Results 111 to 120 of about 34,415 (160)

Extended High‐Dose Tofacitinib Induction Improves Clinical Response in Ulcerative Colitis: A Multicenter Cohort Study

JGH Open, Volume 10, Issue 5, May 2026.
ABSTRACT Background and Aims Tofacitinib, an oral Janus Kinase (JAK) inhibitor, has demonstrated efficacy for ulcerative colitis (UC) in clinical trials, but the optimal dosing regimen remains unclear. This study aims to assess the effectiveness and safety of tofacitinib for UC in a real‐world Australian cohort focusing on outcomes of standard 8‐week ...
R. Gilmore, T. Pham, R. G. Fernandes, S. Lo, E. K. Wright, O. Rosella, P. De Cruz, B. Andrew, A. Vasudevan, K. Gazelakis, G. T. Moore, L. Thin, K. Au, S. Ghaly, C. Chen, W. Mohsen, T. Goodwin, M. P. Sparrow, M. G. Ward, M. Chew, M. Garg, E. Shelton, I. C. Lawrance, A. Thorat, C. da Fonseca Pereira, J. Begun, Y. K. An   +26 more
wiley   +1 more source

Outcomes of Clostridium difficile Infection in Patients With Idiopathic Pulmonary Fibrosis: Analysis of the Nationwide Inpatient Sample, 2016–2020

JGH Open, Volume 10, Issue 5, May 2026.
ABSTRACT Background Idiopathic pulmonary fibrosis (IPF) is a progressive lung disease with poor prognosis. Patients with IPF are frequently exposed to risk factors for Clostridium difficile infection (CDI), such as advanced age, antibiotic use, and gastric acid suppression.
Chun Ho Szeto, Gloria Erazo Montalvan, Chung Yin Tai, Edgar Luna Landa, Godfrey Tabowei, Raymond Wadie, Raghavendra Sanivarapu   +6 more
wiley   +1 more source

Unraveling the Transmission Dynamics of a Novel Norovirus GII.17[P17] Lineage During Two Consecutive Outbreaks in a Spanish Hospital

Journal of Medical Virology, Volume 98, Issue 5, May 2026.
ABSTRACT Norovirus outbreaks in healthcare settings pose significant challenges to infection prevention and control (IPC). To prevent and control such outbreaks efficiently, identifying sources and transmission clusters (TCs) is crucial but often limited by traditional outbreak investigations.
Jasmin S. Kutter, Oscar Cuevas‐Lobato, Blanca Esperanza Fernandez‐Pacheco‐Gonzalez‐Echavarri, Carolina Moreno‐Gomila, Nerea Garcia‐Ibañez, Juan Camacho, Estrella Ruiz‐Pedro, Maria Cabrerizo, Juan‐Ignacio Alós, Francisco Diez‐Fuertes, Maria Dolores Fernandez‐Garcia   +10 more
wiley   +1 more source

Effectiveness and safety of ustekinumab in pediatric Crohn's disease: Results of the REALITI study

Journal of Pediatric Gastroenterology and Nutrition, Volume 82, Issue 5, Page 1242-1250, May 2026.
Abstract Objectives Few approved treatments exist for children with Crohn's disease (CD). The REALITI study retrospectively assessed the effectiveness and safety of ustekinumab in real‐world clinical settings for children with CD. Methods Data were collected from the prospective ImproveCareNow (ICN) registry for pediatric patients (≥ 2 to <18 years old)
Steven J. Steiner, Jeremy Adler, Shehzad A. Saeed, Richard S. Strauss, Kristin M. Howe, Anna Sheahan, Renping Zhang, Kimberly R. Keihn, Katharine Harrow, Kelly K. Olano, David A. Evans, Kim Hung Lo, Nanhua Zhang, Lilianne Kim, Richard B. Colletti, Sheri Volger, for the ImproveCareNow Learning Health Network, Sabina Ali, Rana Ammoury, Keren L. Appel, Travis Ayers, Howard Baron, Julie Bass, Rachel Bensen, Erica J. Brenner, José Cabrera, Mallory Chavannes, J Fernando del Rosario, Jill Dorsey, Dana M. H. Dykes, Dawn R. Ebach, Bhaskar Gurram, Dyer Heintz, Leslie M. Higuchi, Edward J. Hoffenberg, Jeannie S. Huang, Esther Jacobowitz Israel, Traci W. Jester, Ian Kang, Ian Leibowitz, Tiffany Linville, Ross M. Maltz, Craig A. McKinney, Lybil B. Mendoza Alvarez, Phillip Minar, Tina Morhardt, Alisa J Muñiz Crim, Barbara Joanna Niklinska‐Schirtz, Daniel M. O'Connell, Helen Pappa, Brad Pasternak, Trusha Patel, Meryl K. Perlman, Kelly C. Sandberg, Marc E. Schaefer, Robbyn E. Sockolow, David L. Suskind, Gitit Tomer, Jeanne Tung, Amanda A. Wenzel, Denise D. Young   +60 more
wiley   +1 more source

