Results 201 to 210 of about 1,771,671 (365)

The molecular genetics of RASopathies: An update on novel disease genes and new disorders

American Journal of Medical Genetics Part C: Seminars in Medical Genetics, Volume 190, Issue 4, Page 425-439, December 2022., 2022
Abstract Enhanced signaling through RAS and the mitogen‐associated protein kinase (MAPK) cascade underlies the RASopathies, a family of clinically related disorders affecting development and growth. In RASopathies, increased RAS‐MAPK signaling can result from the upregulated activity of various RAS GTPases, enhanced function of proteins positively ...
Marco Tartaglia, Yoko Aoki, Bruce D. Gelb   +2 more
wiley   +1 more source

Diagnostic dilemma: application of real-time PCR assays for the detection of Dientamoeba fragilis in medical and veterinary specimens. [PDF]

Parasit Vectors
Hall LM, Ellis JT, Stark DJ.
europepmc   +1 more source

Isoform discovery by targeted cloning, 'deep-well' pooling and parallel sequencing

Nature Methods, 2008
K. Salehi-Ashtiani, Xinping Yang, A. Derti, Weidong Tian, Tong Hao, Chenwei Lin, K. Makowski, Lei Shen, Ryan R. Murray, D. Szeto, N. Tusneem, Douglas R. Smith, M. Cusick, D. Hill, F. Roth, M. Vidal   +15 more
semanticscholar   +1 more source

Cloning Endangered Animal Species? [PDF]

, 2011
Blomquist, Robert F.
core   +1 more source

Reshape the Fates of Treg and CD8+T Cells Through IL‐2Rα by Synergizing Divergent Receptor‐Biased IL‐2 PEGylates

Advanced Science, EarlyView.
This study presents receptor‐biased IL‐2 PEGylates that selectively modulate IL‐2 receptor subunit interactions to enhance CD8⁺ T cell antitumor activity while curbing Treg activation and endothelial toxicity. The combined not‐α and not‐β variants balance immune stimulation and prevent T cell exhaustion, offering a novel, fine‐tuned approach for ...
Jiaqi Sun, Lingfeng Guo, Dezhong Ji, Mengfan Yu, Boyang Cheng, Xingxing Zhu, Yeshuang Yuan, Siyu Wu, Yuanjie Zhang, Wen Shi, Zhiqian Chen, Xindang Chu, Jiayu Hu, Liwen Hua, Yiming Wang, Yanning Zhu, Yu Mu, Hanwen Sun, Chuanling Zhang, Qi Wang, Sulong Xiao, Lihe Zhang, Bo Zhang, Demin Zhou   +23 more
wiley   +1 more source

Preparative‐Scale Biocatalytic Oxygenation of N‐Heterocycles with a Lyophilized Peroxygenase Catalyst

Angewandte Chemie, Volume 135, Issue 5, January 26, 2023., 2023
A lyophilized preparation of an unspecific peroxygenase variant from Agrocybe aegerita (rAaeUPO‐PaDa‐I‐H) is a highly effective catalyst for the oxygenation of a diverse range of N‐heterocyclic compounds. Scalable, high yielding and enantioselective biocatalytic oxygenations have been developed, including 27 preparative examples (ca.
Balázs Pogrányi, Tamara Mielke, Alba Díaz‐Rodríguez, Jared Cartwright, William P. Unsworth, Gideon Grogan   +5 more
wiley   +1 more source

Structure of the Saccharolobus solfataricus GINS tetramer. [PDF]

Acta Crystallogr F Struct Biol Commun
Shankar S, Enemark EJ.
europepmc   +1 more source

Arabidopsis is susceptible to infection by a downy mildew fungus.

The Plant Cell, 1990
E. Koch, A. Slusarenko
semanticscholar   +1 more source

Human Cloning: Religious and Ethical Issues [PDF]

, 2011
Shannon, Thomas A.
core   +2 more sources

Hierarchical Regulatory Networks Reveal Conserved Drivers of Plant Drought Response at the Cell‐Type Level

Advanced Science, EarlyView.
This study presents a comprehensive multi‐omics framework to uncover cell‐type‐specific regulatory networks in plant drought responses. By integrating transcriptomic, proteomic, and epigenetic data from nearly 30 000 samples, key regulators such as CIPK23 and NLP7 are identified, revealing insights into conserved drought tolerance mechanisms and ...
Moyang Liu, Yuanyuan Xu, Yue Song, Dongying Fan, Junpeng Li, Zhen Zhang, Lujia Wang, Juan He, Cheng Chen, Chao Ma   +9 more
wiley   +1 more source