Assessment of platelet function in patients with stroke using multiple electrode platelet aggregometry: a prospective observational study [PDF]
, 2016 Background There is a link between high on-treatment platelet reactivity (HPR) and adverse vascular events in stroke. This study aimed to compare multiple electrode platelet aggregometry (MEA), in healthy subjects and ischaemic stroke patients, and ...
A Feher +41 more
core +1 more source
Clopidogrel Resistance in Stroke Cases
Istanbul Medical Journal, 2019 Introduction:Clopidogrel treatment is one of the standard treatments in terms of reducing mortality and morbidity in patients with cerebrovascular disease diagnosed with large artery atherosclerosis. However, resistance to clopidogrel treatment is a significant problem today. In this study, we aimed to retrospectively investigate clopidogrel resistance
Nihan Çarçak +4 more
openaire +2 more sources
a new clinical algorithm comprising CYP2C19 pharmacogenetics and drug interactions [PDF]
, 2015 Purpose Response to clopidogrel varies widely with nonresponse rates ranging from 4% to 30%. A reduced function of the gene variant of the CYP2C19 has been associated with lower drug metabolite levels, and hence diminished platelet inhibition.
Ramadan, Wijdan H. +2 more
core +1 more source
Effect of original and generic clopidogrel on prognosis in relation to different gene polymorphisms
Терапевтический архив, 2014 AIM. To analyze the influence of clinical and pharmacogenetic factors on the risk of resistance to original or generic clopidogrel and that of cardiovascular events (CVE) during 12 months of follow-up. MATERIALS AND METHODS.
D F Mesitskaia +4 more
doaj
Clopidogrel Resistance: Current Issues
Journal of Enam Medical College, 2016 Antiplatelet agents are mainly used in the prevention and management of atherothrombotic complications. Dual antiplatelet therapy, combining aspirin and clopidogrel, is the standard care for patients having acute coronary syndromes or undergoing percutaneous coronary intervention according to the current ACC/AHA and ESC guidelines.
openaire +2 more sources
Advances in biotechnology: genomics and genome editing [PDF]
, 2017 Genomics, the study of genes, their functions and related techniques has become a crucial science for developing understanding of life processes and how they evolve.
Beccari, Tommaso +4 more
core +1 more source
Fundamental progress in investigating drug resistance with electronic multidrug compliance monitoring (e-MCM) [PDF]
, 2011 Current definitions of drug resistance are shaped by the pharmacotherapeutic fields they occurred in. They usually mention various contributing factors and refer either to the clinical or the biomarker level.
Arnet, I. +5 more
core
Clinical applications of personalized medicine: a new paradigm and challenge [PDF]
, 2017 The personalized medicine is an emergent and rapidly developing method of clinical practice that uses new technologies to provide decisions in regard to the prediction, prevention, diagnosis and treatment of disease.
Borro, Marina +7 more
core +1 more source
Frontiers in Neurology, 2019 Background and Purpose: Patients undergoing carotid artery stenting (CAS) who show low responsiveness to clopidogrel may have a higher risk of peri-procedural embolic events.
Jong-Won Chung +10 more
doaj +1 more source
The Personalization of Clopidogrel Antiplatelet Therapy: The Role of Integrative Pharmacogenetics and Pharmacometabolomics [PDF]
, 2017 Dual antiplatelet therapy of aspirin and clopidogrel is pivotal for patients undergoing percutaneous coronary intervention. However, the variable platelets reactivity response to clopidogrel may lead to outcome failure and recurrence of cardiovascular ...
Amin, Arwa M. +5 more
core +3 more sources