Clinical Pharmacology &Therapeutics, Volume 119, Issue 5, Page 1382-1390, May 2026.Genetic variation has a significant impact on patients' response to medicines. Variations in important pharmacogenes have been evaluated in several studies and consequently led to international guidelines from clinical pharmacogenomics consortia. However, there are limited examples of these being implemented across the African continent despite the ...
Janine Scholefield +5 more
wiley +1 more source
Left ventricular fibrosarcoma in a 4‐year‐old labrador
Veterinary Record Case Reports, Volume 14, Issue 2, May 2026.Abstract A 4‐year‐old, male, neutered labrador presented for investigations into a single episode of collapse and an intracardiac mass. Echocardiography and computed tomography confirmed the presence of a large soft tissue mass within the left ventricular lumen, which nearly obstructed the left ventricular outflow tract.
Natalia Caldecott +4 more
wiley +1 more source
Dipstick proteinuria is an independent predictor of high on treatment platelet reactivity in patients on clopidogrel, but not aspirin, admitted for major adverse cardiovascular events. [PDF]
, 2014 The effectiveness of aspirin and clopidogrel in patients with chronic kidney disease (CKD) suffering from acute cardiovascular events is unclear. High on treatment platelet reactivity (HTPR) has been associated with worse outcomes.
Davila, Carlos D +6 more
core +2 more sources
Clinical pharmacology consultations and their implementation in clinical decision making
British Journal of Clinical Pharmacology, Volume 92, Issue 4, Page 1069-1077, April 2026.Aims One of the key roles of clinical pharmacologists is to work as consultants for other medical specialties. We wanted to investigate the characteristics of clinical pharmacology consultations, compare the types of consultations from different specialties, and evaluate how well the recommendations given were followed.
Mirjam Kauppila +2 more
wiley +1 more source
A study on the impact of CYP2C19 genotype and platelet reactivity assay on patients undergoing PCI
Indian Heart Journal, 2015 Background: A thorough understanding of the patient's genotype and their functional response to a medication is necessary for improving event free survival.
P.C. Rath +9 more
doaj +1 more source
Point-of-care platelet function assays demonstrate reduced responsiveness to clopidogrel, but not aspirin, in patients with Drug-Eluting Stent Thrombosis whilst on dual antiplatelet therapy [PDF]
, 2008 BackgroundTo test the hypothesis that point-of-care assays of platelet reactivity would demonstrate reduced response to antiplatelet therapy in patients who experienced Drug Eluting Stent (DES) ST whilst on dual antiplatelet therapy compared to matched ...
Hobson, Alex R. +4 more
core +1 more source
Safety and efficacy of intensive vs. guideline antiplatelet therapy in high-risk patients with recent ischemic stroke or transient ischemic attack: rationale and design of the Triple Antiplatelets for Reducing Dependency after Ischaemic Stroke (TARDIS) trial (ISRCTN47823388) [PDF]
, 2015 RATIONALE: The risk of recurrence following a stroke or transient ischemic attack is high, especially immediately after the event. HYPOTHESIS: Because two antiplatelet agents are superior to one in patients with non-cardioembolic events, more ...
Bath, Philip M.W. +13 more
core +1 more source
Identification of platelet hyper-reactivity measured with a portable device immediately after percutaneous coronary intervention predicts in stent thrombosis [PDF]
, 2007 Introduction: Platelet hyper-reactivity, despite a standard anti-thrombotic therapy, is a recognized risk factor for recurrent myocardial ischemia and in-stent thrombosis following PCI. We have investigated whether this detrimental condition, measured by
Andreassi, Maria Grazia +6 more
core +1 more source
Brazilian Journal of Cardiovascular SurgeryObjective: The aims of this study were to determine whether the detection of preoperative clopidogrel resistance in patients undergoing cardiac surgery while using clopidogrel could play a guiding role in the prediction of postoperative excessive ...
Mehmet Kizilay +5 more
doaj +1 more source
Diabetes mellitus and clopidogrel “resistance”
Clinical Management Issues, 2015 In our Department arrives a 75-year-old patient with hypertension, diabetes mellitus (DM) treated with hypoglycaemic drugs, dyslipidaemia and ischaemic heart disease post-acute myocardial infarction treated with triple coronary artery bypass surgery and subsequent percutaneous transluminal coronary angioplasty (PTCA).
Massarelli, Laura +3 more
openaire +4 more sources