Results 101 to 110 of about 71,117 (287)

Dual targeting of RET and SRC synergizes in RET fusion‐positive cancer cells

Molecular Oncology, EarlyView.
Despite the strong activity of selective RET tyrosine kinase inhibitors (TKIs), resistance of RET fusion‐positive (RET+) lung cancer and thyroid cancer frequently occurs and is mainly driven by RET‐independent bypass mechanisms. Son et al. show that SRC TKIs significantly inhibit PAK and AKT survival signaling and enhance the efficacy of RET TKIs in ...
Juhyeon Son, Lily L. Remsing Rix, Bin Fang, Eric A. Welsh, Nicole V. Bremer, Valentina Foglizzo, Paola Roa, Nickole Sigcha‐Coello, Yi Liao, Eric B. Haura, Alexander Drilon, John M. Koomen, Emiliano Cocco, Uwe Rix   +13 more
wiley   +1 more source

Potential therapeutic targeting of BKCa channels in glioblastoma treatment

Molecular Oncology, EarlyView.
This review summarizes current insights into the role of BKCa and mitoBKCa channels in glioblastoma biology, their potential classification as oncochannels, and the emerging pharmacological strategies targeting these channels, emphasizing the translational challenges in developing BKCa‐directed therapies for glioblastoma treatment.
Kamila Maliszewska‐Olejniczak, Karolina Pytlak, Sandra Jaworowska, Bogusz Kulawiak, Piotr Bednarczyk   +4 more
wiley   +1 more source

ATF4‐mediated stress response as a therapeutic vulnerability in chordoma

Molecular Oncology, EarlyView.
We screened 5 chordoma cell lines against 100+ inhibitors of epigenetic and metabolic pathways and kinases and identified halofuginone, a tRNA synthetase inhibitor. Mechanistically halofuginone induces an integrated stress response, with eIF2alpha phosphorylation, activation of ATF4 and its target genes CHOP, ASNS, INHBE leading to cell death ...
Lucia Cottone, James Dunford, Eleanor Calcutt, Vicki Gamble, Filiz Senbabaoglu Aksu, Lorena Ligammari, Georgina Wherry, Giorgia Gaeta, John C. Christianson, Adrienne M. Flanagan, Udo Oppermann, Adam P. Cribbs   +11 more
wiley   +1 more source

Investigating the topology of interacting networks - Theory and application to coupled climate subnetworks

, 2011
Network theory provides various tools for investigating the structural or functional topology of many complex systems found in nature, technology and society.
A. Arenas, A. Gozolchiani, A. Vespignani, A.A. Tsonis, A.A. Tsonis, A.A. Tsonis, C.S. Bretherton, C.S. Zhou, C.S. Zhou, D. Hartmann, D. Majewski, D.J. Watts, E. Barreto, E. Langford, F.A. Rodrigues, G. Csárdi, G. Zamora-López, G. Zamora-López, H. C. H. Schultz, H. Riehl, H.J. Schellnhuber, J. F. Donges, J. Kurths, J. Kutzbach, J. Wallace, J.F. Donges, J.F. Donges, K. Yamasaki, L.C. Freeman, M. Kurant, M. Kurant, M. Kurant, M.A. Kramer, M.E.J. Newman, M.E.J. Newman, N. Marwan, N. Marwan, P. So, P.L. Flom, R. Albert, R. Heikes, R. Kistler, R. Parshani, R. Vautard, R.V. Donner, R.V. Donner, R.V. Donner, S. Bialonski, S. Boccaletti, S. Fortunato, S.V. Buldyrev, T. Schneider, T.M. Lenton, U. Brandes, Y. Zou   +54 more
core   +1 more source

LDAcoop: Integrating non‐linear population dynamics into the analysis of clonogenic growth in vitro

Molecular Oncology, EarlyView.
Limiting dilution assays (LDAs) quantify clonogenic growth by seeding serial dilutions of cells and scoring wells for colony formation. The fraction of negative wells is plotted against cells seeded and analyzed using the non‐linear modeling of LDAcoop.
Nikko Brix, Daniel Samaga, Katharina Gehr, Benedek Dankó, Mohamed Schumann, Guido Drexler, Ahmed Alnatsha, Georg Beyer, Ujjwal Mahajan, Martin Selmansberger, Julia Mayerle, Claus Belka, Horst Zitzelsberger, Kirsten Lauber   +13 more
wiley   +1 more source

Plecstatin inhibits hepatocellular carcinoma tumorigenesis and invasion through cytolinker plectin

Molecular Oncology, EarlyView.
The ruthenium‐based metallodrug plecstatin exerts its anticancer effect in hepatocellular carcinoma (HCC) primarily through selective targeting of plectin. By disrupting plectin‐mediated cytoskeletal organization, plecstatin inhibits anchorage‐dependent growth, cell polarization, and tumor cell dissemination.
Zuzana Outla, Jan Kosla, Magdalena Prechova, Lukas Frick, Patricia Bortel, Yasmin Borutzki, Andrea Bileck, Christopher Gerner, Samuel M. Meier‐Menches, Selma Osmanagic‐Myers, Martin Gregor   +10 more
wiley   +1 more source

Closeness of Some Graph Operations

Computing Open
Closeness is an important measure of network centrality. In this paper, we will calculate the closeness of graphs, created by using operations on graphs. We will prove a formula for the closeness of shadow graphs.
Chavdar Dangalchev
doaj   +1 more source

Persepsi Resiko Bencana Alam Ditinjau dari Sentralitas Jaringan Informasi Kebencanaan

Jurnal Ilmu Perilaku, 2018
This research aims to understand the risk perception of Merapi disaster in hazardous community, based on social network centrality. Quantitative approach with psychology scale is used to reveal perceptions of volcanic risk of Merapi, collaborated with ...
Sapta Widi Wusana, Rahmat Hidayat
doaj   +1 more source

Recurrent cancer‐associated ERBB4 mutations are transforming and confer resistance to targeted therapies

Molecular Oncology, EarlyView.
We show that the majority of the 18 analyzed recurrent cancer‐associated ERBB4 mutations are transforming. The most potent mutations are activating, co‐operate with other ERBB receptors, and are sensitive to pan‐ERBB inhibitors. Activating ERBB4 mutations also promote therapy resistance in EGFR‐mutant lung cancer.
Veera K. Ojala, Sini Ahonen, Sara Peltola, Aura Tuohisto‐Kokko, Olaya Esparta, Peppi Suominen, Anne Jokilammi, Iman Farahani, Deepankar Chakroborty, Nikol Dibus, Steffen Boettcher, Tomi T. Airenne, Mark S. Johnson, Lisa D. Eli, Klaus Elenius, Kari J. Kurppa   +15 more
wiley   +1 more source

Research on the spatial correlation structure of urban agglomeration economic growth and its threshold effects in Northeast China

Frontiers in Sustainable Cities
IntroductionThis study investigates the mechanisms through which the internal network structures of urban agglomerations influence economic growth.MethodsBased on panel data from 50 cities in Northeast China, spanning the period 2000 to 2019, a gravity ...
Qiao Li, Yan Zong, Zhen Quan, Jia Li
doaj   +1 more source