Results 101 to 110 of about 1,730,491 (239)

Tigecycline combination therapy for fulminant Clostridioides difficile infection: an Australian experience

Internal Medicine Journal, EarlyView.
Abstract Background Recent European Society of Clinical Microbiology and Infection and Australasian Society of Infectious Diseases Clostridioides difficile infection (CDI) management guidelines endorse the addition of intravenous tigecycline in patients who are progressing to fulminant infection.
Emma Bishop, Tanya Ravipati, Steven Mileto, Eugene Athan, Dena Lyras, Ravindranath Tiruvoipati   +5 more
wiley   +1 more source

N Engl J Med [PDF]

BACKGROUNDEfforts to prevent Clostridioides difficile infection continue to expand across the health care spectrum in the United States. Whether these efforts are reducing the national burden of C.

core  

Clostridioides difficile Enteritis Induced Anastomotic Rupture: A Case Report and Literature Review

Case Reports in Surgery, 2020
Background. A 76-year-old male patient who suffered small bowel anastomotic dehiscence believed to be a complication provoked by Clostridioides difficile enteritis. Case Presentation. The patient was a 76-year-old male who underwent small bowel resection
David R. Velez, Mentor Ahmeti
doaj   +1 more source

Immunometabolic Modulation by Low‐Dose Sodium Butyrate: PI3K/Akt/mTOR Signalling Orchestrates Macrophage Polarization to Protect Against Clostridioides difficile Colitis

Immunology, EarlyView.
Clostridioides difficile toxins TcdA and TcdB enter intestinal epithelial cells (IECs) via specific receptors, disrupt tight‐junction integrity and activate PI3K/Akt/mTOR signalling, promoting inflammasome assembly and IL‐1β release. Toxin‐induced IEC apoptosis further weakens the epithelial barrier.
Sisi Zhang, Zhou Jingxiang, Caixia Tan, Yuanyuan Xiao, Ju Zou, Biyue Tian, Anhua Wu, Chunhui Li   +7 more
wiley   +1 more source

Risk factors for further recurrences of Clostridioides difficile infection at the first and second recurrence: a retrospective cohort

BMC Infectious Diseases
Background Recurrent Clostridioides difficile infection is most effectively treated with faecal microbiota transplantation. Swedish and European guidelines suggest faecal microbiota transplantation after a first or second recurrence, respectively.
Måns Stefansson, Oscar Bladh, Piotr Nowak, Lars Rombo, Magnus Hedenstierna, Johan Ursing   +5 more
doaj   +1 more source

The Oral‐Gut Axis: Bidirectional Interactions Between Microbiome and Diseases

Journal of Periodontal Research, EarlyView.
This study aims to summarize the mechanisms underlying ectopic colonization of the gut by oral pathobionts and the microbial and host factors that regulate this process. ABSTRACT Increased colonization of typically oral microorganisms is frequently observed in the gut mucosa or lumen of individuals with gastrointestinal disorders, including patients ...
Shinya Ebihara, Nobuhiko Kamada
wiley   +1 more source

Association between proton pump inhibitor therapy and clostridium difficile infection: a contemporary systematic review and meta-analysis. [PDF]

, 2012
Introduction Emerging epidemiological evidence suggests that proton pump inhibitor (PPI) acid-suppression therapy is associated with an increased risk of Clostridium difficile infection (CDI).
Sutton, AJ, Imad M. Tleyjeh (104252), Tannir Mohamad Al, Alex J Sutton, AlGhamdi, M, Muhammad Riaz (104236), Bin Abdulhak, AA, Ibrahim Talal, Mushabab AlGhamdi (112556), Baddour, LM, Alasmari Faisal A., A. A. Bin Abdulhak (7656569), Abed Allehibi, Talal Ibrahim (112568), Allehibi, A., Alasmari, FA, Faisal A. Alasmari (112549), F. A. Alasmari (7656575), A. R. Khan (3951662), AlGhamdi Mushabab, A. AlLehibi (7656593), Khan, AR, Al Tannir, M, Tleyjeh, IM, I. M. Tleyjeh (7656566), AlGhamdi, M., Abed AlLehibi (112573), Khan, A. R., Alex J. Sutton (112577), Garbati Musa A., L. M. Baddour (7656596), Aref A Bin Abdulhak, M. A. Garbati (7656578), M. Al Tannir (7656584), Bin Abdulhak, A. A., M. AlGhamdi (7656581), Erwin, P. J., Imad M Tleyjeh, Khan Abdur Rahman, Tleyjeh, I. M., Patricia J Erwin, T. Ibrahim (7656590), Muhammad Riaz, Abdur Rahman Khan (104234), Garbati, MA, Allehibi, A, Bin Abdulhak Aref A., Erwin, PJ, Sutton Alex J., M. Riaz (7656572), Riaz Muhammad, Musa A Garbati, Alasmari, F. A., Patricia J. Erwin (104246), Talal Ibrahim, Abdur Rahman Khan, Ibrahim, T., Mushabab AlGhamdi, A. J. Sutton (7648487), Faisal A Alasmari, Ibrahim, T, Mohamad Al Tannir (112562), Mohamad Al Tannir, Erwin Patricia J., Larry M Baddour, Baddour Larry M., Al Tannir, M., P. J. Erwin (7656587), Aref A. Bin Abdulhak (104239), Garbati, M. A., Larry M. Baddour (104249), Riaz, Muhammad, Riaz, M, Tleyjeh Imad M., Baddour, L. M., Sutton, A. J., Musa A. Garbati (104244), AlLehibi Abed   +77 more
core   +1 more source

Clostridioides difficile infection after appendectomy: An analysis of short-term outcomes from the NSQIP database.

, 2022
BACKGROUND: Clostridioides difficile infection can be a significant complication in surgical patients. The purpose of this study was to describe the incidence and impact on outcomes of Clostridioides difficile infection in adult patients after ...
Kumar, Mohineesh, Brahmamdam, Pavan, Peters, Mallory, Karabon, Patrick   +3 more
core   +1 more source

Can Physicians Heal Themselves?

Microbiota Medicine Research, EarlyView.
Xiaoqian Zhang
wiley   +1 more source

Periodontitis and Inflammatory Bowel Diseases: Mechanistic Evidence

Journal of Periodontal Research, EarlyView.
This review aims to provide a conceptual framework for understanding the mechanistic interplay between periodontitis and IBD, with a particular emphasis on the microbial and immunological crosstalk linking the oral cavity and the gastrointestinal tract.
Ana Paula V. Colombo, Adriana M. de Oliveira, Nobuhiko Kamada, Sho Kitamoto   +3 more
wiley   +1 more source