Results 11 to 20 of about 40,986 (311)

Clostridioides difficile, a New “Superbug”

Microorganisms, 2023
Clostridioides difficile is a Gram-positive, spore-forming, anaerobic bacterium. The clinical features of C. difficile infections (CDIs) can vary, ranging from the asymptomatic carriage and mild self-limiting diarrhoea to severe and sometimes fatal ...
R. Markovska, G. Dimitrov, R. Gergova, L. Boyanova   +3 more
semanticscholar   +4 more sources

Effect of fecal microbiota, live-jslm (REBYOTA [RBL]) on health-related quality of life in patients with recurrent Clostridioides difficile infection: Results from the PUNCH CD3 clinical trial [PDF]

Open Forum Infectious Diseases, 2023
BACKGROUND: Recurrence of METHODS: This was a secondary analysis of a randomized, double-blind, placebo-controlled phase 3 study (PUNCH CD3). The disease-specific RESULTS: Findings were analyzed in a total of 185 patients (RBL, n = 128 [69.2%]; placebo ...
Bancke, Lindy L, Dubberke, Erik R, Feuerstadt, Paul, Fillbrunn, Mirko, García-Horton, Viviana, Garey, Kevin W, Guo, Amy, Harvey, Adam, Tillotson, Glenn S, Wang, Hongjue, Yang, Min   +10 more
core   +3 more sources

Extraintestinal Clostridioides difficile infection

IDCases, 2020
Clostridioides (Clostridium) difficile is the major cause of healthcare antibiotic-associated diarrhoea. However, extra-intestinal manifestations of Clostridioides (Clostridium) difficile infection (CDI) (including bacteremia and tissue infection) are ...
Zhao Hai, Lei Peng Zhen, Ma Juan, Yang Fan, Cang Jin Rong, Liang Jing Yao, Zhang Li Xia   +6 more
doaj   +3 more sources

Mortality Attributable to Clostridioides difficile Infection: The Rising Burden of Disease in European Countries

Medicina
Background and Objectives: Clostridioides difficile infection is a major public health issue, being among the main causes of mortality due to healthcare-associated diarrhea.
Irena Ilic, Ivana Zivanovic Macuzic, Milena Ilic   +2 more
doaj   +2 more sources

Clostridioides difficile infection: an update.

Infezioni in Medicina
Clostridioides difficile (C. difficile) is a Gram-positive, spore-forming anaerobic bacterium emerged as a leading cause of diarrhea globally. CDI's (Clostridioides difficile infection) impact on healthcare systems is concerning due to high treatment ...
Federica Salvati, Francesca Catania, Rita Murri, Massimo Fantoni, Carlo Torti   +4 more
semanticscholar   +3 more sources

VE303, a Defined Bacterial Consortium, for Prevention of Recurrent Clostridioides difficile Infection: A Randomized Clinical Trial.

Journal of the American Medical Association (JAMA), 2023
Importance The effect of rationally defined nonpathogenic, nontoxigenic, commensal strains of Clostridia on prevention of Clostridioides difficile infection (CDI) is unknown.
T. Louie, Y. Golan, S. Khanna, D. Bobilev, Nathalie Erpelding, Candida Fratazzi, M. Carini, Rajita Menon, Mary M. Ruisi, J. Norman, J. Faith, B. Ollé, Minran Li, J. Silber, D. Pardi   +14 more
semanticscholar   +1 more source

Plasmids of Clostridioides difficile

Current Opinion in Microbiology, 2022
Plasmids are ubiquitous in the bacterial world. In many microorganisms, plasmids have been implicated in important aspects of bacterial physiology and contribute to horizontal gene transfer. In contrast, knowledge on plasmids of the enteropathogen Clostridioides difficile is limited, and there appears to be no phenotypic consequence to carriage of many
Smits, W.K., Roseboom, A.M., Corver, J.
openaire   +3 more sources

Bile salt hydrolases shape the bile acid landscape and restrict Clostridioides difficile growth in the murine gut

Nature Microbiology, 2023
Bile salt hydrolases encoded by the gut microbiome shape the bile acid pool, including microbial conjugated bile acids, which impact Clostridioides difficile infection in the murine gut.
M. H. Foley, Morgan E. Walker, A. Stewart, Sarah O’Flaherty, Emily C. Gentry, Shakshi Patel, Violet V. Beaty, Garrison Allen, Meichen Pan, J. B. Simpson, Caroline D. Perkins, Molly E. Vanhoy, Michael K. Dougherty, Sarah K. McGill, Ajay S. Gulati, P. Dorrestein, E. Baker, M. Redinbo, R. Barrangou, C. Theriot   +19 more
semanticscholar   +1 more source

Clinical Practice Guideline by the Infectious Diseases Society of America (IDSA) and Society for Healthcare Epidemiology of America (SHEA): 2021 Focused Update Guidelines on Management of Clostridioides difficile Infection in Adults.

Clinical Infectious Diseases, 2021
This clinical practice guideline is a focused update on management of Clostridioides difficile infection (CDI) in adults specifically addressing the use of fidaxomicin and bezlotoxumab for the treatment of CDI.
Stuart Johnson, V. Lavergne, Andrew M. Skinner, A. Gonzales-Luna, K. Garey, C. Kelly, M. Wilcox   +6 more
semanticscholar   +1 more source

Clostridioides difficile [PDF]

Trends in Microbiology, 2018
Clostridioides difficile is a spore-forming, anaerobic, intestinal pathogen that causes severe diarrhea that can lead to death. In 2011, C. difficile infected ∼500000 people in the USA and killed ∼29000 people. C. difficile infection (CDI) is the most common healthcare-related infection in the USA, leading to increased healthcare costs of $4.8 billion.
Brindar K, Sandhu, Shonna M, McBride
openaire   +2 more sources