Results 21 to 30 of about 40,986 (311)
SER-109, an Oral Microbiome Therapy for Recurrent Clostridioides difficile Infection.
New England Journal of Medicine, 2022 BACKGROUND Current therapies for recurrent Clostridioides difficile infection do not address the disrupted microbiome, which supports C. difficile spore germination into toxin-producing bacteria.
P. Feuerstadt +22 more
semanticscholar +1 more source
Antibiotics, 2023 Clostridioides difficile remains an important public health threat, globally. Since the emergence of the hypervirulent strain, ribotype 027, new strains have been reported to cause C.
Crystal Liu +4 more
semanticscholar +1 more source
Therapeutic Advances in Gastroenterology, 2023 Background: Microbiota-based treatments reduce the incidence of recurrent Clostridioides difficile infections (rCDIs), but prospectively collected safety data needed to broaden patient access and protect public health have been limited.
Christine Lee +8 more
semanticscholar +1 more source
Diagnostic Methods of Clostridioides difficile Infection and Clostridioides difficile Ribotypes in Studied Sample [PDF]
Antibiotics, 2021 Background: Clostridioides (Clostridium) difficile is the most common nosocomial pathogen and antibiotic-related diarrhea in health-care facilities. Over the last few years, there was an increase in the incidence rate of C. difficile infection cases in Slovakia.
Elena Novakova +3 more
openaire +3 more sources
Cochrane Database of Systematic Reviews, 2023 BACKGROUND Clostridioides difficile (formerly known as Clostridium difficile) is a bacterium that can cause potentially life-threatening diarrheal illness in individuals with an unhealthy mixture of gut bacteria, known as dysbiosis, and can cause ...
N. Minkoff +7 more
semanticscholar +1 more source
ACG Clinical Guidelines: Prevention, Diagnosis, and Treatment of Clostridioides difficile Infections
American Journal of Gastroenterology, 2021 Clostridioides difficile infection occurs when the bacterium produces toxin that causes diarrhea and inflammation of the colon. These guidelines indicate the preferred approach to the management of adults with C.
C. Kelly +6 more
semanticscholar +1 more source
Iron Regulation in Clostridioides difficile [PDF]
Frontiers in Microbiology, 2018 The response to iron limitation of several bacteria is regulated by the ferric uptake regulator (Fur). The Fur-regulated transcriptional, translational and metabolic networks of the Gram-positive, pathogen Clostridioides difficile were investigated by a combined RNA sequencing, proteomic, metabolomic and electron microscopy approach.
Mareike Berges +17 more
openaire +7 more sources
JAMA Network Open, 2023 This phase 3, open-label, single-arm trial assesses the safety of SER-109 and the rate of recurrent Clostridioides difficile infection after administration of SER-109 following symptom resolution after antibiotic treatment among adults.
M. Sims +23 more
semanticscholar +1 more source
Frontiers in Public Health, 2021 Clostridioides difficile infection possesses a significant economical burden, specifically in the inpatient and rural settings. Fecal Microbiota Transplant has been used for treatment of recurrent Clostridioides difficile but its utility is limited by ...
Krishna Vedala +3 more
doaj +1 more source
Porcine Colostrum Protects the IPEC-J2 Cells and Piglet Colon Epithelium against Clostridioides (syn. Clostridium) difficile Toxin-Induced Effects [PDF]
, 2020 Clostridioides difficile toxins are one of the main causative agents for the clinical symptoms observed during C. difficile infection in piglets. Porcine milk has been shown to strengthen the epithelial barrier function in the piglet’s intestine and may ...
Grześkowiak, Łukasz +7 more
core +1 more source