Gastrointestinal manifestations following chimeric antigen receptor T‐cell (CAR‐T) 19 therapy in pediatric patients with CD19+ acute lymphoblastic leukemia

JPGN Reports, Volume 7, Issue 2, Page 377-381, May 2026.
Abstract Pediatric patients with CD19+ acute lymphoblastic leukemia (ALL) undergoing chimeric antigen receptor T‐cell (CAR‐T) therapy frequently experience gastrointestinal (GI) complications. A retrospective study analyzed 13 patients (median age: 8 years) treated between January 2020 and January 2024.
Judith Raya Muñoz, Melissa Panesso Romero, Saray Mesonero Cavia, Marta Freixas Bermejo, Vanessa Cabello Ruiz, Marina Álvarez Beltran, Maria Cristina Díaz de Heredia Rubio, Susana Elena Redecillas Ferreiro, Oscar Segarra Canton   +8 more
wiley   +1 more source

When protein losing enteropathy persists: A case series of viral and lymphatic‐associated etiologies

JPGN Reports, Volume 7, Issue 2, Page 227-230, May 2026.
Abstract Protein‐losing enteropathy (PLE) is a rare condition that is characterized by loss of plasma protein in the intestines leading to hypoproteinemia with subsequent peripheral edema and possibly anasarca. The pathophysiology of PLE varies depending on the etiology and involves either intestinal mucosal injury or lymphatic system alterations ...
Natalie Jennings, Antonia C. Rovira, Pamela Castillo Rocha, Janelle Torres, Claudia M. Salgado, Miguel Reyes‐Múgica, Richard N. Arboleda, Fatima S. Hussain   +7 more
wiley   +1 more source

Early Antibiotic Discontinuation for Children With a Positive Rapid Respiratory Viral Test Hospitalized for Suspected Bacterial Tracheostomy‐Associated Infections

Pediatric Pulmonology, Volume 61, Issue 5, May 2026.
ABSTRACT Objective Test the association between early antibiotic discontinuation and outcomes for children with a tracheostomy and positive respiratory viral PCR (RVP) hospitalized with suspected bTRAIN (bacterial TRacheostomy‐Associated INfection; pneumonia/tracheitis).
Christopher J. Russell, Naoko Kono, Margaret Rush, Andrea Hahn, Catherine S. Forster, Jonathan D. Cogen, Sarah Hofman DeYoung, John M. Morrison, Joanna Thomson, Sukhada Vaidya Mairal, Wendy J. Mack, Michael N. Neely, Tamara D. Simon, for the Pediatric Research in Inpatient Settings Network   +13 more
wiley   +1 more source

The scale matters: A review on stimuli‐responsive microrobots categorized by scale for biomedical applications

Responsive Materials, Volume 4, Issue 2, May 2026.
We systematically summarize how each scale dictates fundamental choices in design feature, manufacturing technology, driving mechanism, and control strategy, which are inherently governed by scale‐dominated physical principles. Furthermore, the application of scale‐determined operation modes of microrobots across different stages of medical ...
Hang Yin, Yujing Li, Guanghao Wu, Yubing Guo   +3 more
wiley   +1 more source

Herb‐Based Extracellular Vesicles for Infectious Disease

Small Structures, Volume 7, Issue 5, May 2026.
Chinese herbal medicine‐derived extracellular vesicles‐like particles (CHM‐EVLPs) are presented as innovative nanomedicines for infectious diseases. This review highlights their diverse therapeutic effects, including pathogen clearance, immune modulation, microbiota regulation and tissue barrier repairment, unlocking a powerful natural material against
Erjia Weng, Zhi‐Chao Sun, Yuntao Liu, Ran Liao, Ran Lin, Yan Zhang, Xi Zhang, Minghua Tang, Kaichun Yang, Xiaolu Wang, Wen Huang, Zhongde Zhang, Xiaotu Xi, Jun Wu   +13 more
wiley   +1 more source

Aged Gut Microbiota Induces Mucosal Transcriptional Dysregulation, Impairing Immune Surveillance

Aging Cell, Volume 25, Issue 5, May 2026.
Aging impaired intestinal mucosal immune homeostasis by altering the epithelial barrier, lamina propria immune cells, follicle‐associated epithelium, and gut microbiota. These changes, particularly the accumulation of pro‐inflammatory bacteria in the gut microbiota, are closely associated with dysregulation of follicle‐associated epithelium gene ...
Fang Wu, Ming Zhang, Jianmin Wu, Zihan Wang, Yumeng Ma, Lin Dong, Le Cheng, Tengteng Ji, Chenyan Zheng, Fazheng Ren, Bing Fang   +10 more
wiley   +1 more source