Results 81 to 90 of about 159,122 (291)

COMP–PMEPA1 axis promotes epithelial‐to‐mesenchymal transition in breast cancer cells

Molecular Oncology, EarlyView.
This study reveals that cartilage oligomeric matrix protein (COMP) promotes epithelial‐to‐mesenchymal transition (EMT) in breast cancer. We identify PMEPA1 (protein TMEPAI) as a novel COMP‐binding partner that mediates EMT via binding to the TSP domains of COMP, establishing the COMP–PMEPA1 axis as a key EMT driver in breast cancer.
Konstantinos S. Papadakos, Gilar Gorji‐bahri, Lejla Gradjan, Julia Zajac, Kacper Gil, Yvonne Thokozile Nduku, Anna M. Blom   +6 more
wiley   +1 more source

Deciphering transcriptional plasticity in pancreatic ductal adenocarcinoma reveals alterations in sensory neuron innervation

Molecular Oncology, EarlyView.
Pancreatic sensory neurons innervating healthy and PDAC tissue were retrogradely labeled and profiled by single‐cell RNA sequencing. Tumor‐associated innervation showed a dominant neurofilament‐positive subtype, altered mitochondrial gene signatures, and reduced non‐peptidergic neurons.
Elena Genova, Michele Montrone, Uday Rangaswamy, Francesco Diversi, Irene Schiavo, Denise Ferrarini, Roberta Di Florio, Irene Longo, Michele Coscia, Nicola Zamboni, Giorgia Demontis, Lisa Veghini, Vincenzo Corbo, Remo Sanges, Paul Heppenstall   +14 more
wiley   +1 more source

paired: A Statistical Framework for Detecting Stellar Binarity with Gaia RVs. I. Sensitivity to Unresolved Binaries

The Astrophysical Journal
Data Release 3 (DR3) from the Gaia Mission includes radial velocity measurements of over 33 million targets. Among many scientific applications, the overlap of this stellar sample with targeted exoplanet transit survey stars presents an opportunity to ...
Quadry Chance, Daniel Foreman-Mackey, Sarah Ballard, Andrew R. Casey, Trevor J. David, Adrian M. Price-Whelan   +5 more
doaj   +1 more source

Carbon-enhanced metal-poor stars: a window on AGB nucleosynthesis and binary evolution. II. Statistical analysis of a sample of 67 CEMP-$s$ stars [PDF]

, 2015
Many observed CEMP stars are found in binary systems and show enhanced abundances of $s$-elements. The origin of the chemical abundances of these CEMP-$s$ stars is believed to be accretion in the past of enriched material from a primary star in the AGB ...
Abate, C., Izzard, R. G., Karakas, A. I., Pols, O. R.   +3 more
core   +2 more sources

Analysing the significance of small conformational changes and low occupancy states in serial crystallographic data

FEBS Open Bio, EarlyView.
This protocol paper outlines methods to establish the success of a time‐resolved serial crystallographic experiment, by means of statistical analysis of timepoint data in reciprocal space and models in real space. We show how to amplify the signal from excited states to visualise structural changes in successful experiments.
Jake Hill, Yelyzaveta Pulnova, Elke De Zitter, Helen M. Ginn, Briony A. Yorke   +4 more
wiley   +1 more source

The Crucial Role of Third Body in Formation and Evolution of Contact Binary Systems: Evidence from CY Ari and IK Lyn

The Astrophysical Journal
CY Ari and IK Lyn are two eclipsing binary systems that share the same spectral type but exhibit significantly different metallicities. Based on the Wilson–Devinney (W-D) method, the first photometric solutions are obtained by analyzing the new complete ...
Hu-Shan Xu, Zhong-Tao Han, Wei-wei Na, Zhi-Hua Wang, Wen-wu Ma, Li-Ying Zhu   +5 more
doaj   +1 more source

Cutaneous Melanoma Drives Metabolic Changes in the Aged Bone Marrow Immune Microenvironment

Aging and Cancer, EarlyView.
Melanoma, the deadliest form of skin cancer, increasingly affects older adults. Our study reveals that melanoma induces changes in iron and lipid levels in the bone marrow, impacting immune cell populations and increasing susceptibility to ferroptosis.
Alexis E. Carey, Murilo Ramos Rocha, Cheyenne Palm, Vania Wang, Denys Balandin, Ethan Black, Kevin Y. Zhang, Fan Huang, Daniel J. Zabransky, Yash Chhabra, Mareike Peters, Gabriel Ghiaur, Ashani Weeraratna   +12 more
wiley   +1 more source

The IMF of Extremely Metal-Poor Stars and the Probe into the Star-Formation Process of the Milky Way

, 2007
We discuss the star formation history of the Galaxy, based on the observations of extremely metal-poor stars (EMP) in the Galactic halo, to gain an insight into the evolution and structure formation in the early universe.
Fujimoto, Masayuki Y., Habe, Asao, Komiya, Yutaka, Suda, Takuma   +3 more
core   +1 more source

Tracking Motor Progression and Device‐Aided Therapy Eligibility in Parkinson's Disease

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective To characterise the progression of motor symptoms and identify eligibility for device‐aided therapies in Parkinson's disease, using both the 5‐2‐1 criteria and a refined clinical definition, while examining differences across genetic subgroups.
David Ledingham, Sahana Sathyanarayana, Charlotte B. Stewart, Robyn Iredale, Victoria Foster, Debra Galley, Mark Baker, Nicola Pavese   +7 more
wiley   +1 more source

Deep Learning–Assisted Differentiation of Four Peripheral Neuropathies Using Corneal Confocal Microscopy

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Peripheral neuropathies contribute to patient disability but may be diagnosed late or missed altogether due to late referral, limitation of current diagnostic methods and lack of specialized testing facilities. To address this clinical gap, we developed NeuropathAI, an interpretable deep learning–based multiclass classification ...
Chaima Ben Rabah, Ioannis N. Petropoulos, Mark Stettner, Maryam Ferdousi, Uazman Alam, Nathan Efron, Ahmed Serag, Rayaz A. Malik   +7 more
wiley   +1 more source