Results 61 to 70 of about 169,996 (318)

Trends in drug–drug interaction prevalence and longitudinal associations with health outcomes in the older community‐dwelling population: Findings from The Irish LongituDinal study on Ageing

British Journal of Clinical Pharmacology, EarlyView.
Aims We estimate trends in severe drug–drug interaction (DDI) prevalence and examine longitudinal associations between DDI exposure and health outcomes (emergency department [ED] visits, quality‐of‐life [QoL] and functional decline) over approximately 10‐years in the older community‐dwelling population in Ireland.
John E. Hughes, Caitriona Cahir, Kathleen E. Bennett   +2 more
wiley   +1 more source

Intravascular Ultrasound Findings Associated With Hydrodynamic Contrast Recanalization (HDR) of Coronary Chronic Total Occlusions

Catheterization and Cardiovascular Interventions, EarlyView.
ABSTRACT Background Hydrodynamic contrast recanalization (HDR) is a novel technique to facilitate wire crossing during chronic total occlusion (CTO) percutaneous coronary interventions (PCI). The mechanisms underlying HDR have not been fully described.
Salman A. Arain, Angelo Nascimbene, Akshitha Yarrabothula, Jaime Hudson, Emmanouil S. Brilakis, Antonio Colombo, Lorenzo Azzalini, M. Bilal Iqbal, Bernardo Cortese, Yukata Tadano, Tsutomu Fujita, Mauro Carlino, Biswajit Kar   +12 more
wiley   +1 more source

Comparison of Fixed‐Dose Clopidogrel/Asetylsalicylic Acid Combination and Standard Loading Strategy During Percutaneous Coronary Intervention in Chronic Coronary Syndrome

Catheterization and Cardiovascular Interventions, EarlyView.
ABSTRACT Background Dual antiplatelet therapy (DAPT), comprising acetylsalicylic acid and a P2Y12 receptor inhibitor such as clopidogrel, is the cornerstone of management in patients undergoing percutaneous coronary intervention (PCI). While conventional loading doses of acetylsalicylic acid and clopidogrel are well established, there is limited ...
Ahmet Anıl Başkurt, Oktay Şenöz, Yusuf Demir, Eren Ozan Bakır, Ferhat Siyamend Yurdam, Ecem Gürses, İlhan Koyuncu, Ahmet Erseçgin, Saadet Aydın, Zeynep Yapan Emren, İlker Gül   +10 more
wiley   +1 more source

Abrupt Cessation of One-Year Clopidogrel Treatment Is Not Associated With Thrombotic Events

Journal of Pharmacological Sciences, 2011
.: We aimed to examine the rate of thrombotic events after discontinuation of one year clopidogrel therapy in patients with implanted coronary stent, and to determine platelet aggregability by multiple electrode analyzer after cessation of clopidogrel ...
Nina Djukanovic, Zoran Todorovic, Slobodan Obradovic, Danijela Zamaklar-Trifunovic, Srdjana Njegomirovic, Nataša M. Milic, Milica Prostran, Miodrag Ostojic   +7 more
doaj   +1 more source

P2Y12 Inhibitors in Acute Coronary Syndromes: A Real-World, Community-Based Comparison of Ischemic and Bleeding Outcomes

Journal of Interventional Cardiology, 2023
Background. Randomized trials have shown superiority of the novel P2Y12 inhibitors over clopidogrel in patients with acute coronary syndrome (ACS), but clinical benefit in the community remains controversial.
Amit Sachdeva, Ratnabhushan Mutyala, Neha Mantri, Shiyun Zhu, Edward McNulty, Matthew Solomon   +5 more
doaj   +1 more source

Clinically Significant Bleeding With Ticagrelor Versus Clopidogrel in Korean Patients With Acute Coronary Syndromes Intended for Invasive Management: A Randomized Clinical Trial.

Circulation, 2019
Owing to the differential propensity for bleeding and ischemic events with response to antiplatelet therapy, the safety and effectiveness of potent P2Y12 inhibitor ticagrelor in East Asian populations remain uncertain.
Duk‐Woo Park, O. Kwon, Jae-Sik Jang, S. Yun, Hanbit Park, Do-Yoon Kang, Jung‐Min Ahn, P. Lee, Seung‐Whan Lee, Seong-Wook Park, Si-Wan Choi, Sang‐Gon Lee, H. Yoon, T. Ahn, Moo-Hyun Kim, D. Nah, S. Lee, J. Chae, Seung‐Jung Park   +18 more
semanticscholar   +1 more source

Coronary Ectasia and ST Elevation Myocardial Infarction Patients: Does Atherosclerosis Influence Periprocedural Management and Long‐Term Prognosis?

Catheterization and Cardiovascular Interventions, EarlyView.
ABSTRACT Background Coronary artery ectasia (CAE) influences procedural outcomes in the context of ST‐elevation myocardial infarction (STEMI); however, its relationship with atherosclerotic coronary artery disease (ACAD) remains unclear. Aims This study aimed to compare clinical and procedural characteristics, as well as outcomes, in patients with ...
Victorine Fraichot, Jeanne Varlot, Florian Eggenspieler, Nassima Djaballah, Pierre Adrien Metzdorf, Edoardo Camenzind, Batric Popovic   +6 more
wiley   +1 more source

Effects of cytochrome P450 2C19 and paraoxonase 1 polymorphisms on antiplatelet response to clopidogrel therapy in patients with coronary artery disease. [PDF]

PLoS ONE, 2014
Clopidogrel is an antiplatelet prodrug that is recommended to reduce the risk of recurrent thrombosis in coronary artery disease (CAD) patients. Paraoxonase 1 (PON1) is suggested to be a rate-limiting enzyme in the conversion of 2-oxo-clopidogrel to ...
Damrus Tresukosol, Bhoom Suktitipat, Saowalak Hunnangkul, Ruttakarn Kamkaew, Saiphon Poldee, Boonrat Tassaneetrithep, Atip Likidlilid   +6 more
doaj   +1 more source

Aortic Dissection With Pseudoaneurysm Formation Masquerading as Pulmonary Embolism After Transcatheter Aortic Valve Replacement

Catheterization and Cardiovascular Interventions, EarlyView.
ABSTRACT Transcatheter aortic valve replacement (TAVR) is a commonly performed procedure for the treatment of severe aortic stenosis. While it is generally considered a low‐risk procedure, one of the rare potentially life‐threatening complications includes aortic dissection.
Heather Wang, Juan Bello, Dhir Gala, Jeffrey S. Lander   +3 more
wiley   +1 more source

Clopidogrel, a P2Y12 receptor antagonist, potentiates the inflammatory response in a rat model of peptidoglycan polysaccharide-induced arthritis.

PLoS ONE, 2011
The P2Y12 receptor plays a crucial role in the regulation of platelet activation by several agonists, which is irreversibly antagonized by the active metabolite of clopidogrel, a widely used anti-thrombotic drug.
Analia E Garcia, Sripal R Mada, Mario C Rico, Raul A Dela Cadena, Satya P Kunapuli   +4 more
doaj   +1 more source