Results 211 to 220 of about 143,361 (253)

A multivalent mRNA-LNP vaccine protects against Clostridioides difficile infection

Science
Clostridioides difficile infection (CDI) is an urgent public health threat with limited preventative options. In this work, we developed a messenger RNA (mRNA)–lipid nanoparticle (LNP) vaccine targeting C. difficile toxins and virulence factors.
M. Alameh, Alexa Semon, Nile U Bayard, Yi-Gen Pan, Garima Dwivedi, James J. Knox, Rochelle C. Glover, Paula C. Rangel, Ceylan Tanes, K. Bittinger, Qianxuan She, Haitao Hu, Srinivisa Reddy Bonam, Jeffrey R. Maslanka, P. Planet, Ahmed M. Moustafa, Benjamin Davis, A. Chevrier, Mitchell Beattie, Houping Ni, Gabrielle S Blizard, Emma E Furth, R. Mach, M. Lavertu, Mark A. Sellmyer, Ying K. Tam, Michael C. Abt, D. Weissman, J. Zackular   +28 more
semanticscholar   +1 more source

Clostridioides difficile in Children

Infectious Disease Clinics of North America
After a significant increase in pediatric Clostridioides difficile infection (CDI) in the United States over the past 2 decades, incidence has declined over the past 5 y. Community-associated CDI incidence is 3 times higher than healthcare facility-associated CDI in children, but sources of community acquisition are poorly defined.
Larry K, Kociolek, Thomas J, Sandora, Preeti, Mehrotra   +2 more
openaire   +2 more sources

Oral Vancomycin for Prevention of Recurrent Clostridioides difficile Infection

JAMA Network Open
This randomized clinical trial examines whether prophylactic oral vancomycin vs placebo reduces recurrent Clostridioides difficile infection in adults receiving antibiotics for another indication.
J. Keating, Tinghui Xu, Mary Beth Graham, M. Ramesh, S. Khanna, Jonah Dixon, Ashley E. Kates, Kendra Haight, Jiwei Zhao, Christopher Saddler, Nasia Safdar   +10 more
semanticscholar   +1 more source

The Impact of Diet on Clostridioides difficile Infection: A Review

Journal of Infectious Diseases
Clostridioides difficile poses a significant public health challenge as it is the leading cause of antibiotic-associated diarrhea and is associated with significant morbidity and mortality.
Melissa Castro, Heidi J. Silver, Keith Z. Hazleton, C. Lozupone, M. Nicholson   +4 more
semanticscholar   +1 more source

Clostridioides difficile Sporulation

Some members of the Firmicutes phylum, including many members of the human gut microbiota, are able to differentiate a dormant and highly resistant cell type, the endospore (hereinafter spore for simplicity). Spore-formers can colonize virtually any habitat and, because of their resistance to a wide variety of physical and chemical insults, spores can ...
Mónica, Serrano, Diogo, Martins, Adriano O, Henriques   +2 more
openaire   +2 more sources

Clostridioides difficile in bat guano

Comparative Immunology, Microbiology and Infectious Diseases, 2019
Bats are associated with the emergence of several mammalian diseases. Their sessional migration, and tendency to form large colonies in close proximity to human habitats enables effective intra- and inter-species transmission of pathogens. Clostridioides difficile is an important enteric pathogen in humans and animals; however, the source of its ...
Petra Bandelj, Tea Knapič, Joyce Rousseau, Monika Podgorelec, Primož Presetnik, Modest Vengust, J. Scott Weese   +6 more
openaire   +2 more sources

Clostridioides difficile infection diagnosis

Annales de Biologie Clinique
Clostridioides difficile is a Gram-positive, spore-forming anaerobic enteropathogen responsible for a wide spectrum of clinical diseases ranging from mild diarrhoea to pseudomembranous colitis. It is the first cause of healthcare-associated diarrhoeas, but community-associated Clostridioides difficile infections (CDI) are increasingly reported in ...
Jeanne, Couturier, Muriel, Ehmig, Imane, Mostaghat, Frédéric, Barbut   +3 more
openaire   +2 more sources

Microscopy methods for Clostridioides difficile

Anaerobe
Microscopic technologies including light and fluorescent, transmission electron microscopy (TEM), scanning electron microscopy (SEM), and cryo-electron microscopy have been widely utilized to visualize Clostridioides difficile at the molecular, cellular, community, and structural biology level. This comprehensive review summarizes the microscopy tools (
Chenlin Hu, Kevin W. Garey
openaire   +2 more sources

A randomized controlled trial of efficacy and safety of Fecal Microbiota Transplant for preventing recurrent Clostridioides difficile infection.

Clinical Infectious Diseases
BACKGROUND Clostridioides difficile infection (CDI) is the most common cause of healthcare-associated infections in US hospitals with 15%-30% of patients experiencing recurrence.
D. Drekonja, Aasma Shaukat, Yuan Huang, Jane H. Zhang, Andrew R. Reinink, S. Nugent, Jason A. Dominitz, A. Davis-Karim, D. Gerding, T. Kyriakides   +9 more
semanticscholar   +1 more source

Clostridioides (Clostridium) difficile

2021
This chapter evaluates Clostridioides (Clostridium) difficile, a gram-positive anaerobic spore-forming bacillus found in colon flora. When C. difficile is induced to produce exotoxins (A/B) symptomatic disease (i.e., diarrhea/colitis) follows. The clinical spectrum of infection ranges from watery toxigenic diarrhea to invasive transmural colitis.
Cheston B. Cunha, Burke A. Cunha
openaire   +1 more source