Results 221 to 230 of about 143,361 (253)

Reduced Vancomycin Susceptibility in Clostridioides difficile is Associated with Lower Rates of Initial Cure and Sustained Clinical Response.

Clinical Infectious Diseases
BACKGROUND Epidemiologic studies have shown decreasing vancomycin susceptibility among clinical Clostridioides difficile isolates, but the impact on patient outcomes is unknown.
Taryn A. Eubank, Chetna Dureja, K. Garey, J. Hurdle, A. Gonzales-Luna   +4 more
semanticscholar   +1 more source

Diagnosis and Management of Clostridioides difficile

American Journal of Gastroenterology
Clostridioides difficile infection (CDI) is challenging to diagnose and treat. Recently published studies and clinical observations have improved our understanding around diagnostic testing and positioning of antibiotics and microbiota-based therapies.
Colleen R. Kelly, Paul Feuerstadt
openaire   +2 more sources

Comparative Genomics of Clostridioides difficile

Clostridioides difficile, a Gram-positive spore-forming anaerobic bacterium, has rapidly emerged as the leading cause of nosocomial diarrhoea in hospitals. The availability of large numbers of genome sequences, mainly due to the use of next-generation sequencing methods, has undoubtedly shown their immense advantages in the determination of C ...
Sandra, Janezic, Julian R, Garneau, Marc, Monot   +2 more
openaire   +2 more sources

Antibiotic Resistances of Clostridioides difficile

The rapid evolution of antibiotic resistance in Clostridioides difficile and the consequent effects on prevention and treatment of C. difficile infections (CDIs) are a matter of concern for public health. Antibiotic resistance plays an important role in driving C. difficile epidemiology.
Patrizia, Spigaglia, Paola, Mastrantonio, Fabrizio, Barbanti   +2 more
openaire   +2 more sources

Foodborne transmission of Clostridioides difficile

Current Opinion in Gastroenterology, 2020
The epidemiology of Clostridioides difficile infection (CDI) is changing, with increasing rates of community-acquired infections. In light of recent advances in understanding C. difficile transmission networks with whole-genome sequencing, new routes of spread outside the hospital need to be considered.
openaire   +2 more sources

Phocaeicola vulgatus shapes the long-term growth dynamics and evolutionary adaptations of Clostridioides difficile

Cell Host and Microbe
SUMMARY Clostridioides difficile can transiently or persistently colonize the human gut, posing a risk for infections. This colonization is influenced by complex molecular and ecological interactions with the human gut microbiota.
Jordy Evan Sulaiman, Jaron Thompson, Pak Lun Kevin Cheung, Yili Qian, J. Mill, Isabella James, Hanhyeok Im, Eugenio I. Vivas, Judith A. Simcox, Ophelia S. Venturelli   +9 more
semanticscholar   +1 more source

Clostridioides difficile

2021
Henning Sommermeyer, Jacek Piątek
openaire   +1 more source

Clostridioides difficile Infections: Prevention and Treatment Strategies

Clostridioides difficile is the most common causative agent of antibiotic-associated diarrhea. This spore forming, obligate anaerobic, gram-positive bacillus is becoming responsible for an increasing number of infections worldwide, both in community and in hospital settings, whose severity can vary widely from an asymptomatic infection to a lethal ...
Levy, Elvira Ingrid, Dinleyici, Meltem, Dinleyici, Ener, Vandenplas, Yvan   +3 more
openaire   +3 more sources

Clostridioides difficile toxins: mechanisms of action and antitoxin therapeutics

Nature Reviews Microbiology, 2021
Shannon L Kordus, D Borden Lacy, Lacy D Borden   +2 more
exaly  

Clinical complications in patients with primary and recurrent Clostridioides difficile infection: A real-world data analysis

SAGE Open Medicine, 2021
Paul Feuerstadt, Mena Boules, David N Dahdal   +2 more
exaly