Results 71 to 80 of about 36,665 (260)

Protection from Lethal Clostridioides difficile Infection via Intraspecies Competition for Cogerminant

mBio, 2021
Antibiotic-associated colitis is often caused by infection with the bacterium Clostridioides difficileC ...
Jhansi L. Leslie, Matthew L. Jenior, Kimberly C. Vendrov, Alexandra K. Standke, Madeline R. Barron, Tricia J. O’Brien, Lavinia Unverdorben, Pariyamon Thaprawat, Ingrid L. Bergin, Patrick D. Schloss, Vincent B. Young   +10 more
doaj   +1 more source

Deliverable D-JRP15–FED-AMR-WP3.2: Overview of genetic overlap between human and non-human Clostridiodes difficile isolates [PDF]

, 2022
This deliverable and the associated task aims to contribute to increase knowledge regarding the true impact of C. difficile as a zoonotic agent and its transmission networks, by evaluating the extent of genetic overlap and potential transmission between ...
Abdel-Glil, Mostafa Youssef, Alves, Frederico, Cabal Rosel, Adriana, Castro, Rita, Dost, Ines, Maurischat, Sven, Mazuet, Christelle, Oleastro, Monica, Persson, Soren, Schlotzek, Anissa, Seyboldt, Christian, Tenson, Tanel   +11 more
core   +2 more sources

Diversity and Dosage Determine the Efficacy of the Probiotic SYN‐53 in Allergic Rhinoconjunctivitis: A Randomized, Double‐Blind, Placebo‐Controlled Trial

Allergy, EarlyView.
The probiotic food supplement SYN‐53 has previously shown efficacy in managing allergic rhinoconjunctivitis (ARC), with its high bacterial diversity and dosage hypothesized as key drivers. This study on 166 subjects aimed to confirm this hypothesis by comparing the effects of SYN‐53, a low dose variant (SYN‐53‐LD), a low diversity variant (SYN‐4), and ...
Karl‐Christian Bergmann, Torsten Zuberbier   +1 more
wiley   +1 more source

GrapeTree : visualization of core genomic relationships among 100,000 bacterial pathogens [PDF]

, 2016
Current methods struggle to reconstruct and visualise the genomic relationships of ≥100,000 bacterial genomes. GrapeTree facilitates the analyses of allelic profiles from 10,000's of core genomes within a web browser window.
Zhou, Zhemin, Alikhan, Nabil-Fareed, Sergeant, Martin J., Luhmann, Nina, Vaz, Catia, Francisco, Alexandre P., Carrico, Joao Andre, Achtman, Mark   +7 more
core   +11 more sources

Infant Acid‐Suppressant Medication, C. difficile Colonisation, and Childhood Body Mass Index in a Canadian Cohort

Acta Paediatrica, EarlyView.
ABSTRACT Aim To determine relationships between paediatric use of acid‐suppressive medications (ASMs) (proton pump inhibitors (PPI) and histamine‐2 receptor antagonists (H2RA)) and preschool body mass index (BMI) and mediation by C. difficile colonisation. Methods ASMs were parent‐reported at age 3, 6 and 12 months in 1025 infants from the CHILD Cohort
Sarah L. Bridgman, Kelsea M. Drall, Amanda A. Lau, Hein M. Tun, Nadia P. Morales‐Lizcano, Hien Q. Huynh, Piushkumar J. Mandhane, Theo J. Moraes, Elinor Simons, Stuart E. Turvey, Padmaja Subbarao, James A. Scott, Anita L. Kozyrskyj   +12 more
wiley   +1 more source

Phage therapy for Clostridioides difficile infection

Frontiers in Immunology, 2022
Clostridioides difficile is endemic in the intestinal tract of healthy people. However, it is responsible for many healthcare-associated infections, such as nosocomial diarrhea following antibiotic treatment. Importantly, there have been cases of unsuccessful treatment and relapse related to the emergence of highly virulent strains of C.
Kosuke Fujimoto, Kosuke Fujimoto, Satoshi Uematsu, Satoshi Uematsu   +3 more
openaire   +3 more sources

The Bacterial Gut Microbiota of Adult Patients Infected, Colonized or Noncolonized by Clostridioides difficile

Microorganisms, 2020
Gut microbiota composition in patients with Clostridioides difficile colonization is not well investigated. We aimed to identify bacterial signatures associated with resistance and susceptibility to C.
Monique J. T. Crobach, Quinten R. Ducarmon, Elisabeth M. Terveer, Celine Harmanus, Ingrid M. J. G. Sanders, Kees M. Verduin, Ed J. Kuijper, Romy D. Zwittink   +7 more
doaj   +1 more source

Phages and human health: More than idle hitchhikers [PDF]

, 2019
Bacteriophages, or phages, are viruses that infect bacteria and archaea. Phages have diverse morphologies and can be coded in DNA or RNA and as single or double strands with a large range of genome sizes. With the increasing use of metagenomic sequencing
Baldridge, Megan T, Handley, Scott A, Lawrence, Dylan   +2 more
core   +2 more sources

Improving Clinical Outcomes of Encapsulated Faecal Microbiota Transplantation for Clostridioides difficile Infection Through Empirical Donor Selection and Optimised Dosing: A Quality Improvement Study

Alimentary Pharmacology &Therapeutics, EarlyView.
In a large‐scale, multiple‐site Danish faecal microbiota transplantation (FMT) system, the cure rates in patients with Clostridioides difficile infection treated with encapsulated FMT were improved following exclusion of three low‐performing donors and implementation of a two‐dose FMT regimen.
Sara Ellegaard Paaske, Simon Mark Dahl Baunwall, Tone Rubak, Nina Rågård, Jens Kelsen, Mette Mejlby Hansen, Anders Bergh Lødrup, Søren Lyhne, Emilie Glavind, Christa Marie Culmback Fernis, Stine Hald, Lise Tornvig Erikstrup, Lars Vinter‐Jensen, Simon Lal, Susan Mikkelsen, Christian Erikstrup, Jens Frederik Dahlerup, Christian Lodberg Hvas   +17 more
wiley   +1 more source

Impact of ribotype on Clostridioides difficile diagnostics [PDF]

European Journal of Clinical Microbiology & Infectious Diseases, 2019
AbstractThis study investigates the performance of diagnostic methods for detection of Clostridioides difficile infection in Sweden, including impact of PCR ribotype on diagnostic performance. Between 2011 and 2016, a total of 17,878 stool samples from 26 laboratories were tested by either well-type enzyme immunoassays (EIAs), membrane bound EIAs, cell
Kristina Rizzardi, Andreas Matussek, Thomas Åkerlund, Torbjörn Norén   +3 more
openaire   +3 more sources