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Current and future approaches in Clostridioides Difficile management [PDF]

open access: yesRomanian Journal of Infectious Diseases, 2022
Clostridioides Difficile is considered one of the main causes of the healthcare associated infections worldwide and the main cause of antibiotic-associated diarrhea, with forms of clinical disease ranging from mild to deadly.
George Sebastian Gherlan
doaj   +1 more source

Infective Endocarditis by Clostridioides and Clostridium Species—A Narrative Review

open access: yesAntibiotics, 2023
Bacteria of the genus Clostridium are anaerobic Gram-positive spore-forming bacilli that include more than 200 species. Some of them are known to cause invasive infections and diseases caused by the production of toxins.
Petros Ioannou   +4 more
doaj   +1 more source

Molecular epidemiology and antimicrobial resistance of Clostridioides difficile in Germany, 2014–2019

open access: yesInternational Journal of Medical Microbiology, 2021
Clostridioides difficile is a Gram positive spore-forming rod and mainly responsible for nosocomial diarrhea in developed nations. Molecular and antimicrobial surveillance is important for monitoring the strain composition including genotypes of high ...
Ahmed Mohamed Mostafa Abdrabou   +9 more
doaj   +1 more source

Antigen-Specific vs. Neutralizing Antibodies Against Conditioned Media of Patients With Clostridioides difficile Infection: A Prospective Exploratory Study

open access: yesFrontiers in Microbiology, 2022
The immunological response against Clostridioides difficile (C. difficile) is crucial for an improved understanding of disease mechanisms and the development of novel therapeutic strategies.
Sophie Roth   +10 more
doaj   +1 more source

Variants at the MHC Region Associate With Susceptibility to Clostridioides difficile Infection: A Genome-Wide Association Study Using Comprehensive Electronic Health Records

open access: yesFrontiers in Immunology, 2021
BackgroundClostridioides difficile is a major cause of healthcare-associated and community-acquired diarrhea. Host genetic susceptibility to Clostridioides difficile infection has not been studied on a large-scale.MethodsA total of 1,160 Clostridioides ...
Jiang Li   +11 more
doaj   +1 more source

Clostridioides difficile infection: are the three currently used antibiotic treatment options equal from pharmacological and microbiological points of view?

open access: yesInternational Journal of Infectious Diseases, 2022
Recently, the recommendations for the treatment of Clostridioides difficile infection (CDI) have been updated. However, in addition to the clinical efficacy data, the drug of choice should ideally represent optimal antimicrobial stewardship, with an ...
Marcela Krutova, Mark Wilcox, Ed Kuijper
doaj   +1 more source

Non–C. difficile Clostridioides Bacteremia in Intensive Care Patients, France

open access: yesEmerging Infectious Diseases, 2021
Usually responsible for soft tissue infections, Clostridioides species can also cause bacteremia, life-threatening infections often requiring intensive care unit (ICU) admission.
Guillaume Morel   +21 more
doaj   +1 more source

Molecular epidemiology and antimicrobial resistance of Clostridioides difficile detected in chicken, soil and human samples from Zimbabwe

open access: yesInternational Journal of Infectious Diseases, 2020
Background: Clostridioides difficile is the major cause of infectious nosocomial diarrhoea in industrialized nations. Data on the occurrence of C. difficile in Africa, ribotype (RT) distribution, antimicrobial susceptibility patterns and potential ...
Fabian K. Berger   +6 more
doaj   +1 more source

Foodborne Clostridioides Species: Pathogenicity, Virulence and Biocontrol Options

open access: yesMicroorganisms, 2023
Clostridioides species possess many virulence factors and alarming levels of muti-drug resistance which make them a significant risk to public health safety and a causative agent of livestock disease.
Mary Garvey
doaj   +1 more source

IL-27 induces LL-37/CRAMP expression from intestinal epithelial cells: implications for immunotherapy of Clostridioides difficile infection

open access: yesGut Microbes, 2021
Clostridioides difficile infection is currently the leading cause of nosocomial antibiotic-associated diarrhea and pseudomembranous colitis worldwide. Cathelicidins, a major group of natural antimicrobial peptides, have antimicrobial and immunomodulatory
Banglao Xu, Xianan Wu, Yi Gong, Ju Cao
doaj   +1 more source

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