Results 81 to 90 of about 3,939,762 (298)
Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment
Molecular Oncology, EarlyView.This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley +1 more source
Human Cloning Public Policy Issues. National Academy of Sciences Forum (2001 August 7) (Part 3)
, 2001 "Professors talked about the ethics of human cloning for both therapeutic and reproductive reasons. Among the topics they addressed were methods of cloning, potential dangers involved, and potential benefits of cloning.
Producer: National Cable Satellite Corporation
core
Molecular Oncology, EarlyView.In this explorative study, the abundance of circular RNA molecules in bone marrow stem cells was found to be elevated in patients with high‐risk myelodysplastic neoplasms, and to be associated with an increased risk of progression to acute myeloid leukemia.
Eileen Wedge +17 more
wiley +1 more source
, 2006 Foreword -- Introduction -- Ch. 1. Should reproductive cloning be pursued? -- 1. Reproductive cloning is ethical / Gregory E. Pence -- 2. Reproductive cloning is unethical / Peter J. Cataldo -- 3.
Gerdes, Louise, ed.
core +2 more sources
Human Reproductive Cloning. National Academy of Sciences Forum (2001 August 7) (Part 2)
, 2001 "In sometimes heated exchanges, a panel of experts [NAS Public Panel on Human Reproductive Cloning] questioned scientists about their plans to begin human cloning research. Among the issues addressed were ethical concerns, the safety of cloning research,
Producer: National Cable Satellite Corporation. C-SPAN
core
Molecular Oncology, EarlyView.Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla +9 more
wiley +1 more source
Hijacking emergency granulopoiesis: Neutrophil ontogeny and reprogramming in cancer
Molecular Oncology, EarlyView.Neutrophils are highly plastic innate immune cells; their functions in cancer extend beyond the tumour microenvironment. This Review summarises current understanding of neutrophil maturation and heterogeneity and highlights tumour‐induced granulopoiesis as a systemic programme that expands immature, immunosuppressive neutrophils via tumour‐derived ...
Gabriela Marinescu, Yi Feng
wiley +1 more source
Animal and Human Cloning Data. National Academy of Sciences Forum (2001 August 7) (Part 5)
, 2001 "Dr. Wilmut discussed the applicabilty of animal cloning data to human cloning. He was the scientist who cloned the sheep "Dolly" in Scotland. Dr. Van Steirteghem reviewed assisted reproductive technology in humans. Dr.
Producer: National Cable Satellite Corporation
core
Molecular Oncology, EarlyView.Combining osimertinib with the STING agonist ADU‐S100 activates innate and adaptive immunity to overcome the non‐inflamed microenvironment of Egfr‐mutant lung cancer. This combination increases NK and CD8+ T‐cell infiltration, associated with activation of the STING‐IRF3 pathway and local immunogenic cell death.
Jun Nishimura +19 more
wiley +1 more source
Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining
Molecular Oncology, EarlyView.IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis +3 more
wiley +1 more source