Results 71 to 80 of about 2,233,111 (188)

Pharmacogenomics in Dentistry: From CYP‐Mediated Drug Response to Precision Prescribing in Oral Healthcare

Oral Diseases, EarlyView.
ABSTRACT Objective This narrative review critically assesses the clinical relevance of pharmacogenomics within dental genomics, distinguishing clinically actionable applications from emerging or investigational findings. Materials and Methods A targeted literature review was conducted in PubMed/MEDLINE, Scopus and Embase for publications from January ...
Giorgia Pieretto, Jessica Cusato, Martina Sansavini, Christian Bacci   +3 more
wiley   +1 more source

Can We Override Clopidogrel Resistance? [PDF]

Circulation, 2009
Clopidogrel, a thienopyridine antiplatelet agent, has been used alone or in association with aspirin to prevent vascular complications in atherothrombotic patients. It is also, in combination with aspirin, the key treatment to prevent stent thrombosis in patients who have undergone percutaneous coronary intervention.
Ana, Pena, Jean-Philippe, Collet, Jean-Sébastien, Hulot, Johanne, Silvain, Olivier, Barthélémy, Farzin, Beygui, Christian, Funck-Brentano, Gilles, Montalescot   +7 more
openaire   +2 more sources

ACC/AHA CLOPIDOGREL CLINICAL ALERT. WHAT MUST BE MODERN ANTIPLATELET THERAPY?

Рациональная фармакотерапия в кардиологии, 2016
The ACC/AHA clopidogrel clinical alert about the possibility of ineffective treatment with clopidogrel is discussed. The reason of this resistance to clopidogrel therapy and possible ways to overcome it is considered.
S. J. Martsevich
doaj   +1 more source

The effect of doubling the dose of clopidogrel on platelet aggregation in patients with clopidogrel resistance [PDF]

, 2014
Antiplatelet drugs play a pivotal role in the management of patients with acute coronary syndrome. Clopidogrel is an important antiplatelet drug commonly used in the treatment of those patients. However, the variability in patient response to clopidogrel
George S. Mina, Habib, Bassem W., John I. Louca, Sadek, Sameh E., Bassem W. Habib, Sameh E. Sadek, Mina, George S., Louca, John I.   +7 more
core   +1 more source

Carotid artery dissection linked to intermittent apnoeic swimming: A case–control study

Experimental Physiology, EarlyView.
Abstract Internal carotid artery (ICA) dissection is a rare and potentially devastating cause of cerebral ischaemia, initiated by an intimal tear or rupture of the vasa vasorum, that can lead to an intraluminal thrombus, vascular stenosis, occlusion, or dissecting aneurysm formation.
Damian M. Bailey, Richard G. Davies, Brenig L. Gwilym, Benjamin S. Stacey, Danny Walmsley, Michael H. Lewis, Josip Butkovic, Ivan Mumlek, Brad Perry, Zvonomir Vrselja, Shigehiko Ogoh, James A. Pawelczyk, Mohamad Bashir, Richard D. White, Ian M. Williams   +14 more
wiley   +1 more source

A Comparison of Aspirin and Clopidogrel with or without Proton Pump Inhibitors for the Secondary Prevention of Cardiovascular Events in Patients at High Risk for Gastrointestinal Bleeding

, 2011
Objective: This study was conducted to compare the risk of recurrent hospitalization for major gastrointestinal (GI) complications (peptic ulcer, bleeding, and perforation) in patients at high GI risk who require ongoing antiplatelet therapy (aspirin ...
蕭斐元;蔡憶文;黃文鴻;溫有汶;陳珮芬;郭耿南, HSIAO, SHARON FEI-YUAN;TSAI, YI-WEN;HUANG, WENG- FOUNG;WEN, YU-WEN;CHEN, PEI-FEN;KUO, KEN-NAN;HUANG, WENG-FOUNG   +1 more
core   +1 more source

Association Between CYP2C19 Genotype and P2Y12 Reaction Units in Patients Receiving Clopidogrel After Acute Ischemic Stroke: A Prospective, Observational Study

Pharmacotherapy: The Journal of Human Pharmacology and Drug Therapy, Volume 46, Issue 10, October 2026.
ABSTRACT Background Recurrent stroke accounts for substantial morbidity and mortality worldwide, with up to 25% of ischemic strokes occurring in patients with prior strokes. Dual antiplatelet therapy (DAPT) with aspirin and clopidogrel is standard for secondary prevention after minor acute ischemic stroke (AIS) or high‐risk transient ischemic attack ...
Rachael M. Stone, Annie Smith, Sonya Gunter, Andrew T. Weko, Carter Gottschalk, Cheyenne Lee, Allison Ramsey, Miah Perch Weatherspoon, Bradford B. Worrall   +8 more
wiley   +1 more source

Clinical Markers of Clopidogrel Resistance in Percutaneous Coronary-Treated Patients [PDF]

, 2019
Amaç: Antiplatelet tedavi güncel koroner arter hastalığının vazgeçilmez parçası olup, ADP inhibitörlerine karşı gelişen direnç hastaların istenmeyen kardiyovasküler olay yaşamalarına sebep olmaktadır.
Cem ÖZDE, Osman KAYAPİNAR, Özde, Cem, Kayapınar, Osman   +3 more
core   +1 more source

From Real World Data to Real Impact: A Co‐Medication Framework for Lung Cancer to Advance DDI Assessment and Patient‐Centric Drug Development

Clinical and Translational Science, Volume 19, Issue 10, October 2026.
ABSTRACT Lung cancer predominantly affects older adults who already experience comorbidities and are at increased risk of drug–drug interactions (DDIs) due to polypharmacy. Traditional DDI assessments often do not fully capture complex co‐medication patterns observed in real‐world practice due to the risk of introducing confounding factors.
Mareena Biju, HeeJae Choi, Shilpa Madari, Annie Carlisle, Ashish Sharma, Christina Kunz, Fenglei Huang   +6 more
wiley   +1 more source

A Prospective Cohort Study of Hard‐to‐Heal Chronic Foot and Leg Wounds Followed for up to 20 Weeks After Initiation of ReGenerating Tissue Agents (RGTA) Technology as an Add‐on to Optimal Local Care

International Wound Journal, Volume 23, Issue 10, October 2026.
ABSTRACT ReGenerating Tissue Agents (RGTA, trade name CACIPLIQ20) contain a structural analogue of heparan sulfates (HSs) that promotes tissue regeneration in hard‐to‐heal chronic wounds resistant to the best standard of care for 6 months or longer.
Serge Ynesta, Marion Mourgues, Chloé Geri, Martin Inizan, Denis Barritault, Frédéric Sedel, Jean‐Charles Kerihuel, Luc Téot   +7 more
wiley   +1 more source