Results 131 to 140 of about 54,164 (265)

Gut Microbiota–Gut Metabolites and Clostridioides difficile Infection: Approaching Sustainable Solutions for Therapy

Metabolites
Clostridioides difficile (C. difficile) infection (CDI) is the most common hospital-acquired infection. With the combination of a high rate of antibiotic resistance and recurrence, it has proven to be a debilitating public health threat.
Bijay Gurung, Maranda Stricklin, Shaohua Wang   +2 more
semanticscholar   +1 more source

The Gut Microbiome as a Therapeutic Target in Alopecia Areata: Not Yet Part of the Patient Treatment Plan

International Journal of Dermatology, EarlyView.
ABSTRACT Interest in the gut microbiome as a therapeutic target for treating alopecia areata (AA) has grown considerably. However, existing evidence remains limited and inconsistent. Currently, there is insufficient evidence to recommend microbiome‐directed testing and therapies to patients with AA.
Eric McMullen, Deema Abdel Hafeez, Nikhil Pai, Laurence Mainville, Shireen Dumont, Narachai Julanon, Romy Shenderey, Grace Xiong, Shahnawaz Towheed, Jeffrey Donovan   +9 more
wiley   +1 more source

Decreases in Antimicrobial Use Associated With Multihospital Implementation of Electronic Antimicrobial Stewardship Tools. [PDF]

, 2020
BackgroundAntimicrobial stewards may benefit from comparative data to inform interventions that promote optimal inpatient antimicrobial use.MethodsAntimicrobial stewards from 8 geographically dispersed Veterans Affairs (VA) inpatient facilities ...
Butler, Jorie M, Chou, Ann F, Glassman, Peter A, Goetz, Matthew Bidwell, Graber, Christopher J, Jones, Makoto M, Madaras-Kelly, Karl, Samore, Matthew H, Weir, Charlene, Youn, Sarah Y, Zhang, Yue   +10 more
core   +1 more source

Rationalizing Proton Pump Inhibitor Use: Southeast Asia Consensus Recommendations

Journal of Gastroenterology and Hepatology, EarlyView.
ABSTRACT Background and Aim Proton pump inhibitors (PPIs) are integral to managing many gastrointestinal conditions. However, the prevalent inappropriate PPI prescription across Southeast Asia (SEA) is concerning. Given the absence of locally tailored recommendations to inform clinical practice, this consensus document aims to provide recommendations ...
Somchai Leelakusolvong, Tju Siang Chua, Duc Trong Quach, Andrew Ming‐Liang Ong, Ari Fahrial Syam, Augusto Jose G. Galang, Wee Kooi Cheah, Hang Viet Dao, Jose D. Sollano, Kalwinder Singh Khaira, Phuripong Kijdamrongthum, Rahela Ambaras Khan, Sakkarin Chirapongsathorn, Yeong Yeh Lee   +13 more
wiley   +1 more source

A Comparison of Currently Available and Investigational Fecal Microbiota Transplant Products for Recurrent Clostridioides difficile Infection

Antibiotics
Clostridioides difficile infection (CDI) is an intestinal infection that causes morbidity and mortality and places significant burden and cost on the healthcare system, especially in recurrent cases.
Yifan Wang, Aaron Hunt, Larry H. Danziger, E. Drwiega   +3 more
semanticscholar   +1 more source

Mechanisms of Clostridioides difficile glucosyltransferase toxins and their roles in pathology: insights and emerging therapeutic strategies

Frontiers in Cellular and Infection Microbiology
Clostridioides difficile infection (CDI) is a significant cause of antibiotic-associated diarrhea and pseudomembranous colitis, manifesting as mild diarrhea, fulminant colitis, and even death.
Xin Wen, Xue Liu, Kai Wan, Hong Liu, Cheng Zhang, Xi Zhang, Qin Wen   +6 more
doaj   +1 more source

Identification of Biosynthetic Inhibitors of Virulence Factor Entry Into Mammalian Cells [PDF]

, 2023
Clostridioides difficile toxin B (TcdB) and the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) are the primary virulence factors behind the C.
Icho, Simoun
core   +1 more source

Microbial bile salt hydrolases mediate the efficacy of faecal microbiota transplant in the treatment of recurrent Clostridioides difficile infection

Gut, 2019
Objective Faecal microbiota transplant (FMT) effectively treats recurrent Clostridioides difficile infection (rCDI), but its mechanisms of action remain poorly defined. Certain bile acids affect C. difficile germination or vegetative growth.
B. Mullish, J. McDonald, A. Pechlivanis, J. Allegretti, D. Kao, Grace F. Barker, D. Kapila, E. Petrof, S. Joyce, C. Gahan, Izabela Glegola-Madejska, H. Williams, E. Holmes, Thomas B. Clarke, M. Thursz, J. Marchesi   +15 more
semanticscholar   +1 more source

Clinical benefit of faecal microbiota transplantation administered via a single retention enema as an adjunctive treatment in dogs with chronic enteropathy: a randomised controlled trial

Journal of Small Animal Practice, EarlyView.
Objectives To evaluate the clinical benefit of faecal microbiota transplantation administered via a single retention enema, as an adjunctive treatment in the management of dogs with chronic enteropathy. Materials and Methods Blinded, randomised controlled trial.
F. Allerton, M. J. Whittle, L. Durkin, C. Prior, M. Trehy, H. Swales, F. Duplan, S. Borgonovi, G. Pinchbeck, I. Gajanayake, M. Dunning, T. Sparks, P. Watson, G. C. A. Amos, K. McCallum, J. Bazelle, A. Kent   +16 more
wiley   +1 more source

Clostridioides difficile Enteritis Induced Anastomotic Rupture: A Case Report and Literature Review

Case Reports in Surgery, 2020
Background. A 76-year-old male patient who suffered small bowel anastomotic dehiscence believed to be a complication provoked by Clostridioides difficile enteritis. Case Presentation. The patient was a 76-year-old male who underwent small bowel resection
David R. Velez, Mentor Ahmeti
doaj   +1 more source