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Clostridioides difficile infection diagnosis
Annales de Biologie CliniqueClostridioides difficile is a Gram-positive, spore-forming anaerobic enteropathogen responsible for a wide spectrum of clinical diseases ranging from mild diarrhoea to pseudomembranous colitis. It is the first cause of healthcare-associated diarrhoeas, but community-associated Clostridioides difficile infections (CDI) are increasingly reported in ...
Jeanne, Couturier +3 more
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Clostridioides (Clostridium) difficile
2021This chapter evaluates Clostridioides (Clostridium) difficile, a gram-positive anaerobic spore-forming bacillus found in colon flora. When C. difficile is induced to produce exotoxins (A/B) symptomatic disease (i.e., diarrhea/colitis) follows. The clinical spectrum of infection ranges from watery toxigenic diarrhea to invasive transmural colitis.
Cheston B. Cunha, Burke A. Cunha
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Diagnosis and Management of Clostridioides difficile
American Journal of GastroenterologyClostridioides difficile infection (CDI) is challenging to diagnose and treat. Recently published studies and clinical observations have improved our understanding around diagnostic testing and positioning of antibiotics and microbiota-based therapies.
Colleen R. Kelly, Paul Feuerstadt
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Antibiotic Resistances of Clostridioides difficile
The rapid evolution of antibiotic resistance in Clostridioides difficile and the consequent effects on prevention and treatment of C. difficile infections (CDIs) are a matter of concern for public health. Antibiotic resistance plays an important role in driving C. difficile epidemiology.Patrizia, Spigaglia +2 more
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[Clostridioides difficile infections].
Nederlands tijdschrift voor geneeskunde, 2023Here, we describe the epidemiology, diagnostics, and treatment of Clostridioides difficile infection (CDI) in the primary health care setting. CDI is traditionally considered as a healthcare associated infection. However, infections with onset in the community represent a large proportion of CDI.
Joffrey, van Prehn +3 more
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Foodborne transmission of Clostridioides difficile
Current Opinion in Gastroenterology, 2020The epidemiology of Clostridioides difficile infection (CDI) is changing, with increasing rates of community-acquired infections. In light of recent advances in understanding C. difficile transmission networks with whole-genome sequencing, new routes of spread outside the hospital need to be considered.
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Comparative Genomics of Clostridioides difficile
Clostridioides difficile, a Gram-positive spore-forming anaerobic bacterium, has rapidly emerged as the leading cause of nosocomial diarrhoea in hospitals. The availability of large numbers of genome sequences, mainly due to the use of next-generation sequencing methods, has undoubtedly shown their immense advantages in the determination of C ...Sandra, Janezic +2 more
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Clostridioides difficile Infections: Prevention and Treatment Strategies
Clostridioides difficile is the most common causative agent of antibiotic-associated diarrhea. This spore forming, obligate anaerobic, gram-positive bacillus is becoming responsible for an increasing number of infections worldwide, both in community and in hospital settings, whose severity can vary widely from an asymptomatic infection to a lethal ...Levy, Elvira Ingrid +3 more
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Clostridioides difficile toxins: mechanisms of action and antitoxin therapeutics
Nature Reviews Microbiology, 2021Shannon Lynn Kordus, Dana Borden Lacy
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