Results 171 to 180 of about 687,759 (305)

Identification of (20R)‐protopanaxadiol from Panax ginseng as a novel anti‐SARS‐CoV‐2 compound

FEBS Open Bio, EarlyView.
We established a noninfectious BAC‐based SARS‐CoV‐2 replicon that enables antiviral screening under BSL‐2 conditions. Using this platform, we screened 373 food‐derived compounds and identified (20R)‐protopanaxadiol from Panax ginseng as a novel inhibitor of SARS‐CoV‐2 RNA replication, highlighting the value of safe replicon systems for antiviral ...
Midori Takeda, Natsue Maezono, Rina Uchikoshi, Nobuyuki Kato, Masanori Ikeda   +4 more
wiley   +1 more source

Therapeutic cloning: from consequences to contradiction

, 2002
The British Parliament legalized therapeutic cloning in December 2000 despite opposition from the European Union. The watershed event in Parliament's move was the active and unprecedented government support for the generation and destruction of human ...
Coors, Marilyn E.
core  

Evolution‐guided yeast complementation reveals functional differences in human PSPH variants

FEBS Open Bio, EarlyView.
Ancient genomes can help guide which human genetic variants are tested experimentally. This study applies that idea to PSPH, a gene involved in serine biosynthesis, and uses high‐throughput yeast complementation to compare variant function. The findings reveal measurable differences among selected alleles and illustrate the value of evolution‐guided ...
Mauricio Campa‐Álvarez, Diana Ascencio, Miguel Vallebueno‐Estrada, Eduardo González‐Orozco, Christian Eduardo Martínez‐Guerrero, Rafael Montiel, Alexander DeLuna   +6 more
wiley   +1 more source

HUMAN CLONING IN THE MEDIA: FROM SCIENCE FICTION TO SCIENCE PRACTICE

, 2008
List of figures -- Acknowledgements -- 1. Introduction -- 2. What is cloning? -- 3. Cloning futures -- 4. Mavericks, madmen and fallen heroes -- 5. Women's bodies in cloning discourse -- 6. Truth claims and genres -- 7.
Haran, Joan; Kitzinger, Jenny; McNeil, Maureen; and O'Riordan, Kate
core  

PrimerWeaver: an integrated web server for primer design in molecular biology workflows. [PDF]

Nucleic Acids Res
Jin Z, Kim Y, Ignea C.
europepmc   +1 more source

Identifying and characterising a plant GH1 β‐glucosidase that exhibits hydrolytic activity on N‐linked glucopyranoside

FEBS Open Bio, EarlyView.
We report the first β‐glucosidase with demonstrated hydrolytic activity on an N‐linked glycopyranoside. The enzyme, native to maize, was biochemically characterised for this novel reaction, and structural modelling of the enzyme–substrate complex revealed several clues to the underlying reduced catalytic rate relative to its native O‐glycopyranoside ...
Hani Gharabli, Carlotta Chiesa, Maher Abou Hachem, Ditte Hededam Welner   +3 more
wiley   +1 more source

I AM THE OTHER: LITERARY NEGOTIATIONS OF HUMAN CLONING

, 2005
Acknowledgments -- Introduction -- Ch. 1. "The hell of the same": from Plato to Baudrillard -- Ch. 2. "This sex which is one": writing men out in selected science fiction texts -- Ch. 3. The Zeus syndrome: womb envy and male pregnancy -- Ch. 4.
Seabra Ferreira, Maria Aline Salgueiro
core  

Molecular cloning of a monkeypox virus clade IIb genome and construction of an attenuated mutant for basic and translational research. [PDF]

Emerg Microbes Infect
Klatt V, Meyer Zu Natrup C, Staliunaite L, Clever S, Knickmann J, Ohrnberger S, Seib J, Ostermann E, Weichel HM, Addo MM, Volz A, Brune W.   +11 more
europepmc   +1 more source

Structural studies and functional engineering of NanX: an anhydro‐sialic acid transporter from Escherichia coli

FEBS Open Bio, EarlyView.
Biophysical characterisation shows that NanX, a membrane transport protein from the major facilitator superfamily (MFS), forms both monomers and dimers after purification. AlphaFold modelling and substrate docking provide information on residues likely involved in substrate recognition for NanX and another MFS member, NanT.
Michael C. Newton‐Vesty, Kelsi R. Hall, Zachary D. Tillett, Liam S. Turk, James S. Davies, Michael J. Currie, Hamish G. Brown, Sepideh Valimehr, Peter D. Mace, Andrew E. Whitten, Santosh Panjikar, Eric Hanssen, Rachel A. North, Renwick C.J. Dobson   +13 more
wiley   +1 more source

A Bill to Prohibit the Cloning of Humans

, 2001
Human Cloning Prohibition Act S ...
United States. Congress. Senate
core