Results 181 to 190 of about 84,775 (197)

Engineered proxies and the illusion of de-extinction. [PDF]

Stem Cell Reports
Ilic D.
europepmc   +1 more source

Metabolic Flux Analysis Reveals Cell Line‐Specific Rewiring in CHO Cells Following TCA Cycle Intermediate Feeding for Bioprocess pH Control

Biotechnology and Bioengineering, EarlyView.
ABSTRACT Chinese hamster ovary (CHO) cells are the leading host for recombinant therapeutic protein production in the biopharma industry. In this study, we investigated how feeding acidic forms of tricarboxylic acid (TCA) cycle intermediates—malic acid, succinic acid, and α‐ketoglutaric acid—affects cell culture performance and metabolism in two ...
Sarah A. Sacco, Kevin J. Ruiz‐Márquez, Rachel Moen, Irina Trenary, Xiaolin Zhang, Xiaowen Wang, Malik Padellan, Henry Lin, Jamey D. Young   +8 more
wiley   +1 more source

Rhizobium radiobacter bloodstream infection associated with long-term central venous access in an infant with Pompe disease. [PDF]

Infez Med
Cuccia A, Albano C, Garbo V, Venuti L, Boncori G, Linares G, Saporito L, Falletta F, Colomba C.   +8 more
europepmc   +1 more source

Discovery of CRBN‐based molecular glue degraders targeting WIZ transcription factor

Bulletin of the Korean Chemical Society, EarlyView.
This work reports the discovery of 9l, a novel cereblon‐based molecular glue degrader which targets the WIZ transcription factor. Compound 9l facilitates WIZ‐CRBN ternary complex formation to degrade WIZ, subsequently inducing γ‐globin expression in HUDEP‐2 cells and highlighting its potential as a sickle cell disease therapy.
Tae‐Jun Kim, Seongu Seong, Jung‐Ae Kim, Taeyeon Kwon, Hyun Jin Kim, Jeong‐Hoon Kim, Jong Yeon Hwang, Jin Hwa Cho, Kyoungmin Choi   +8 more
wiley   +1 more source

Multiphase terminal environmental disinfection targeting Acinetobacter baumannii sustains reduction in multidrug-resistant organism healthcare-associated infections in an ICU. [PDF]

Antimicrob Resist Infect Control
Qiu S, Xu Q, Mao Y, Gong Y, Huang Q, Wang H, Chen M, Ni F, Xu H, Wang J.   +9 more
europepmc   +1 more source

Nanomaterial‐based immune therapeutic strategies in neurodegenerative diseases

BMEMat, EarlyView.
This review highlights the immunomodulatory potential of nanomaterials (NMs) in treating neurodegenerative diseases (NDs). It focuses on their roles in regulating innate and adaptive immune responses to maintain immune homeostasis. By providing insights into these mechanisms, the review lays the groundwork for innovative NMs therapeutic strategies to ...
Xinru Zhou, Jia Liu, Shulin Lai, Suhan Yin, Bingmin Luo, Longquan Shao, Yiyuan Kang   +6 more
wiley   +1 more source

Aerobic Microbiological Profile and Antimicrobial Resistance Trends in Sterile Body Fluid Infections Over Nine Years: A Retrospective Analysis from a Tertiary-Care Center. [PDF]

Infect Drug Resist
Alharbi NA, Alshafie HA, Haddad M, Muhajir AA, Alqahtani AJ, Shabi Y, Altalhi MO, Bahkali MH, Alsaeed TS, Alshehri AA, Alqahtani MA, Elgujja A, Alshahrani FS.   +12 more
europepmc   +1 more source

Carrier‐free self‐assembled nanomedicine for combination‐therapy of acute myeloid leukemia

BMEMat, EarlyView.
CPDS combines drugs with three different mechanisms of action to achieve a multi‐mechanism combination therapy for AML by directly killing tumor cells and activating anti‐tumor immunity. Abstract As the main acute myeloid leukemia (AML) clinical treatment, the chemotherapy alone cannot meet the clinical therapeutic needs due to the high heterogeneity ...
Meihong Chai, Rui Zhang, Haiyin Yang, Jiyue Xing, Tianyuan Hu, Mengxi Zhu, Rui Li, Xiaoli Chen, Beibei Zhao, Yang Lan, Stefan Barth, Yuanyu Huang, Li Zhang, Mengjie Zhang, Huining He   +14 more
wiley   +1 more source

Enhanced saccharification yields from rice straw by senescence-induced expression of a cytokinin biosynthesis gene in intragenic rice plants. [PDF]

Plant Biotechnol (Tokyo)
Miura K, Nishimura H, Ito Y.
europepmc   +1 more source

Considerations for Domestication of Novel Strains of Filamentous Fungi. [PDF]

ACS Synth Biol
Pullen RM, Decker SR, Subramanian V, Adler MJ, Tobias AV, Perisin M, Sund CJ, Servinsky MD, Kozlowski MT.   +8 more
europepmc   +1 more source