Results 71 to 80 of about 81,830 (325)

The carboxylate “gripper” of the substrate is critical for C‐4 stereo‐inversion by UDP‐glucuronic acid 4‐epimerase

FEBS Letters, EarlyView.
UDP‐glucuronic acid 4‐epimerase (UGAepi) catalyzes NAD+‐dependent interconversion of UDP‐glucuronic acid (UDP‐GlcA) and UDP‐galacturonic acid (UDP‐GalA) via C4‐oxidation, 4‐keto‐intermediate rotation, and C4‐reduction. Here, Borg et al. examined the role of the substrate's carboxylate group in the enzymic mechanism by analyzing NADH‐dependent reduction
Annika J. E. Borg, Laura De Cnop, Bernd Nidetzky   +2 more
wiley   +1 more source

Short-period Heartbeat Binaries from TESS Full-frame Images

The Astrophysical Journal Supplement Series
We identify 240 short-period ( P ≲ 10 days) binary systems in Transiting Exoplanet Survey Satellite data, 180 of which are heartbeat binaries. The sample is mostly a mix of A- and B-type stars and primarily includes eclipsing systems, where over 30% of ...
Siddhant Solanki, Agnieszka M. Cieplak, Jeremy Schnittman, John G. Baker, Thomas Barclay, Richard K. Barry, Veselin Kostov, Ethan Kruse, Greg Olmschenk, Brian P. Powell, Stela Ishitani Silva, Guillermo Torres   +11 more
doaj   +1 more source

On OB-type close binary stars [PDF]

Monthly Notices of the Royal Astronomical Society, 1987
On presente une compilation des donnees de masses, rayons, temperatures effectives et luminosites pour un ensemble de 31 binaires de type spectral O-B5. Ces donnees sont comparees aux resultats de calculs d'evolutions stellaires pour des etoiles massives avec parametrages de la perte de masse par vent stellaire et surdeversement ...
R. W. Hilditch, S. A. Bell
openaire   +2 more sources

Rewriting the dendritic cell code in cancer—from subset identity to immunotherapeutic design

FEBS Letters, EarlyView.
Dendritic cells (DCs) play central roles in cancer immunity but are often subverted by the tumor microenvironment. This review explores the diversity of DC subsets, their functional plasticity, and emerging therapeutic strategies to reprogram DCs for enhanced antitumor responses, including vaccines, in vivo targeting, and DC‐based immunotherapies ...
Estevão Carlos Silva Barcelos, Doriana Ricciuti, Giada Mondanelli, Marco Gargaro   +3 more
wiley   +1 more source

TIC 290061484: A Triply Eclipsing Triple System with the Shortest Known Outer Period of 24.5 Days

The Astrophysical Journal
We have discovered a triply eclipsing triple-star system, TIC 290061484, with the shortest known outer period, P _out , of only 24.5 days. This “eclipses” the previous record set by λ Tauri at 33.02 days, which held for 68 yr.
V. B. Kostov, S. A. Rappaport, T. Borkovits, B. P. Powell, R. Gagliano, M. Omohundro, I. B. Bíró, M. Moe, S. B. Howell, T. Mitnyan, C. A. Clark, M. H. Kristiansen, I. A. Terentev, H. M. Schwengeler, A. Pál, A. Vanderburg   +15 more
doaj   +1 more source

A large‐scale retrospective study in metastatic breast cancer patients using circulating tumour DNA and machine learning to predict treatment outcome and progression‐free survival

Molecular Oncology, EarlyView.
There is an unmet need in metastatic breast cancer patients to monitor therapy response in real time. In this study, we show how a noninvasive and affordable strategy based on sequencing of plasma samples with longitudinal tracking of tumour fraction paired with a statistical model provides valuable information on treatment response in advance of the ...
Emma J. Beddowes, Mario Ortega Duran, Solon Karapanagiotis, Alistair Martin, Meiling Gao, Riccardo Masina, Ramona Woitek, James Tanner, Fleur Tippin, Justine Kane, Jonathan Lay, Anja Brouwer, Stephen‐John Sammut, Suet‐Feung Chin, Davina Gale, Dana W. Y. Tsui, Sarah‐Jane Dawson, Nitzan Rosenfeld, Maurizio Callari, Oscar M. Rueda, Carlos Caldas   +20 more
wiley   +1 more source

Can the Central Compact Object in HESS J1731–347 Be Indeed the Lightest Neutron Star Observed?

The Astrophysical Journal
The exceptionally low mass of $0.7{7}_{-0.17}^{+0.2}{M}_{\odot }$ for the central compact object (CCO) XMMU J173203.3–344518 (XMMU J1732) in the supernova remnant (SNR) HESS J1731–347 challenges standard neutron star (NS) formation models.
S. R. Zhang, J. A. Rueda Hernandez, R. Negreiros   +2 more
doaj   +1 more source

Gas flow in Close Binary Star Systems [PDF]

, 2006
We first present a summary of our numerical work on accretion discs in close binary systems. Our recent studies on numerical simulations of the surface flow on the mass-losing star in a close binary star is then reviewed.
Kazutaka Oka, Izumi Hachisu, Henri M. J. Boffin, Takuya Matsuda   +3 more
openaire   +3 more sources

Impact of Binary Stars on Planet Statistics -- I. Planet Occurrence Rates, Trends with Stellar Mass, and Wide Companions to Hot Jupiter Hosts [PDF]

, 2019
Close binaries suppress the formation of circumstellar (S-type) planets and therefore significantly bias the inferred planet occurrence rates and statistical trends.
M. Moe, K. Kratter
semanticscholar   +1 more source

Targeted protein degradation in oncology: novel therapeutic opportunity for solid tumours?

Molecular Oncology, EarlyView.
Current anticancer therapies are limited by the occurrence of resistance and undruggability of most proteins. Targeted protein degraders are novel, promising agents that trigger the selective degradation of previously undruggable proteins through the recruitment of the ubiquitin–proteasome machinery. Their mechanism of action raises exciting challenges,
Noé Herbel, Sophie Postel‐Vinay
wiley   +1 more source