Results 101 to 110 of about 1,849,474 (227)

Trends and regional variation in antibiotic prescribing by dentists in Finland, 2012–2025: A register‐based study

European Journal of Oral Sciences, EarlyView.
Abstract This nationwide register‐based study aimed to investigate trends and regional variation in the number of antibiotic prescriptions issued by dentists in Finland from 2012 to 2025. Data on reimbursed outpatient antibiotic prescriptions dispensed by Finnish pharmacies were used.
Terhi Laitala, Emma Aarnio, Katariina Tuomilinna, Eero Raittio, Jukka Leinonen   +4 more
wiley   +1 more source

Aerial dissemination of Clostridium difficile spores [PDF]

, 2008
YesClostridium difficile-associated diarrhoea (CDAD) is a frequently occurring healthcare-associated infection, which is responsible for significant morbidity and mortality amongst elderly patients in healthcare facilities. Environmental contamination is
Sleigh, P.A., Snelling, Anna M., Beggs, Clive B., Smith, Caroline F., Kerr, Kevin G., Banfield, Kathleen R., Roberts, K.   +6 more
core   +3 more sources

Tigecycline combination therapy for fulminant Clostridioides difficile infection: an Australian experience

Internal Medicine Journal, EarlyView.
Abstract Background Recent European Society of Clinical Microbiology and Infection and Australasian Society of Infectious Diseases Clostridioides difficile infection (CDI) management guidelines endorse the addition of intravenous tigecycline in patients who are progressing to fulminant infection.
Emma Bishop, Tanya Ravipati, Steven Mileto, Eugene Athan, Dena Lyras, Ravindranath Tiruvoipati   +5 more
wiley   +1 more source

Complete genome sequence of Clostridioides difficile NCTC 12727, a PCR ribotype 001 reference strain

We report the complete genome sequence of the PCR ribotype 001 Clostridioides difficile strain NCTC 12727 obtained by hybrid genome assembly, manual curation, and PCR validation.
Michael Macey, Terry Bilverstone, Ernesto Abel-Santos, Uzaira Saniah, Ilias Kounatidis, Rachel McMullan, Samiksha Venkatesan, Bilverstone, Terry, Macey, Michael, Abel-Santos, Ernesto, McMullan, Rachel, Venkatesan, Samiksha, Kounatidis, Ilias, Saniah, Uzaira   +13 more
core   +1 more source

Structural and functional insight into the interaction of Clostridioides difficile toxin B and FZD7

Cell Reports
Summary: The G protein-coupled receptors of the Frizzled (FZD) family, in particular FZD1,2,7, are receptors that are exploited by Clostridioides difficile toxin B (TcdB), the major virulence factor responsible for pathogenesis associated with ...
Julia Kinsolving, Julien Bous, Pawel Kozielewicz, Sara Košenina, Rawan Shekhani, Lukas Grätz, Geoffrey Masuyer, Yuankai Wang, Pål Stenmark, Min Dong, Gunnar Schulte   +10 more
doaj   +1 more source

Retrospective Study of the Epidemiology of Clostridioides difficile Infection in the Neurosurgery Department of a Tertiary Hospital in China

Infection and Drug Resistance, 2023
Xiajing Bi,1 Lisi Zheng,2 Zhi Yang,1 Tao Lv,2 Xiaofei Tong,1 Yunbo Chen2,3 1Department of Neurosurgery, The First Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou, People’s Republic of China; 2State Key Laboratory for Diagnosis and ...
Bi X, Zheng L, Yang Z, Lv T, Tong X, Chen Y   +5 more
doaj  

Immunometabolic Modulation by Low‐Dose Sodium Butyrate: PI3K/Akt/mTOR Signalling Orchestrates Macrophage Polarization to Protect Against Clostridioides difficile Colitis

Immunology, EarlyView.
Clostridioides difficile toxins TcdA and TcdB enter intestinal epithelial cells (IECs) via specific receptors, disrupt tight‐junction integrity and activate PI3K/Akt/mTOR signalling, promoting inflammasome assembly and IL‐1β release. Toxin‐induced IEC apoptosis further weakens the epithelial barrier.
Sisi Zhang, Zhou Jingxiang, Caixia Tan, Yuanyuan Xiao, Ju Zou, Biyue Tian, Anhua Wu, Chunhui Li   +7 more
wiley   +1 more source

