Results 141 to 150 of about 20,312 (245)

A Single Amino Acid Substitution in CspA Increases Germination Sensitivity and Broadens Bile Salt Germinant Specificity in Clostridioides difficile Spores

Environmental Microbiology, Volume 28, Issue 6, June 2026.
In reservoir‐associated RT033 strains, we observe a natural rewiring of spore germination that lowers the activation threshold and broadens bile‐salt specificity, enabling germination at low germinant levels and in response to typically inhibitory bile‐salts common in animal hosts.
Isabel Roseiro, Alexandra Nunes, Diogo Martins, Frederico Alves, Søren Persson, Adriano O. Henriques, Mónica Oleastro, Mónica Serrano   +7 more
wiley   +1 more source

A Refined Method for Fecal Microbiota Transplantation Using Nutella

Clinical and Translational Science, Volume 19, Issue 6, June 2026.
ABSTRACT Fecal microbiota transplantation (FMT) in mice is an evolving research field, often employing oral gavage, which can be stressful and harmful for the animals and time‐consuming for technicians. Voluntary intake methods, such as delivery in Nutella, have successfully been used for drug administration in mice and may likewise be a promising tool
Ida W. Henriksen, Camilla H. F. Hansen, Janne Koch, Dorte B. Sørensen, Dennis S. Nielsen, Christina Bartholdy, Axel K. Hansen   +6 more
wiley   +1 more source

Altitude‐Associated Divergence of the Gut Microbiome in Endangered Forest Musk Deer: Evidence From Integrated Metagenomics, Metabolomics, and Culturomics

Evolutionary Applications, Volume 19, Issue 6, June 2026.
ABSTRACT High‐altitude environments expose mammals and their gut symbionts to multifaceted stressors—hypoxia, cold, and intense UV radiation. Whether gut microbial communities undergo compositional restructuring in response to these stressors, and whether such restructuring carries translational value for captive conservation, remain unresolved ...
Feiyun Huang, Zexiu Zhang, Yanni Zhao, Sen Ye, Maoyuan Gan, Xuxin Li, Yele Zhang, Lei Chen, Yushuo Zhang, Lingxi Chen, Ting Wang, Jinming Huang, Xiuyue Zhang   +12 more
wiley   +1 more source

Antimicrobial Resistance of Clostridioides difficile in Children from a Tertiary Pediatric Hospital in Shanghai, China

Xiaolu Li,1,* Yizhong Wang,1,2,* Rong Cao,1 Fangfei Xiao,1 Xufei Wang,1 Lin Ye,1 Yongmei Xiao,1 Dan Li,1 Ting Zhang1,2 1Department of Gastroenterology, Hepatology and Nutrition, Shanghai Children’s Hospital, School of Medicine, Shanghai Jiao Tong
Li X, Ye L, Zhang T, Li D, Xiao Y, Xiao F, Wang X, Wang Y, Cao R   +8 more
core  

Rationalizing Proton Pump Inhibitor Use: Southeast Asia Consensus Recommendations

Journal of Gastroenterology and Hepatology, Volume 41, Issue 6, Page 1685-1700, June 2026.
ABSTRACT Background and Aim Proton pump inhibitors (PPIs) are integral to managing many gastrointestinal conditions. However, the prevalent inappropriate PPI prescription across Southeast Asia (SEA) is concerning. Given the absence of locally tailored recommendations to inform clinical practice, this consensus document aims to provide recommendations ...
Somchai Leelakusolvong, Tju Siang Chua, Duc Trong Quach, Andrew Ming‐Liang Ong, Ari Fahrial Syam, Augusto Jose G. Galang, Wee Kooi Cheah, Hang Viet Dao, Jose D. Sollano, Kalwinder Singh Khaira, Phuripong Kijdamrongthum, Rahela Ambaras Khan, Sakkarin Chirapongsathorn, Yeong Yeh Lee   +13 more
wiley   +1 more source

A Parallel Regulatory Pathway for New Microbial Technologies in China: Distinct From Drugs and Devices

Microbiota Medicine Research, Volume 1, Issue 2, Page 37-40, June 2026.
Rui Wang, Pan Li, Chen Lu, Faming Zhang
wiley   +1 more source

Development and Application of a Novel Dose–Response Model for the Quantification of Clostridioides difficile Infection Risks

Risk Analysis, Volume 46, Issue 6, June 2026.
ABSTRACT The lack of a dose–response model for Clostridioides difficile, attributed to insufficient human data, challenges effective C. difficile infection (CDI) risk management. This study presents a novel murine‐derived dose–response model for C.
Elizabeth N. Paddy, M. Sohail, Oluwasola O. D. Afolabi   +2 more
wiley   +1 more source

From Mask to Bed: Protective Barrier Containment and Rethinking the Prevention of Pathogen Transmission

Microbiota Medicine Research, Volume 1, Issue 2, Page 41-44, June 2026.
Quan Wen, Sheng Zhang, Qian Wang, Yuan Wu, Wei Hong, Juan Liao, Hon Ho Yu, Furu Wang, Yongzhan Nie, Faming Zhang   +9 more
wiley   +1 more source

Meta-analysis of predictors of healthcare-associated Clostridioides difficile infection

Our systematic review and meta-analysis of 40 studies (n = 3,905,559) identified gastric acid suppressants, recent hospitalization, antibiotic exposure, and certain comorbidities as independent predictors of healthcare-associated Clostridioides difficile
William M. Patterson, Neil Nero, Jesse Fajnzylber, Adrian V. Hernandez, Abhishek Deshpande   +4 more
core   +1 more source

In silico interaction of catalytic domain of Clostridioides difficile toxins TcdA and TcdB with some selected compounds from the SuperNatural 3.0 database

Kuwait Journal of Science
Clostridioides difficile is a pathogenic bacterium responsible for antibiotic-associated diarrhea globally. The pathogenesis of this bacterium is due to its virulence toxins, which inactivate the small GTPases from the Rho and Ras families in host cells,
doaj   +1 more source