Results 91 to 100 of about 30,781 (201)

Effects of genetic factors to stent thrombosis due to clopidogrel resistance after coronary stent placement

open access: yes, 2016
Stent thrombosis (ST) is considered as a multifactorial problem which is mostly occurs due to clopidogrel resistance. It may be due to some CYP450 enzyme deficiencies which play role in clopidogrel metabolism. Therefore the aim of this study is to detect
GÜNEY, AHMET İLTER
core   +2 more sources

Variability in ACT Response to Standard UFH Bolus During PCI: A Prospective Study on Determinants of Subtherapeutic Anticoagulation

open access: yesCatheterization and Cardiovascular Interventions, Volume 107, Issue 7, Page 2293-2303, June 1, 2026.
ABSTRACT Background Unfractionated heparin (UFH) remains the standard anticoagulant during percutaneous coronary intervention (PCI), with guidelines recommending a target activated clotting time (ACT) of ≥250 s. However, despite receiving a standardized bolus dose, many patients fail to achieve this target.
Manh Cuong Vu   +9 more
wiley   +1 more source

Two Case Reports of Percutaneous Intravascular Lithotripsy for the Treatment of Severe Coronary Artery Calcification

open access: yesClinical Case Reports, Volume 14, Issue 6, June 2026.
ABSTRACT Severe coronary calcification is a common challenge in percutaneous coronary intervention, often resulting in suboptimal stent expansion. Intravascular lithotripsy (IVL) employs acoustic pressure waves to fracture calcified plaques and increase procedural success.
Liang‐cai Guo   +3 more
wiley   +1 more source

Moderate Intensity Statins Plus Ezetimibe Combination Therapy Versus High Intensity Statins Monotherapy After Percutaneous Coronary Intervention: A Systematic Review and Meta‐Analysis

open access: yesClinical Cardiology, Volume 49, Issue 6, June 2026.
ABSTRACT Background High‐intensity statins are standard therapy after percutaneous coronary intervention (PCI) for acute coronary syndrome (ACS), yet tolerability concerns and residual cardiovascular risk remain important challenges. Moderate‐intensity statin therapy combined with ezetimibe has emerged as a potential alternative, although its ...
Emad Uddin Sajid   +12 more
wiley   +1 more source

A Comparative Analysis of Short‐Term Outcomes of Off Pump Coronary Artery Bypass Grafting Alone or Simultaneous Cerebral Revascularization: A Single‐Center Retrospective Study

open access: yesClinical Cardiology, Volume 49, Issue 6, June 2026.
The final flowchart categorizes subjects into two groups: the control group (n = 60) undergoing OPCABG alone and the combined cardiocerebrovascular revascularization group (n = 57). ABSTRACT Objectives The impact of simultaneous coronary artery bypass grafting (CABG) with cerebral revascularization versus CABG alone on perioperative complications and ...
Bo Li   +10 more
wiley   +1 more source

Evidence that pre-existent variability in platelet response to ADP accounts for 'clopidogrel resistance'

open access: yes, 2012
BACKGROUND: Clopidogrel is a widely used antithrombotic agent that inhibits the platelet P2Y(12) adenosine diphosphate (ADP) receptor. There is increasing interest in 'clopidogrel resistance'.
Frelinger, Andrew L. III   +8 more
core   +1 more source

Prevalence of clopidogrel resistance evaluated by the VASP method

open access: yes, 2010
BACKGROUND: Despite oral antiplatelet treatment a certain number of patients suffer adverse events while on therapy. Whether patients demonstrating low platelet inhibition in vitro are at increased risk for adverse events is unknown.
Dahl, Karine Haug
core  

Relation of genetic polymorphisms in the cytochrome P450 gene with clopidogrel resistance after drug-eluting stent implantation in Koreans

open access: yes, 2009
Clopidogrel is a prodrug that has to be converted to an active metabolite by hepatic cytochrome P450 (CYP) isoenzymes to inhibit platelet aggregation. Individual variability of platelet inhibition by clopidogrel suggests a possibility for genetic factors
이정명   +6 more
core   +1 more source

Effect of original and generic clopidogrel on prognosis in relation to different gene polymorphisms

open access: yesТерапевтический архив, 2014
AIM. To analyze the influence of clinical and pharmacogenetic factors on the risk of resistance to original or generic clopidogrel and that of cardiovascular events (CVE) during 12 months of follow-up. MATERIALS AND METHODS.
D F Mesitskaia   +4 more
doaj  

Assessing Functional Recovery in Ischemic Stroke: An Observational Study of Dual vs. Single Antiplatelet Therapy in Indian Patients

open access: yesHealth Science Reports, Volume 9, Issue 6, June 2026.
ABSTRACT Background and Aim In an aging population, stroke is a leading cause of morbidity and mortality. More than 80% of stroke cases in the elderly are ischemic strokes. Stroke is the sixth most common cause of disability globally and the second most common cause after ischemic heart disease (IHD).
Sohailuddin Mohammad   +10 more
wiley   +1 more source

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