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Clostridioides difficile colitis
2021Clostridioides difficile (C. diff) is the most frequently reported nosocomial pathogen and a leading cause of morbidity and mortality in hospitalized patients. In the USA 435,000 infections are annually reported, with 29,000 deaths. C. diff infection quadruples hospitalization costs.
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Antimicrobial resistance in Clostridioides difficile
European Journal of Clinical Microbiology & Infectious Diseases, 2021Antimicrobial resistance (AMR) in Clostridioides difficile remains a significant threat to global healthcare systems, not just for the treatment of C. difficile infection (CDI), but as a reservoir of AMR genes that could be potentially transferred to other pathogens. The mechanisms of resistance for several antimicrobials such as metronidazole and MLSB-
O'Grady, K., Knight, D.R., Riley, T.V.
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Clostridioides difficile in Children
Infectious Disease Clinics of North AmericaAfter a significant increase in pediatric Clostridioides difficile infection (CDI) in the United States over the past 2 decades, incidence has declined over the past 5 y. Community-associated CDI incidence is 3 times higher than healthcare facility-associated CDI in children, but sources of community acquisition are poorly defined.
Larry K, Kociolek +2 more
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Clostridioides difficile Sporulation
Some members of the Firmicutes phylum, including many members of the human gut microbiota, are able to differentiate a dormant and highly resistant cell type, the endospore (hereinafter spore for simplicity). Spore-formers can colonize virtually any habitat and, because of their resistance to a wide variety of physical and chemical insults, spores can ...Mónica, Serrano +2 more
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Clostridioides difficile in bat guano
Comparative Immunology, Microbiology and Infectious Diseases, 2019Bats are associated with the emergence of several mammalian diseases. Their sessional migration, and tendency to form large colonies in close proximity to human habitats enables effective intra- and inter-species transmission of pathogens. Clostridioides difficile is an important enteric pathogen in humans and animals; however, the source of its ...
Petra Bandelj +6 more
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Microscopy methods for Clostridioides difficile
AnaerobeMicroscopic technologies including light and fluorescent, transmission electron microscopy (TEM), scanning electron microscopy (SEM), and cryo-electron microscopy have been widely utilized to visualize Clostridioides difficile at the molecular, cellular, community, and structural biology level. This comprehensive review summarizes the microscopy tools (
Chenlin Hu, Kevin W. Garey
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Clostridioides difficile infection diagnosis
Annales de Biologie CliniqueClostridioides difficile is a Gram-positive, spore-forming anaerobic enteropathogen responsible for a wide spectrum of clinical diseases ranging from mild diarrhoea to pseudomembranous colitis. It is the first cause of healthcare-associated diarrhoeas, but community-associated Clostridioides difficile infections (CDI) are increasingly reported in ...
Jeanne, Couturier +3 more
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Clostridioides (Clostridium) difficile
2021This chapter evaluates Clostridioides (Clostridium) difficile, a gram-positive anaerobic spore-forming bacillus found in colon flora. When C. difficile is induced to produce exotoxins (A/B) symptomatic disease (i.e., diarrhea/colitis) follows. The clinical spectrum of infection ranges from watery toxigenic diarrhea to invasive transmural colitis.
Cheston B. Cunha, Burke A. Cunha
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Diagnosis and Management of Clostridioides difficile
American Journal of GastroenterologyClostridioides difficile infection (CDI) is challenging to diagnose and treat. Recently published studies and clinical observations have improved our understanding around diagnostic testing and positioning of antibiotics and microbiota-based therapies.
Colleen R. Kelly, Paul Feuerstadt
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Antibiotic Resistances of Clostridioides difficile
The rapid evolution of antibiotic resistance in Clostridioides difficile and the consequent effects on prevention and treatment of C. difficile infections (CDIs) are a matter of concern for public health. Antibiotic resistance plays an important role in driving C. difficile epidemiology.Patrizia, Spigaglia +2 more
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