Results 211 to 220 of about 169,769 (295)

Efficient Somatic Cell Nuclear Transfer by Overcoming Both Pre‐ and Post‐Implantation Epigenetic Barriers

Advanced Science, EarlyView.
Mammalian cloning via SCNT is limited by several epigenetic barriers. Kdm4d/Kdm5b overexpression plus TSA treatment overcomes epigenetic barriers during pre‐implantation development, while tetraploid complementation replaces defective extraembryonic lineages to bypass H3K27me3 imprinting loss to overcome epigenetic barriers in post‐implantation ...
Yamei Li, Shiyu Sun, Yuting Xu, Jixiang Zhang, Yi Du, Yaxin Cao, Zhaodi Liao, Yali Xie, Xinyan Bian, Jiantao Huang, Meijiao Wang, Zhen Liu, Qiang Sun, Falong Lu   +13 more
wiley   +1 more source

Birth of India's first cloned cattle and analysis of its health and reproduction status: A case study. [PDF]

Sci Rep
Selokar NL, Singh MK, Tripathi G, Patel K, Verma R, Singh P, Aswal A, Chauhan MS.   +7 more
europepmc   +1 more source

Gut Parabacteroides distasonis‐derived Indole‐3‐Acetic Acid Promotes Phospholipid Remodeling and Enhances Ferroptosis Sensitivity via the AhR‐FASN Axis in Bladder Cancer

Advanced Science, EarlyView.
Indole‐3‐acetic acid (3‐IAA) derived from gut P. distasonis binds to AhR in bladder cancer cells and downregulates FASN transcription, thereby increasing sensitivity to ferroptosis and suppressing the development of bladder tumors. Specifically, 3‐IAA treatment leads to an increase in the proportion of PC/PE‐PUFAs and a decrease in the proportions of ...
Weijia Li, Wentai Shangguan, Wenxue Huang, Jie Zhao, Yuexuan Zhu, Ming Xie, Yao Yu, Qishen Yang, Jun Zheng, Lin Yang, Qi Sun, Leqian Li, Xinhang Shi, Yongyuan Xiao, Hai Huang, Bisheng Cheng, Peng Wu   +16 more
wiley   +1 more source

Development of the First Shuttle Vector System and Optimization of Transformation in <i>Selenomonas sputigena</i>. [PDF]

J Microbiol Biotechnol
Nguyen TT, Kim YK, Ko D, Kim J, Yi H, Bang YJ.   +5 more
europepmc   +1 more source

Single‐Cell Transcriptome Profiling Reveals Conserved IFNγ‐IL8 Signaling‐Induced Antibacterial Neutrophil States during Bacterial Infection

Advanced Science, EarlyView.
SummaryThis study constructs a single‐cell immune atlas of Nile tilapia across multiple time points during Streptococcus agalactiae infection, revealing dynamic immune cell responses and subtype transitions. It identifies a conserved IFNr‐STAT1‐IL8 axis driving il8+ neutrophils activation and antibacterial function, supported by cross‐species ...
Xue Zhai, Minghao Zhang, Kang Li, Wei Li, Xiaolong Li, Wa Gao, Zhaosheng Sun, Dan Huang, Songqian Huang, Mingli Liu, Zhichao Wu, Jun Zou, Liangbiao Chen, Jialong Yang, Peng Hu   +14 more
wiley   +1 more source

Reply to Nachamkin, "Diversity of <i>Campylobacter</i> species in a rhesus macaque breeding colony". [PDF]

mSphere
Bacon RL, Hodo CL, Lawhon SD.
europepmc   +1 more source

KRAS mRNA Spleen‐Targeting Lipid Nanoparticles Synergize with Irinotecan Silicasomes to Robustly Augment the Cancer Immunity Cycle in Pancreatic Cancer

Advanced Science, EarlyView.
To overcome pancreatic cancer's immunosuppressive barriers, this study explores a dual approach: triggering immunogenic tumor cell death at the primary tumor site with irinotecan‐loaded silicasomes and enhancing immune activation in the spleen using LNPs encapsulating tumor antigen mRNA and a TLR7/8 agonist.
Lijia Luo, Xiang Wang, Yu‐Pei Liao, Andre E. Nel   +3 more
wiley   +1 more source

The Drosophila DEG/ENaC PPK12 is a Na⁺ leak channel with a low Na⁺ affinity. [PDF]

Sci Rep
Qin L, Komarov N, Fritsch C, Sprecher SG, Gründer S, Wiemuth D.   +5 more
europepmc   +1 more source

When Did I Begin? Another Critical Response to Norman Ford [PDF]

, 1991
Flaman, Paul
core   +1 more source

Viral‐Directed Augmentation of Kupffer Cell Cross‐Presentation Provokes Antitumor Immunity Against Liver Metastasis

Advanced Science, EarlyView.
Targeting Kupffer cells (KC) with a single intravenous infusion of the oncolytic virus VSV‐M51R rather than VSV‐WT induces effective tumor regression in various types of liver metastatic cancers in mice. VSV‐M51R promotes KC proliferation and enhances their antigen cross‐presentation capacity without compromising viability, leading to the induction of ...
Chen Chen, Qing Zhang, Jiajia Li, Xia Zhou, Daxing Gao, Lu Li, Dabing Huang, Jizhou Wang, Zhutian Zeng   +8 more
wiley   +1 more source