Results 171 to 180 of about 54,164 (265)

A randomized, double-blind, phase 3 safety and efficacy study of ridinilazole versus vancomycin for treatment of Clostridioides difficile infection: Clinical outcomes with microbiome and metabolome correlates of response [PDF]

BACKGROUND: Exposure to antibiotics predisposes to dysbiosis and Clostridioides difficile infection (CDI) that can be severe, recurrent (rCDI), and life-threatening.
Dubberke, Erik R, et al.,, Okhuysen, Pablo C   +2 more
core   +2 more sources

Understanding host immune responses in Clostridioides difficile infection: Implications for pathogenesis and immunotherapy

iMeta
Clostridioides difficile (C. difficile) is the predominant causative agent of nosocomial diarrhea worldwide. Infection with C. difficile occurs due to the secretion of large glycosylating toxin proteins, which can lead to toxic megacolon or mortality in ...
Lamei Wang, Javier A Villafuerte Gálvez, Christina Lee, Shengru Wu, Ciar n P. Kelly, Xinhua Chen, Yangchun Cao   +6 more
semanticscholar   +1 more source

Toxigenic profiles of clinical Clostridioides difficile in public and private healthcare settings in Gauteng, South Africa

International Journal of Infectious Diseases
Introduction: Clostridioides difficile infection (CDI) is a serious healthcare-associated infection causing life-threatening infectious diarrhea in hospitalized patients accounting for 20% to 30% of all diarrhoea cases in humans. Clostridioides difficile'
Dr Ben Prinsloo, Miss Hlambani Shirinda, Prof Anthony Smith, Prof Marthie Ehlers   +3 more
doaj   +1 more source

Microbiota Restoration Therapies for Recurrent Clostridioides difficile Infection Reach an Important New Milestone [PDF]

Microbiota restoration therapy has become a standard treatment for recurrent Clostridioides difficile infection (rCDI). In this article, we review the studies supporting the licensure of two live biotherapeutic products (LBPs) designed to prevent rCDI ...
DuPont, Andrew W, DuPont, Herbert L, Tillotson, Glenn S   +2 more
core   +1 more source

Evaluation of cases of Clostridioides difficile detected in a tertiary hospital in western Paraná state, Brazil. [PDF]

Background: Clostridioides difficile is an obligate anaerobic, gram-positive bacillus, with subterminal spores. It is also a producer of enterotoxins. Prolonged use of broad-spectrum antimicrobials in immunocompromised patients is often related to the ...
Ayres Torres Takaes, Rodrigo, Martini, Rhamon Antonio, Mello da Rosa Gioppo, Nereida, Paes Chagas, Artur, Suldofski, Monica Tereza   +4 more
core   +1 more source

Comparison of Patient Outcomes in a Pharmacist-Led Parenteral Antimicrobial Therapy Program [PDF]

, 2020
Howe, Zachary W., McCann, Jennifer, Saum, Lindsay   +2 more
core   +1 more source

Patient Education: Clostridioides difficile Infection

Journal of Gastrointestinal Infections, 2022
Ryan Pardi, Sahil Khanna
openaire   +1 more source

SHEA neonatal intensive care unit (NICU) white paper series: Practical approaches to Clostridioides difficile prevention [PDF]

, 2018
Bartlett, Allison H, Bryant, Kristina K, Cantey, Joseph B, Elward, Alexis M, Sandora, Thomas J, Yokoe, Deborah S   +5 more
core   +1 more source

In silico interaction of catalytic domain of Clostridioides difficile toxins TcdA and TcdB with some selected compounds from the SuperNatural 3.0 database

Kuwait Journal of Science
Clostridioides difficile is a pathogenic bacterium responsible for antibiotic-associated diarrhea globally. The pathogenesis of this bacterium is due to its virulence toxins, which inactivate the small GTPases from the Rho and Ras families in host cells,
doaj   +1 more source

When not to start antibiotics : avoiding antibiotic overuse in the intensive care unit

, 2020
De Waele, Jan, Denny, Kerina J, Harris, Patrick NA, Laupland, Kevin B, Lipman, Jeffrey   +4 more
core   +1 more source