Results 151 to 160 of about 54,164 (265)

Natural Products as the Modulators of Gut Microbiota: A Pool for the Development of New Treatment Against Obesity?

Food Frontiers, Volume 7, Issue 3, May 2026.
Natural compounds regulate gut microbiota by improving microbial balance and increasing probiotics, which boost short‐chain fatty acid production to alleviate insulin resistance and inflammation. Additionally, they stimulate appetite‐suppressing hormones through bile acid signaling, while inhibiting pathogenic bacteria to repair intestinal barrier ...
Hongchao Yuan, Yau‐Yuen Chan, Guang Chen, Lin Xu, Cheng Zhang, Guoyi Tang, Yibin Feng, Ning Wang   +7 more
wiley   +1 more source

Influence of Antibiotic Exposure Intensity on the Risk of Clostridioides difficile Infection.

Clinical Infectious Diseases
BACKGROUND Antibiotics are a strong risk factor for Clostridioides difficile infection (CDI), and CDI incidence is often measured as an important outcome metric for antimicrobial stewardship interventions aiming to reduce antibiotic use. However, risk of
Michael J. Ray, Luke C. Strnad, Kendall J. Tucker, Jon P. Furuno, Eric Lofgren, Caitlin M. McCracken, Hiromichi S. Park, Jeffrey S. Gerber, Jessina C. McGregor   +8 more
semanticscholar   +1 more source

Environmental Enrofloxacin Exposure as a Modifiable Driver of Mitochondria‐Mediated Intestinal Aging and Barrier Dysfunction

Aging Cell, Volume 25, Issue 5, May 2026.
Environmentally relevant enrofloxacin accelerates intestinal aging by impairing epithelial mitochondrial function, disrupting barrier integrity, and reshaping the gut microbiota. Mitochondrial restoration with pyrroloquinoline quinone alleviates hypoxia, inflammation, and gut damage.
Kan Yu, Nengzheng Wang, Xinyi Huang, Yushu Qiu, Xuejian He, Xiaofeng Zhu, Xiaolan Zhou, Peng Yu, Gang Wei, Yan Pi, Ting Ni   +10 more
wiley   +1 more source

Exploring the Toxin-Mediated Mechanisms in Clostridioides difficile Infection

Microorganisms
Clostridioides difficile infection (CDI) is the leading cause of nosocomial antibiotic-associated diarrhea, and colitis, with increasing incidence and healthcare costs. Its pathogenesis is primarily driven by toxins produced by the bacterium C. difficile,
Evdokia Pourliotopoulou, T. Karampatakis, Melania Kachrimanidou   +2 more
semanticscholar   +1 more source

CSPG4 Mediates Inflammatory, Cell Death, and Senescence Responses in Enteric Glia Exposed to Clostridioides difficile Toxins

The FASEB Journal, Volume 40, Issue 8, 30 April 2026.
Enteric glia in humans, mice, and rats express all known receptors for TcdA (LDLR) and TcdB (CSPG4, FZD‐1, FZD2, FZD7, PVRL3, TFPI, LRP1). CSPG4 expression is increased in colonic tissues from humans and mice with C. difficile infection, as well as in rat enteric glia exposed to TcdA or TcdB. C.
Francisco M. S. Marques, Deiziane V. S. Costa, Conceição S. M. Rebouças, Gerly A. C. Brito, Cirle A. Warren, Renata F. C. Leitão   +5 more
wiley   +1 more source

Structural and functional insight into the interaction of Clostridioides difficile toxin B and FZD7

Cell Reports
Summary: The G protein-coupled receptors of the Frizzled (FZD) family, in particular FZD1,2,7, are receptors that are exploited by Clostridioides difficile toxin B (TcdB), the major virulence factor responsible for pathogenesis associated with ...
Julia Kinsolving, Julien Bous, Pawel Kozielewicz, Sara Košenina, Rawan Shekhani, Lukas Grätz, Geoffrey Masuyer, Yuankai Wang, Pål Stenmark, Min Dong, Gunnar Schulte   +10 more
doaj   +1 more source

The presence of Clostridioides difficile in faeces before and after faecal microbiota transplantation and its relation with recurrent C. difficile infection and the gut microbiota in a Dutch cohort [PDF]

Objectives: The objectives of this study are to investigate the presence of Clostridioides difficile in faeces of patients with recurrent C. difficile infection (rCDI) before and after faecal microbiota transplantation (FMT) and to identify risk factors ...
, Berssenbrugge, Eric K L, Ducarmon, Quinten R, Goorhuis, Abraham, Groenewegen, Bas, Keller, Josbert J, Kovynev, Artemiy, Kuijper, Ed J, Sanders, Ingrid M J G, Smits, Wiep Klaas, Terveer, Elisabeth M, van den Berg, Alexander J, van Lingen, Emilie, van Nood, Els, van Prehn, Joffrey, Wiese, Maria   +15 more
core   +1 more source

Metagenomic, metabolomic, and lipidomic shifts associated with fecal microbiota transplantation for recurrent Clostridioides difficile infection

Msphere
Recurrent C. difficile infection (rCDI) is an urgent public health threat, for which the last resort and lifesaving treatment is a fecal microbiota transplant (FMT).
Arthur S. McMillan, Guozhi Zhang, Michael K. Dougherty, Sarah K McGill, A. S. Gulati, E. Baker, C. Theriot   +6 more
semanticscholar   +1 more source

Defining a Non‐Inferiority Margin for Delirium Resolution in a Clinical Trial of Older Adults With Bacteriuria and Abnormal Urine Tests

Journal of the American Geriatrics Society, EarlyView.
Orly Bogler, Michael Fralick, Christopher Kandel, Nathan M. Stall, Gajeni Prabaharan, Emil Hodzic‐Santor, Edward R. Marcantonio, Christina Reppas‐Rindlisbacher   +7 more
wiley   +1 more source

Management of Clostridioides difficile infection: an Italian Delphi consensus [PDF]

Background: Clostridioides difficile infection (CDI), a leading cause of nosocomial deaths, is a microbiota-mediated disease. As such, the use of broader spectrum antibiotics, such as vancomycin and metronidazole, can prime the gastrointestinal tract to ...
Armuzzi, Alessandro, Bassetti, Matteo, Caprioli, Flavio, Cascio, Antonio, De Rosa, Francesco Giuseppe, Dentali, Francesco, Meschiari, Marianna, Pani, Marcello, Parrella, Roberto, Petrosillo, Nicola, Pilotto, Alberto, Restelli, Umberto, Sanguinetti, Maurizio   +12 more
core   +2 more sources