Results 81 to 90 of about 2,742,038 (335)

Epigenetic heterogeneity and plasticity in therapy‐induced tumor states through single‐cell multi‐omics

open access: yesMolecular Oncology, EarlyView.
Single‐cell multi‐omics reveals epigenetic heterogeneity across therapy‐adaptive tumor states, including quiescent/dormant, drug‐tolerant persister, and EMT‐like phenotypes. By linking regulatory features with state‐associated biomarkers, these approaches inform biomarker‐guided therapeutic strategies for evolving tumors.
Hee Jung Kim   +3 more
wiley   +1 more source

Merger Conditions of Population III Protostar Binaries

open access: yesThe Astrophysical Journal, 2023
Massive close binary stars with extremely small separations have been observed, and they are possible progenitors of gravitational-wave sources. The evolution of massive binaries in the protostellar accretion stage is key to understanding their formation
Takanobu Kirihara   +3 more
doaj   +1 more source

The evolution of close helium star to neutron star binaries [PDF]

open access: yesSymposium - International Astronomical Union, 2003
We present the evolution of helium stars in binary systems with a 1.4 M⊙ neutron-star companion which will produce double neutron-star binaries, i.e., systems with helium stars more massive than 2.5 M⊙. We found that mass transfer from helium star less massive than ~ 3.3 M⊙ will end up in a common-envelope phase.
Dewi, J.D.M., Pols, O.R.
openaire   +3 more sources

Circulating microRNA signatures of cachexia and cancer in Canis familiaris as a comparative oncology model for human disease

open access: yesMolecular Oncology, EarlyView.
Circulating microRNAs as biomarkers of cachexia and sex‐specific cancer in senior dogs. In 25 client‐owned dogs, four circulating miRNAs (miR‐15a, miR‐15b, miR‐16, miR‐140) were downregulated in cachexia, with miR‐16 the strongest individual biomarker (AUC = 0.899).
Soon‐Seok Park   +6 more
wiley   +1 more source

Detecting New Visual Binaries in Gaia DR3 with Gaia and Two Micron All Sky Survey (2MASS) Photometry. II. Speckle Observations of 16 Low-separation Systems

open access: yesThe Astronomical Journal
Here we present speckle observations of 16 low-separation ( s < 30 au) high-probability candidate binaries from the catalog by Medan et al., where secondaries typically lack astrometric solutions in Gaia. From these speckle observations, we find a second
Ilija Medan   +3 more
doaj   +1 more source

Stellar Properties of Observed Stars Stripped in Binaries in the Magellanic Clouds

open access: yesThe Astrophysical Journal, 2023
Massive stars (∼8–25 M _⊙ ) stripped of their hydrogen-rich envelopes via binary interaction are thought to be the main progenitors for merging neutron stars and stripped-envelope supernovae.
Y. Götberg   +8 more
doaj   +1 more source

Single‐cell DNA methylation profiling: Technologies, computation, and applications in precision oncology

open access: yesMolecular Oncology, EarlyView.
Single‐cell DNA methylation (scDNAme) profiling maps epimutational clonal evolution, revealing mechanisms of malignancy and therapeutic resistance across diverse cancer types. By providing a high‐resolution landscape of intratumoral heterogeneity, these technologies empower precise patient stratification, guide the development of enhanced ...
Ik Soo Kim
wiley   +1 more source

Can the Central Compact Object in HESS J1731–347 Be Indeed the Lightest Neutron Star Observed?

open access: yesThe Astrophysical Journal
The exceptionally low mass of $0.7{7}_{-0.17}^{+0.2}{M}_{\odot }$ for the central compact object (CCO) XMMU J173203.3–344518 (XMMU J1732) in the supernova remnant (SNR) HESS J1731–347 challenges standard neutron star (NS) formation models.
S. R. Zhang   +2 more
doaj   +1 more source

Terrestrial planet formation surrounding close binary stars [PDF]

open access: yes, 2006
Most stars reside in binary/multiple star systems; however, previous models of planet formation have studied growth of bodies orbiting an isolated single star. Disk material has been observed around both components of some young close binary star systems.
E. Quintana, J. Lissauer
semanticscholar   +1 more source

‘Swinging Dipoles’ in Magnetic Close Binary Stars [PDF]

open access: yesInternational Astronomical Union Colloquium, 1987
AbstractThe recently discovered phenomena in polars - Magnetic Close Binary Stars (MCBS), are discussed. Asynchronous MCBS are on the ‘propeller stage’ (which is analogous to the investigated one for neutron stars), and are synchronizing during ts ≲ 103 yr, being during this stage rapidly evolving, mass ejecting systems.
openaire   +1 more source

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