Targeted restoration of the intestinal microbiota with a simple, defined bacteriotherapy resolves relapsing Clostridium difficile disease in mice. [PDF]

, 2012
Relapsing C. difficile disease in humans is linked to a pathological imbalance within the intestinal microbiota, termed dysbiosis, which remains poorly understood. We show that mice infected with epidemic C.
Parkhill Julian, Duncan Sylvia H., Deakin, Laura J., Thomas R. Connor (125272), Schreiber Fernanda, Brandt, Cordelia, Pickard Derek J., Flint, Harry J, Harry J. Flint (125298), Parkhill, J, Flint, Harry James, Trevor D. Lawley (125265), Simon Clare, Roland Rad (125284), David Goulding (125280), Julian Parkhill (30393), Claire Raisen (125275), Schreiber, F, Clare Simon, Taane G Clark, Deakin Laura J., Connor Thomas R., Taane G. Clark (106263), Clark, Taane G., Gordon Dougan, Duncan, SH, Sylvia H. Duncan (125296), Stares, Mark D., Raisen Claire, Roland Rad, Trevor D Lawley, Rad, Roland, Derek J. Pickard (125293), Sylvia H Duncan, Walker Alan W., Harry J Flint, Goulding David, Rad, R, Derek J Pickard, Deakin, LJ, Schreiber, Fernanda, Clark, Taane G, Clark, TG, Rad Roland, Walker, Alan W, Flint Harry J., Goulding, David, Alan W. Walker (50247), Raisen, C, Stares, MD, Pickard, Derek J, Flint, Harry J., Lawley, Trevor D, Deakin, Laura J, Connor, Thomas R, Claire Raisen, Brandt, C, Walker, AW, Mark D Stares, Walker, Alan W., Duncan, Sylvia H, Dougan Gordon, Connor, Thomas Richard, Clare, Simon, Pickard, Derek J., Laura J Deakin, Fernanda Schreiber, Fernanda Schreiber (85280), Lawley, TD, Clare, S, Julian Parkhill, Alan W Walker, David Goulding, Lawley, Trevor D., Raisen, Claire, Mark D. Stares (125271), Cordelia Brandt (125287), Laura J. Deakin (125290), Brandt Cordelia, Dougan, Gordon, Pickard, DJ, Duncan, Sylvia H., Parkhill, Julian, Simon Clare (125268), Clark Taane G., Flint, HJ, Gordon Dougan (30395), Thomas R Connor, Stares Mark D., Stares, Mark D, Goulding, D, Cordelia Brandt, Connor, TR, Dougan, G, Lawley Trevor D.   +94 more
core   +1 more source

Evaluation of Clinical Practice Guidelines on Fecal Microbiota Transplantation in Adults: A Cross‐Sectional Study

Journal of Evidence-Based Medicine, EarlyView.
ABSTRACT Objective Fecal microbiota transplantation (FMT) is an emerging multi‐disease therapy, yet the quality and consistency of its available clinical practice guidelines (CPGs) remain unknown. This study aimed to systematically evaluate the quality, content coverage and recommendation consistency of FMT‐related guidelines and develop an ...
Mingjuan Zhao, Shaojie Li, Guang Fu, Tong Deng, Yinghui Jin, Yingjiang Ye, Zhiqiang Li   +6 more
wiley   +1 more source

The Oral‐Gut Axis: Bidirectional Interactions Between Microbiome and Diseases

Journal of Periodontal Research, EarlyView.
This study aims to summarize the mechanisms underlying ectopic colonization of the gut by oral pathobionts and the microbial and host factors that regulate this process. ABSTRACT Increased colonization of typically oral microorganisms is frequently observed in the gut mucosa or lumen of individuals with gastrointestinal disorders, including patients ...
Shinya Ebihara, Nobuhiko Kamada
wiley   +1 more source