Results 111 to 120 of about 32,022 (272)

Structural Insights into Rational Design of Single-Domain Antibody-Based Antitoxins against Botulinum Neurotoxins. [PDF]

, 2020
Botulinum neurotoxin (BoNT) is one of the most acutely lethal toxins known to humans, and effective treatment for BoNT intoxication is urgently needed. Single-domain antibodies (VHH) have been examined as a countermeasure for BoNT because of their high ...
Jin, Rongsheng, Lam, Kwok-Ho, McNutt, Patrick M, Ondeck, Celinia, Perry, Kay, Shoemaker, Charles B, Tremblay, Jacqueline M, Vazquez-Cintron, Edwin, Webb, Robert P   +8 more
core  

Noradrenaline release from permeabilized synaptosomes is inhibited by the light chain of tetanus toxin [PDF]

, 1992
Noradrenaline release from rat brain cortical synaptosomes permeabilized with streptolysin O can be triggered by μM concentrations of free Ca2+. This process was inhibited within minutes by tetanus toxin and its isolated light chain, but not by its heavy
Ahnert-Hilger, Ahnert-Hilger, Bittner, Bittner, Bittner, Bradford, Brigitte Stecher, Dayanithi, Dayanithi, De, Dekker, Dekker, Dunkley, Eisel, Föhr, Habermann, Hens, Jacques J.H. Hens, Kistner, Maisey, Manfred Gratzl, Matsuda, McInnes, Mochida, Mochida, Penner, Pierre N.E. De Graan, Poulain, Simpson, Stecher, Stecher, Stecher, Ulrich Weller, Weller, Weller, Willem-Hendrik Gispen   +35 more
core   +2 more sources

A Drosophila Model for Clostridium difficile Toxin CDT Reveals Interactions with Multiple Effector Pathways. [PDF]

, 2020
Clostridium difficile infections (CDIs) cause severe and occasionally life-threatening diarrhea. Hyper-virulent strains produce CDT, a toxin that ADP-ribosylates actin monomers and inhibits actin polymerization.
Bier, Ethan, Franc, Nathalie C, Guichard, Annabel, Roy, Sitara, Schwartz, Ruth   +4 more
core  

The orphan germinant receptor protein GerXAO (but not GerX3b) is essential for L-alanine induced germination in Clostridium botulinum Group II [PDF]

, 2018
Clostridium botulinum is an anaerobic spore forming bacterium that produces the potent botulinum neurotoxin that causes a severe and fatal neuro-paralytic disease of humans and animals (botulism). C.
A Marchler-Bauer, AJ Page, AT Carter, AT Carter, BH Raphael, C Clauwers, C Mazuet, C Mazuet, CA Meaney, CH Williamson, D Bhattacharjee, D Leclair, D Paredes-Sabja, D Paredes-Sabja, D Paredes-Sabja, D Purdy, E Wachnicka, F Sievers, G Christie, G Christie, G Christie, GR Cooper, J Brunt, J Brunt, J Brunt, J Brunt, J Li, J Perutka, J Plowman, JT Heap, JT Heap, K Tamura, KA Weedmark, KD Hudson, KK Griffiths, KK Hill, KK Hill, M Paidhungat, M Paidhungat, M Sebaihia, MB Francis, MR Weigand, MW Peck, MW Peck, MW Peck, MW Peck, MW Peck, MW Peck, P Setlow, P Setlow, S Banawas, S Hielm, S Wang, S Wang, S Zhang, S Zhang, SC Stringer, T Seemann, V Broussolle, Y Xiao   +59 more
core   +1 more source

Clostridium botulinum strain Af84 contains three neurotoxin gene clusters: bont/A2, bont/F4 and bont/F5.

PLoS ONE, 2013
Sanger and shotgun sequencing of Clostridium botulinum strain Af84 type Af and its botulinum neurotoxin gene (bont) clusters identified the presence of three bont gene clusters rather than the expected two. The three toxin gene clusters consisted of bont
Nir Dover, Jason R Barash, Karen K Hill, Karen W Davenport, Hazuki Teshima, Gary Xie, Stephen S Arnon   +6 more
doaj   +1 more source

Some simple rules for estimating reproduction numbers in the presence of reservoir exposure or imported cases [PDF]

arXiv, 2018
The basic reproduction number ($R_0$) is a threshold parameter for disease extinction or survival in isolated populations. However no human population is fully isolated from other human or animal populations. We use compartmental models to derive simple rules for the basic reproduction number for populations with local person-to-person transmission and
arxiv  

Botulismo tipo C em ganso ocorrido em Minas Gerais, Brasil Type C botulism in a goose at Minas Gerais, Brazil

Ciência Rural, 2008
Botulismo é uma intoxicação causada pela ingestão das toxinas produzidas pelo Clostridium botulinum, que acomete mamíferos e aves, caracterizando-se por um quadro de paralisia flácida. Neste trabalho, é descrito um caso de botulismo em ganso, ocorrido no
Francisco Carlos Faria Lobato, Felipe Masiero Salvarani, Rodrigo Otávio Silveira Silva, Nelson Rodrigo Souza Martins, Andréa Márcia de Souza, Maurício Baltazar de Carvalho Filho, Ricardo Aurélio Pinto Nascimento, Ronnie Antunes de Assis   +7 more
doaj   +1 more source

A Targeted Therapeutic Rescues Botulinum Toxin-A Poisoned Neurons [PDF]

, 2008
Botulinum neurotoxin (BoNT), a Category A biothreat agent, is the most potent poison known to mankind. Currently no antidote is available to rescue poisoned synapses.
Bal Ram Singh, Dan Li, James Keller, Michael Adler, Peng Zhang, Prabhati Ray, Radharaman Ray   +6 more
core   +1 more source

Botulinum Toxin [PDF]

, 2009
Botulinum toxin is a neurotoxic protein produced by the bacterium Clostridium botulinum. Although botulinum toxin is the cause of the disease botulism and can be used in a terrorist attack, there are also many other uses for botulinum toxin.
Moshayev, David
core   +1 more source

Inhibition of Clostridium botulinum and Molds in Aged, Surface Ripened Cheese [PDF]

, 1959
N. Grecz, R.O. Wagenaar, G. M. Dack
openalex   +1 more source