles carrying TNFα siRNA enables targeted delivery to immune cells. The study emphasises the importance of optimizing LNP distribution and delivery timing to improve therapeutic outcomes and develop emergency therapies for lung hyperinflammation.
Qinglin Wang, Jihana Achour, Laila Emam, Younes Louaguenouni, Catherine Cailleau, Françoise Mercier‐Nomé, Séverine Domenichini, Claudine Delomenie, Sezen Gul, Juliette Vergnaud, Nicolas Tsapis, Arnaud Mansart, Djillali Annane, Francois Fay, Elias Fattal   +14 more
wiley   +1 more source