Results 291 to 300 of about 1,771,671 (365)

Detecting the Difficult: An Intronic NPC1 Variant Hiding in Plain Sight

American Journal of Medical Genetics Part A, EarlyView.
ABSTRACT An illustration of the importance of manual data review for identifying rare intronic variants adjacent to homopolymers is presented here. A 14‐year‐old male with Niemann‐Pick Type C disease confirmed biochemically was only found to have a heterozygous pathogenic variant by molecular analysis. A manual review of the Next Generation Sequencing (
Caroline Gully Brown, Matthew Bower, Matthew Schomaker, Jessica Goldstein, Jeanine Jarnes, Chester B. Whitley, Nishitha R. Pillai   +6 more
wiley   +1 more source

Development of a TaqMan qPCR for the Simultaneous Detection of the TuMV and BBWV2 Viruses Responsible for the Viral Disease in Pseudostellaria heterophylla. [PDF]

Microorganisms
Gu L, Liu C, Yao S, Wu J, Wang L, Mu J, Wang Y, Wang J, Zhang Z, Li M.   +9 more
europepmc   +1 more source

The Extremophiles: Adaptation Mechanisms and Biotechnological Applications. [PDF]

Biology (Basel)
Marzban G, Tesei D.
europepmc   +1 more source

Regulation of Human Cloning: Implication for Biotechnological Advancement [PDF]

, 2011
McDaniel, Michael J.
core   +2 more sources

Human TDP43 is required for ALS‑related annexin A11 toxicity in Drosophila. [PDF]

Biomed Rep
Barnard J, Hunt R, Yucel M, Mazaud D, Smith BN, Fanto M.   +5 more
europepmc   +1 more source

Gromomycins: An Unprecedented Class of Triterpene Antibiotics Produced by a Novel Biosynthetic Pathway

Angewandte Chemie, EarlyView.
Gromomycins represent a novel class of pentacyclic triterpene antibiotics with a unique biosynthetic pathway independent of the squalene route. These compounds exhibit potent activity against drug‐resistant Gram‐positive pathogens, including MRSA, and their unprecedented cyclization mechanism provides new insight into bacterial triterpene biosynthesis.
Stepan Tistechok, Dmytro Bratiichuk, Hilda Sucipto, Nils Gummerlich, Marc Stierhof, Oleksandr Gromyko, Franziska Fries, Victor Fedorenko, Rolf Müller, Josef Zapp, Maksym Myronovskyi, Andriy Luzhetskyy   +11 more
wiley   +1 more source

How advancements in molecular biology impact education and training. [PDF]

J Microbiol Biol Educ
Walther RE, Hrabak M, Bernstein DA.
europepmc   +1 more source

Evolution‐Guided Discovery of Antimycobacterial Triculamin‐Like Lasso Peptides

Angewandte Chemie, EarlyView.
The hypothesized convergent biosynthesis of triculamin‐like lasso peptides from different biosynthetic gene cluster (BGC) types represented across multiple bacterial phyla. The elucidation of the triculamin non‐canonical BGC and resistance mechanism by heterologous expression in Streptomyces albus and in vitro acetylation with resistance conveying ...
Aske Merrild, Tiziana Svenningsen, Marc G. Chevrette, Thomas Tørring   +3 more
wiley   +1 more source

Correction: Suleman et al. Immunoinformatics and Immunogenetics-Based Design of Immunogenic Peptides Vaccine against the Emerging Tick-Borne Encephalitis Virus (TBEV) and Its Validation through In Silico Cloning and Immune Simulation. Vaccines 2021, 9, 1210. [PDF]

Vaccines (Basel)
Suleman M, Tahir Ul Qamar M, Kiran, Rasool S, Rasool A, Albutti A, Alsowayeh N, Alwashmi ASS, Aljasir MA, Ahmad S, Hussain Z, Rizwan M, Ali SS, Khan A, Wei DQ.   +14 more
europepmc   +1 more source

Saarvienin A—A Novel Glycopeptide with Potent Activity against Drug‐Resistant Bacteria

Angewandte Chemie, EarlyView.
A structurally distinct glycopeptide, saarvienin A, represents a new family of glycopeptide antibiotics consisting of five sugar/aminosugar units connected to a halogenated peptide core. Saarvienin A overcomes vancomycin resistance and shows strong activity against drug‐resistant Gram‐positive bacteria, in particular, high‐priority pathogens such as ...
Amninder Kaur, Jaime Felipe Guerrero‐Garzón, Sari Rasheed, Martin Zehl, Franziska Fries, Bernd Morgenstern, Sergey B. Zotchev, Rolf Müller   +7 more
wiley   +1 more source