Results 41 to 50 of about 971 (151)

Resistência ao clopidogrel: prevalência e variáveis associadas Resistance to clopidogrel: prevalence and associate variables

Arquivos Brasileiros de Cardiologia, 2012
FUNDAMENTO: A dupla terapia antiagregante plaquetária com ácido acetilsalicílico e clopidogrel é pedra angular do tratamento de pacientes submetidos a angioplastia com implante de stents coronarianos. Todavia, parte desses pacientes, a despeito do uso de
Fabrício Braga da Silva, Gustavo Luiz Gouvêa de Almeida Junior, Augusto Neno, José Kezen, Milena Spelta, Alessandra Godomiczer, Renato Villela, Bruno Hellmuth, Sergio Salles Xavier, Roberto Hugo da Costa Lins   +9 more
doaj   +3 more sources

Remote platelet function testing using P-selectin expression in patients with recent cerebral ischaemia on clopidogrel

Stroke and Vascular Neurology
Background Antiplatelet agents reduce recurrence after cerebral ischaemia but are not effective in all patients, in part because of treatment resistance. The primary aim was to assess the proportion of patients who are insensitive to clopidogrel.
Philip M Bath, Nikola Sprigg, Jason Philip Appleton, Carla Richardson, Natalia Dovlatova, Jane May, Stan Heptinstall   +6 more
doaj   +1 more source

Clopidogrel Resistance: Myth or Reality?

Journal of Cardiovascular Pharmacology and Therapeutics, 2006
Platelets have a central role in the development of arterial thrombosis and subsequent cardiovascular events. An appreciation of this complex process has made antiplatelet therapy the cornerstone of cardiovascular disease management. Dual antiplatelet therapy with aspirin and clopidogrel has been approved for the secondary prevention of cardiovascular
Aron A. Barsky, Rohit Arora
openaire   +3 more sources

Low-Dose Prasugrel in Patients with Resistance to Clopidogrel for the Treatment of Cerebral Aneurysms [PDF]

Neurointervention, 2018
Thromboembolism is one of the major complications of stent assisted coiling in treatment of cerebral aneurysm. Clopidogrel resistance is so common and prasugrel is more effective in its rapid and potent effect.
Dongwhane Lee, Yunsun Song, Minkyu Han, Danbi Park, Dae Chul Suh   +4 more
doaj   +1 more source

Aspirin and clopidogrel resistance in Indian patients with ischemic stroke and its associations with gene polymorphisms: A pilot study

Annals of Indian Academy of Neurology, 2019
Introduction: Antiplatelet resistance is one of the urgent issues in current stroke care. One-third to one-half of the patients who experience a recurrent stroke is already on antiplatelet medications.
Samir Patel, Vandana Arya, Amrita Saraf, Manorama Bhargava, C S Agrawal   +4 more
doaj   +1 more source

Clopidogrel Resistance in Stroke Cases

Istanbul Medical Journal, 2019
Introduction:Clopidogrel treatment is one of the standard treatments in terms of reducing mortality and morbidity in patients with cerebrovascular disease diagnosed with large artery atherosclerosis. However, resistance to clopidogrel treatment is a significant problem today. In this study, we aimed to retrospectively investigate clopidogrel resistance
Nihan Çarçak, Büşra Tuğba Özmen, Zeynep Selcen Dartıcı, Ufuk Emre, Özgür Kılıçkesmez   +4 more
openaire   +3 more sources

Prevalence of CYP2C19*2 and CYP2C19*3 Allelic Variants and Clopidogrel Use in Patients with Cardiovascular Disease in Trinidad & Tobago

Cardiology and Therapy
Introduction Trinidad & Tobago has the highest prevalence of cardiovascular disease (CVD) in the Caribbean and clopidogrel is a ubiquitously used treatment. Yet, the extent of genetically mediated clopidogrel resistance is unknown.
Daniele Jones, Shana Persad-Ramdeensingh, Sheherazade Crystal Abrahim, Naveen Seecheran, Rajini Rani Haraksingh   +4 more
doaj   +1 more source

ACC/AHA CLOPIDOGREL CLINICAL ALERT. WHAT MUST BE MODERN ANTIPLATELET THERAPY?

Рациональная фармакотерапия в кардиологии, 2016
The ACC/AHA clopidogrel clinical alert about the possibility of ineffective treatment with clopidogrel is discussed. The reason of this resistance to clopidogrel therapy and possible ways to overcome it is considered.
S. J. Martsevich
doaj   +1 more source

Clopidogrel resistance and its relevance: Current concepts

Journal of Family Medicine and Primary Care
Clopidogrel is the most widely used P2Y12 receptor inhibitor (P2Y12i) as a part of dual antiplatelet therapy along with aspirin. Clopidogrel is a pro-drug and is metabolized to its active metabolite by the hepatic enzyme cytochrome P4502C19 (CYP2C19 ...
Akshyaya Pradhan, Monika Bhandari, Pravesh Vishwakarma, Rishi Sethi   +3 more
doaj   +1 more source

Antiplatelet drug resistance in patients with coronary heart disease

Кардиоваскулярная терапия и профилактика, 2012
Coronary angioplasty is an important component of coronary heart disease (CHD) management. There is a substantial evidence of the need for dual antiaggregant therapy (clopidogrel and aspirin) in this clinical group, both before and after the intervention.
V. A. Sulimov, E. V. Moroz
doaj   +1 more source