Results 61 to 70 of about 906,185 (256)

pH‐mediated activation of the lysosomal arginine sensor SLC38A9

FEBS Letters, EarlyView.
Cells monitor nutrient levels via the lysosomal transporter SLC38A9 to activate the mechanistic target of rapamycin complex 1 (mTORC1). This study reveals that SLC38A9 function is regulated by pH. We identified histidine 544 as a critical pH sensor that undergoes conformational changes to control amino acid efflux from lysosomes; therefore, it ...
Xuelang Mu, Ampon Sae Her, Tamir Gonen
wiley   +1 more source

Control analysis and experimental verification of a practical dc–dc boost converter

Journal of Electrical Systems and Information Technology, 2015
This paper presents detailed open loop and closed loop analysis on boost dc–dc converter for both voltage mode control and current mode control. Here the boost dc–dc converter is a practical converter considering all possible parasitic elements like ESR ...
Saswati Swapna Dash, Byamakesh Nayak
doaj   +1 more source

Stability of closed-loop fractional-order systems and definition of damping contours for the design of controllers [PDF]

, 2012
Fractional complex order integrator has been used since 1991 for the design of robust control-systems. In the CRONE control methodology, it permits the parameterization of open loop transfer function which is optimized in a robustness context.
Oustaloup, Alain, Pommier-Budinger, Valérie, Lanusse, Patrick   +2 more
core   +1 more source

Degradation mechanism of the von Willebrand factor A2 domain by nattokinase

FEBS Letters, EarlyView.
Nattokinase, a natto‐derived protease, exhibits potent antithrombotic effects. This study demonstrates that nattokinase directly cleaves the von Willebrand factor (vWF) A2 domain in vitro. Unlike the native regulator ADAMTS13, nattokinase degrades folded vWF independently of shear stress.
Ryuichi Hyakumoto, Masatomo So, Ayako Furukawa, Kenji Sugase   +3 more
wiley   +1 more source

Modulation of Homer1 EVH1 domain internal dynamics by putative autism‐associated mutations

FEBS Letters, EarlyView.
The putative autism‐associated M65I and S97L variants of the EVH1 domain of the postsynaptic scaffold protein Homer1 do not exhibit substantial changes in their overall structure or partner binding. Both of them, but especially the M65I variant, show altered internal dynamics relative to the wild‐type domain on the μs‐ms timescale, indicated by the ...
Fanni Farkas, Brigitta Maruzs, Zsófia E. Kálmán, Tomas Klumpler, Gyula Batta, Bálint Péterfia, Zoltán Gáspári   +6 more
wiley   +1 more source

Tunneling Magnetoresistance DC Current Transformer for Ion Beam Diagnostics

Sensors, 2021
In this paper, open loop and closed loop Tunneling Magnetoresistance (TMR) DC Current Transformers (DCCTs) for ion beam diagnostics are presented. The DCCTs employ MR sensors to measure the DC component of the accelerator’s ion beam.
Eman Azab, Yasser G. Hegazy, Hansjoerg Reeg, Marcus Schwickert, Klaus Hofmann   +4 more
doaj   +1 more source

Closed-Loop Opinion Formation [PDF]

Proceedings of the 2017 ACM on Web Science Conference, 2017
When information sources are moderated by recommender systems, so-called "filter bubbles" may restrict the diversity of content made available to users, potentially affecting their opinions. User opinions may in turn affect the output of recommender systems.
Larissa Spinelli, Mark Crovella
openaire   +1 more source

An unexpected alternative viologen electron mediator site in tungsten‐containing formate dehydrogenase

FEBS Letters, EarlyView.
An unexpected alternative interaction site for ethyl viologen was identified in formate dehydrogenase 1 from Methylorubrum extorquens. Combined mutagenesis, kinetic analysis, and docking revealed that aromatic residues near an iron–sulfur cluster enable flavin mononucleotide‐independent electron transfer, offering a framework for engineering improved ...
Eleni G. Poloniataki, Yong Hwan Kim
wiley   +1 more source

Closed-Loop FES Control of a Hybrid Exoskeleton during Sit-to-Stand Exercises: Concept and First Evaluation

Actuators, 2023
Rehabilitation of paralysis caused by a stroke or a spinal cord injury remains a complex and time-consuming task. This work proposes a hybrid exoskeleton approach combining a traditional exoskeleton and functional electrical stimulation (FES) as a ...
Chenglin Lyu, Pedro Truppel Morim, Bernhard Penzlin, Felix Röhren, Lukas Bergmann, Philip von Platen, Cornelius Bollheimer, Steffen Leonhardt, Chuong Ngo   +8 more
doaj   +1 more source

Phosphoinositides and inositol phosphates as molecular glues

FEBS Letters, EarlyView.
Inositol phosphates (IPs) and phosphoinositides (PIPs) regulate diverse eukaryotic processes. Beyond recruiting signaling proteins or acting as structural cofactors, recent studies suggest they mediate protein–protein interactions as natural molecular glues.
Aleshia Seaton‐Terry, Alexander J. Cutright, Mong Na Claire Loi, Jessica Martin, Joseph W. Gilligan, Jakub N. Kubina, Michael J. Arambula, Susanna Tanada Palmu, Daniella Zhou, Raymond D. Blind   +9 more
wiley   +1 more source