Results 121 to 130 of about 40,986 (311)

A Real-World Study on the Clinical Characteristics, Outcomes, and Relationship between Antibiotic Exposure and Clostridioides difficile Infection

Antibiotics
Clostridioides difficile is a Gram-positive bacteria that causes nosocomial infections, significantly impacting public health. In the present study, we aimed to describe the clinical characteristics, outcomes, and relationship between antibiotic exposure
B. Vintilă, A. Arseniu, C. Morgovan, Anca Butuca, Victoria Bîrluțiu, C. Dobrea, L. Rus, S. Ghibu, A. Bereanu, Rares Arseniu, Ioana Roxana Codru, Mihai Sava, Felicia Gabriela Gligor   +12 more
semanticscholar   +1 more source

Controversies in the Prevention and Treatment of Clostridioides difficile Infection in Adults: A Narrative Review

Microorganisms, 2023
Clostridioides difficile remains a problematic pathogen resulting in significant morbidity and mortality, especially for high-risk groups that include immunocompromised patients.
Taryn B Bainum, K. Reveles, R. Hall, Kelli Cornell, C. Alvarez   +4 more
semanticscholar   +1 more source

Epidemiological characteristics of infections caused by bacteria Clostridioides difficile toxins [PDF]

Srpski Arhiv za Celokupno Lekarstvo
Introduction/Objective. Clostridioides difficile is one of the most common infectious agents and an important cause of infections among hospitalized patients, often resulting in severe and potentially fatal outcomes.
Koprivica Marko, Đekić-Malbaša Jelena
doaj   +1 more source

Domperidone Protects Cells from Intoxication with Clostridioides difficile Toxins by Inhibiting Hsp70-Assisted Membrane Translocation

Toxins, 2023
Clostridioides difficile infections cause severe symptoms ranging from diarrhea to pseudomembranous colitis due to the secretion of AB-toxins, TcdA and TcdB.
Maria Braune-Yan, Jinfang Jia, Mary Wahba, Johannes Schmid, Panagiotis Papatheodorou, Holger Barth, Katharina Ernst   +6 more
doaj   +1 more source

Pharmacokinetic and pharmacodynamic evaluation of sulbactam‐durlobactam in a critically ill patient on continuous venovenous hemofiltration infected with carbapenem‐resistant Acinetobacter baumannii‐calcoaceticus complex

Pharmacotherapy: The Journal of Human Pharmacology and Drug Therapy, EarlyView.
Abstract Background Drug databases currently do not provide dosing guidance for sulbactam‐durlobactam in continuous renal replacement therapy. Herein, we present the first in vivo pharmacokinetic (PK) evaluation of sulbactam‐durlobactam during continuous venovenous hemofiltration (CVVH) in a patient with carbapenem‐resistant Acinetobacter baumannii ...
Wesley D. Kufel, Nabil Zeineddine, Aliaa Fouad, Hanna F. Roenfanz, Ryan K. Shields, Ellen G. Kline, Jameson Warner, Kathleen Hanrahan, Joseph L. Kuti   +8 more
wiley   +1 more source

A network of small RNAs regulates sporulation initiation in Clostridioides difficile

EMBO Journal, 2023
The obligate anaerobic, enteric pathogen Clostridioides difficile persists in the intestinal tract by forming antibiotic‐resistant endospores that contribute to relapsing and recurrent infections. Despite the importance of sporulation for C.
Manuela Fuchs, Vanessa Lamm-Schmidt, Tina Lenče, Johannes Sulzer, Arne Bublitz, Janet Wackenreuter, Milan Gerovac, T. Strowig, F. Faber   +8 more
semanticscholar   +1 more source

Impact of ribotype on Clostridioides difficile diagnostics [PDF]

European Journal of Clinical Microbiology & Infectious Diseases, 2019
AbstractThis study investigates the performance of diagnostic methods for detection of Clostridioides difficile infection in Sweden, including impact of PCR ribotype on diagnostic performance. Between 2011 and 2016, a total of 17,878 stool samples from 26 laboratories were tested by either well-type enzyme immunoassays (EIAs), membrane bound EIAs, cell
Kristina Rizzardi, Andreas Matussek, Thomas Åkerlund, Torbjörn Norén   +3 more
openaire   +3 more sources

Phage therapy for Clostridioides difficile infection

Frontiers in Immunology, 2022
Clostridioides difficile is endemic in the intestinal tract of healthy people. However, it is responsible for many healthcare-associated infections, such as nosocomial diarrhea following antibiotic treatment. Importantly, there have been cases of unsuccessful treatment and relapse related to the emergence of highly virulent strains of C.
Kosuke Fujimoto, Kosuke Fujimoto, Satoshi Uematsu, Satoshi Uematsu   +3 more
openaire   +3 more sources

Clostridioides difficile Infection after Antibiotics Treatments for Acute Appendicitis in a 2-year-old Girl: A Case Report [PDF]

, 2022
Clostridioides difficile infection (CDI) is an intestinal infection caused by intestinal dysbiosis due to exposure to antibiotics. We describe the case of a 2-year-old girl who developed CDI after antibiotic treatment for acute appendicitis.
Fujita, Yuji, Yamaguchi, Takeshi, Yoshihara, Shigemi, Yuasa, Naoki   +3 more
core   +1 more source

Proton pump inhibitor concomitant use to prevent oxaliplatin‐induced peripheral neuropathy: Clinical retrospective cohort study

Pharmacotherapy: The Journal of Human Pharmacology and Drug Therapy, EarlyView.
Abstract Background Oxaliplatin‐induced peripheral neuropathy (OIPN) is a major clinical challenge because it leads to discontinuation of chemotherapy. Omeprazole, a proton pump inhibitor (PPI), has been shown to prevent OIPN in a rat model. Therefore, we aimed to test whether the concomitant use of a PPI reduces oxaliplatin discontinuation due to OIPN.
Keisuke Mine, Takehiro Kawashiri, Kohei Mori, Yusuke Mori, Haruna Ishida, Hibiki Kudamatsu, Shunsuke Fujita, Mayako Uchida, Takaaki Yamada, Nobuaki Egashira, Ichiro Ieiri, Satoru Koyanagi, Shigehiro Ohdo, Takao Shimazoe, Daisuke Kobayashi   +14 more
wiley   +1 more source