A Catalytic Osmium Redox Couple Collapses Cancer Redox Balance
Advanced Science, EarlyView.A stable Os(III)/Os(IV) redox couple is developed to disrupt the tumor cell redox balance by concurrently catalyzing ROS generation and GSH depletion. Osmium‐treated cells exhibit multiple cell death pathways, including apoptosis, ferroptosis, and immunogenic cell death.
Wan‐Qiong Huang +9 more
wiley +1 more source
Rapid Identification of Superior Endogenous Signal Peptides for Heterologous Protein Secretion by Corynebacterium glutamicum Through Modular Cloning and Automation. [PDF]
Microb BiotechnolMatamouros S +4 more
europepmc +1 more source
Advanced Science, EarlyView.Palatable food alleviates stress and prevents anxiety. This study uncovers a dedicated neural pathway: dopamine release in the PFC activates D1R neurons, whose projections to the peri‐PVN engage a population of anxiolytic CRFR1 neurons. These neurons then inhibit stress‐induced hyperactivity of PVNCRF neurons, providing a circuit‐level explanation for ...
Yuchuan Hong +12 more
wiley +1 more source
Advances in gene cloning and functional genomics approaches for wheat (Triticum aestivum L.) improvement. [PDF]
Plant GenomeGudi S +6 more
europepmc +1 more source
[Cloning and the ethical problems it poses]
, 1999 The birth of a cloned ewe in a Scottish laboratory in 1997 has brought the question of human cloning to the forefront. Having become technically likely, its possibility called for rigorous ethical discernment: with a certain unanimity, national and ...
Bone, E.
core
Stage‐Specific H3K14 and H3K23 Succinylation Orchestrates Insect Metamorphosis and Oogenesis
Advanced Science, EarlyView.Stage‐specific succinylation of histone H3 at lysine 14 and 23 differentially controls insect metamorphosis and oogenesis through distinct GPCR‐PKC signaling cascades, revealing an evolutionarily conserved epigenetic mechanism that coordinates key life‐history traits.
Yu‐Pu Jing +9 more
wiley +1 more source
Knockdown of <i>armc3</i> Impairs Motile Cilia Function in <i>Schmidtea mediterranea</i>. [PDF]
MicroPubl BiolGogoi C +4 more
europepmc +1 more source
Trophic Diversity in Duckweed: Mixotrophy, More Than the Sum of its Extremes
Advanced Science, EarlyView.In the context of rising DOC in aquatic environments, mixotrophic duckweed may impact carbon cycling by acting as either a carbon sink, as they absorb CO2 through photosynthesis, or a carbon source, as they release CO2 through respiration of absorbed DOC, which depends on DOC concentration, light availability, temperature, and other environmental ...
Zuoliang Sun +5 more
wiley +1 more source
NLSS3 Impairs SHM1 Autophagic Degradation to Regulate Leaf Morphology and Salt Tolerance in Rice
Advanced Science, EarlyView.In rice, NLSS3 binds and shields SHM1 from autophagic degradation to maintain serine homeostasis. The A132P mutation in nlss3 disrupts this, triggering SHM1 loss, metabolic dysfunction, K+ imbalance, and impaired ROS scavenging, which collectively drive narrow leaves and salt sensitivity.
Xiong Liu +15 more
wiley +1 more source
CloneFast: A simple plasmid design and construction guide for labs venturing into synthetic biology. [PDF]
STAR ProtocFung V, Tiwade PB, Fenton OS.
europepmc +1 more source