Results 71 to 80 of about 28,268 (242)

Gut microbiome in pediatric acute pancreatitis and Crohn's disease versus irritable bowel syndrome and healthy controls

Journal of Pediatric Gastroenterology and Nutrition, EarlyView.
Abstract Objectives Pediatric acute pancreatitis (AP), Crohn's disease (CD), and irritable bowel syndrome (IBS) are associated with gut dysbiosis, but differences and similarities between conditions are unknown. We hypothesized that gut microbial ecology would differ across these disorders. Methods Stool was collected from 120 subjects (AP [n = 30], CD
Neha R. Santucci, Chinenye R. Dike, Jenny Hellmann, Nicholas J. Ollberding, Qing Duan, Philip Minar, Lee A. Denson, David B. Haslam, Daniel Castillo, Maisam Abu‐El‐Haija   +9 more
wiley   +1 more source

Pediatric Clostridiodes difficile infection with toxic megacolon successfully treated with fecal microbiota transplantation

JPGN Reports, EarlyView.
Abstract The rising incidence of pediatric Clostridioides difficile infection (CDI), particularly in medically complex patients, calls for novel, individualized treatments. While fecal microbiota transplantation (FMT) is well‐described for recurrent CDI, this report describes the first pediatric case of fulminant CDI with toxic megacolon successfully ...
Dana McCarney, Pamela Chen, Jenna Simes, Stacy A. Kahn   +3 more
wiley   +1 more source

A mixed methods analysis of clostridioides difficile infection and implementation of a quality improvement intervention in public sector hospitals in Cape Town, South Africa

, 2022
Philosophiae Doctor - PhDBackground: Clostridioides difficile or Clostridium difficile infection (CDI), is a global health threat known for devastating outbreaks, high-cost complications, readmissions and mortality.
Legenza, Laurel
core  

Perioperative Risks of Concurrent Pancreatic and Hepatic Resections for Neuroendocrine Tumors

Journal of Surgical Oncology, EarlyView.
ABSTRACT Background and Objectives Pancreatic neuroendocrine tumors (pNETs) account for 1%–2% of pancreatic tumors, with an increasing incidence. The safety of concurrent pancreas‐liver resections remains uncertain. This study evaluated the national outcomes of concurrent pancreatectomy and liver‐directed surgery for pNETs. Methods ACS‐NSQIP (2019–2023)
Amir Ebadinejad, Ashrita Raghuram, Sophia Xiao, Ethan Angle, Hassan Aziz   +4 more
wiley   +1 more source

Artificial Intelligence‐Driven Natural Product Drug Discovery: From Computational Genome Mining to Clinical Translation

Medicinal Research Reviews, EarlyView.
ABSTRACT Natural products (NPs) have historically yielded numerous therapeutic agents, yet their integration into modern drug discovery has been constrained by chemical complexity, low abundance, laborious dereplication, and limited target annotation.
Antonio Lavecchia
wiley   +1 more source

Clostridioides difficile

Acta Médica Grupo Ángeles, 2023
Thomas J. Sandora, Larry K. Kociolek
  +5 more sources

Microbiota Transplantation Effectively Treats Immune Checkpoint Inhibitor‐Associated Colitis: A Multi‐Center, Retrospective Case Series

Microbiota Medicine Research, EarlyView.
ABSTRACT Background Immune‐mediated colitis is an adverse effect of therapy with immune checkpoint inhibitors (ICIs). This study aims to evaluate the efficacy and safety of washed microbiota transplantation (WMT) in patients with ICI‐associated colitis.
Mengyu Huang, Yaping Liu, Hong Lu, Weihong Wang, Huiying Gao, Junlan Qiu, Yan Jin, Qian Ren   +7 more
wiley   +1 more source

Clostridioides difficile infection after appendectomy: An analysis of short-term outcomes from the NSQIP database.

, 2022
BACKGROUND: Clostridioides difficile infection can be a significant complication in surgical patients. The purpose of this study was to describe the incidence and impact on outcomes of Clostridioides difficile infection in adult patients after ...
Kumar, Mohineesh, Brahmamdam, Pavan, Peters, Mallory, Karabon, Patrick   +3 more
core   +1 more source

Competitive SELEX Strategy for High‐Affinity Aptamer Isolation and Enhanced Biosensing

Small, EarlyView.
A novel competitive SELEX strategy was developed to isolate high‐affinity aptamers by using a lower‐affinity competitor during the selection process. This approach enabled the identification of an aptamer with exceptional binding affinity, significantly improving target detection sensitivity.
Jiuxing Li, Jiaxuan Xiao, Jimmy Gu, Zhen Zhang, Yingfu Li   +4 more
wiley   +1 more source

Clostridioides difficileの分子疫学的解析並びにtoxin遺伝子陽性群でのリスク因子の解析 [PDF]

, 2019
In this study, we investigated all Clostridioides difficile strains isolated from stool samples in Nagasaki University Hospital between January 2012 and December 2014.
Uno, Naoki, Yanagihara, Katsunori, 岡田, 侑也, Kaku, Norihito, Okada, Yuya, Hasegawa, Hiroo, Kosai, Kosuke, Morinaga, Yoshitomo   +7 more
core   +1 more source