Results 1 to 10 of about 40,986 (311)

Whole genome sequence analysis reveals limited diversity among Clostridioides difficile ribotype 027 and 078 isolates collected in 22 hospitals in Berlin and Brandenburg, Germany [PDF]

Antimicrobial Resistance and Infection Control
Background Clostridioides difficile infections (CDI) present significant health risks and are among the most important nosocomial infections. Ribotype (RT) 027 poses a particular risk due to its proposed “hypervirulence”. Traditionally, C.
Esther E. Dirks, Vanessa Pfiffer, Genevieve Sohl, Fabian K. Berger, Ina Friesen, Johannes Friesen, Ralf Ignatius, Johannes Elias, Alexander Mellmann, Mardjan Arvand   +9 more
doaj   +2 more sources

Current and future approaches in Clostridioides Difficile management [PDF]

Romanian Journal of Infectious Diseases, 2022
Clostridioides Difficile is considered one of the main causes of the healthcare associated infections worldwide and the main cause of antibiotic-associated diarrhea, with forms of clinical disease ranging from mild to deadly.
George Sebastian Gherlan
doaj   +1 more source

Infective Endocarditis by Clostridioides and Clostridium Species—A Narrative Review

Antibiotics, 2023
Bacteria of the genus Clostridium are anaerobic Gram-positive spore-forming bacilli that include more than 200 species. Some of them are known to cause invasive infections and diseases caused by the production of toxins.
Petros Ioannou, Ioannis Kopidakis, Eirini Makraki, Stella Baliou, George Samonis   +4 more
doaj   +1 more source

Antigen-Specific vs. Neutralizing Antibodies Against Conditioned Media of Patients With Clostridioides difficile Infection: A Prospective Exploratory Study

Frontiers in Microbiology, 2022
The immunological response against Clostridioides difficile (C. difficile) is crucial for an improved understanding of disease mechanisms and the development of novel therapeutic strategies.
Sophie Roth, Philipp Jung, James Boone, Alexander Mellmann, Alexander Mellmann, Anna Nimmesgern, Sören L. Becker, Fabian K. Berger, Fabian K. Berger, Lutz von Müller, Lutz von Müller   +10 more
doaj   +1 more source

Variants at the MHC Region Associate With Susceptibility to Clostridioides difficile Infection: A Genome-Wide Association Study Using Comprehensive Electronic Health Records

Frontiers in Immunology, 2021
BackgroundClostridioides difficile is a major cause of healthcare-associated and community-acquired diarrhea. Host genetic susceptibility to Clostridioides difficile infection has not been studied on a large-scale.MethodsA total of 1,160 Clostridioides ...
Jiang Li, Yanfei Zhang, Alexandria L. Jilg, Donna M. Wolk, Harshit S. Khara, Amy Kolinovsky, David D. K. Rolston, Raquel Hontecillas, Josep Bassaganya-Riera, Marc S. Williams, Vida Abedi, Ming Ta Michael Lee   +11 more
doaj   +1 more source

Non–C. difficile Clostridioides Bacteremia in Intensive Care Patients, France

Emerging Infectious Diseases, 2021
Usually responsible for soft tissue infections, Clostridioides species can also cause bacteremia, life-threatening infections often requiring intensive care unit (ICU) admission.
Guillaume Morel, Guillaume Mulier, Etienne Ghrenassia, Moustafa Abdel Nabey, Yacine Tandjaoui, Achille Kouatchet, Laura Platon, Frédéric Pène, Anne-Sophie Moreau, Amelie Seguin, Damien Contou, Romain Sonneville, David Rousset, Muriel Picard, Guillaume Dumas, Djamel Mokart, Bruno Megarbane, Guillaume Voiriot, Isabelle Oddou, Elie Azoulay, Lucie Biard, Lara Zafrani   +21 more
doaj   +1 more source

Persistent systemic microbial translocation, inflammation, and intestinal damage during Clostridioides difficile infection [PDF]

, 2020
Background. Clostridioides difficile infection (CDI) might be complicated by the development of nosocomial bloodstream infection (n-BSI). Based on the hypothesis that alteration of the normal gut integrity is present during CDI, we evaluated markers of ...
Aversano, L., Battaglia, R., Bruno, G., Ciardi, M. R., Corazziari, E. S., de Angelis, M., Iera, J., Mascellino, M. T., Mastroianni, C. M., Miele, M. C., Morelli, S., Oliva, A., Venditti, M., Vullo, V.   +13 more
core   +1 more source

Foodborne Clostridioides Species: Pathogenicity, Virulence and Biocontrol Options

Microorganisms, 2023
Clostridioides species possess many virulence factors and alarming levels of muti-drug resistance which make them a significant risk to public health safety and a causative agent of livestock disease.
Mary Garvey
doaj   +1 more source

IL-27 induces LL-37/CRAMP expression from intestinal epithelial cells: implications for immunotherapy of Clostridioides difficile infection

Gut Microbes, 2021
Clostridioides difficile infection is currently the leading cause of nosocomial antibiotic-associated diarrhea and pseudomembranous colitis worldwide. Cathelicidins, a major group of natural antimicrobial peptides, have antimicrobial and immunomodulatory
Banglao Xu, Xianan Wu, Yi Gong, Ju Cao
doaj   +1 more source

Epidemiology of Clostridioides difficile Infection in Portugal: A Retrospective, Observational Study of Hospitalized Patients

Acta Médica Portuguesa, 2022
Introduction: Clostridioides difficile is the main cause of healthcare-associated diarrhea in Europe and North America. The aim of this study was to characterize the epidemiology and clinical burden of Clostridioides difficile infection among ...
Cláudia Nazareth, Inês Leitão, Ernestina Reis, Hugo Inácio, Filomena Martins, Elmano Ramalheira, Flávia Cunha, Carla Santos, Sara Lino, Hugo Moreira, Nadiya Kruptsala, Andrea Santos, Laura Paixão, Leonor Pássaro, Mónica Oleastro   +14 more
doaj   +1 more source