Results 61 to 70 of about 232,426 (313)
Closed-Loop Opinion Formation [PDF]
Proceedings of the 2017 ACM on Web Science Conference, 2017 When information sources are moderated by recommender systems, so-called "filter bubbles" may restrict the diversity of content made available to users, potentially affecting their opinions. User opinions may in turn affect the output of recommender systems.
Larissa Spinelli, Mark Crovella
openaire +1 more source
Modelling stem cell differentiation related processes—A practical overview for biologists
FEBS Letters, EarlyView.Stem cell differentiation is complex and difficult to control experimentally. This review introduces suitable computational modelling approaches that can support stem cell research, from mechanistic ODE and abstract models to multiscale and deep learning methods.
Ricco Zeegelaar +4 more
wiley +1 more source
Design and analysis strategies for robust microbiome ageing research
FEBS Letters, EarlyView.The gut microbiome changes with age and associates with age‐related morbidity and mortality, establishing it as a potential biomarker and intervention target for ageing. Realising this potential requires methodological rigour, yet distinguishing biological signals from methodological artefacts remains challenging across cohorts. This review provides an
Mark Olenik +5 more
wiley +1 more source
Frontiers in Neuroscience, 2017 There is growing need for multichannel electrophysiological systems that record from and interact with neuronal systems in near real-time. Such systems are needed, for example, for closed loop, multichannel electrophysiological/optogenetic ...
Hananel Hazan +3 more
doaj +1 more source
Reconstructing enzyme evolution by protein engineering
FEBS Letters, EarlyView.Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler +2 more
wiley +1 more source
Conserved binding mode but diverse interfaces of MreC‐PBP2 interactions
FEBS Letters, EarlyView.The crystal structure of abMreC reveals a conserved two β‐barrel architecture and provides structural insights into its role within the bacterial elongasome. The abMreC–abPBP2 complex model identifies the molecular basis of MreC‐mediated PBP2 recognition, contributing to the regulation of peptidoglycan synthesis.
Hyunseok Jang +4 more
wiley +1 more source
Penerapan Kendali Fuzzy dalam Pengembangan Stimulasi Listrik untuk Mempercepat Penyembuhan Luka
Jurnal Nasional Teknik Elektro dan Teknologi InformasiPenyembuhan luka kronis masih menjadi tantangan medis karena keterbatasan terapi konvensional dalam mempercepat regenerasi jaringan. Stimulasi listrik (electrical stimulation, ES) dapat menjadi solusi efektif, tetapi ES open-loop belum mampu menyesuaikan
Rahmawati +5 more
doaj +1 more source
Closed-loop functional optogenetic stimulation
Nature Communications, 2018 Optogenetics is a promising alternative approach for restoration of neuromuscular function. Here the authors establish a closed-loop functional optogenetic stimulation for the control of limb joint angle in murine models, which demonstrates improved ...
Shriya S. Srinivasan +4 more
doaj +1 more source
Structure‐forward targeting of claudins with synthetic binders
FEBS Letters, EarlyView.Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley +1 more source