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Update on Clostridium difficile infection
Current Opinion in Gastroenterology, 2011This review summarizes the most recent epidemiological data and advances in research into the pathogenesis, diagnosis and treatment of Clostridium difficile infection (CDI).The epidemiology of CDI has changed with the emergence of hypervirulent strains.
Caoilfhionn, O'Donoghue, Lorraine, Kyne
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Clostridium difficile infection in Thailand
International Journal of Antimicrobial Agents, 2015Clostridium difficile is the aetiological agent in ca. 20% of cases of antimicrobial-associated diarrhoea in hospitalised adults. Diseases caused by this organism range from mild diarrhoea to occasional fatal pseudomembranous colitis. The epidemiology of C.
Papanin Putsathit +3 more
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Infection control: Clostridium Difficile
Nursing and Residential Care, 2007Clostridium difficile is a gram-positive, spore-forming bacteria that produces toxins when infection occurs. Infection can cause diarrhoea or life-threatening colitis ( Barbut et al, 2007 ). There has been an 85% reduction in hospital-acquired Clostridium difficile infections over the past eight years ( Public Health England, 2014 ).
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Clostridium difficile infection
BMJ, 2009Rangaiah and colleagues comment that currently used tests for Clostridium difficile toxin are not very sensitive.1 However, the specificity of these commercial assays also ranges from 97% to 99%, meaning that approximately 1-2 out of every 10 positive results using these kits are incorrect.2 False positive results are even more likely when testing ...
Mark H, Wilcox, Tim, Planche
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Treatment of clostridium difficile infection
Current Treatment Options in Gastroenterology, 2004With the introduction of broad-spectrum antibiotics into clinical practice, Clostridium difficile infection has become the most common cause of infectious diarrhea in hospitalized patients. Although mild cases may resolve by discontinuing antibiotics, thus allowing re-establishment of colonic microflora, oral metronidazole or vancomycin is indicated if
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Treatment of Clostridium difficile Infections
Infectious Disease Clinics of North America, 2015Vancomycin and metronidazole were historically considered equivalent therapies for the management of Clostridium difficile infections (CDI); however, recent data confirm more favorable outcomes with vancomycin. Fidaxomicin is a narrow spectrum antibiotic that has an advantage in reducing recurrence rates compared with vancomycin, possibly owing to its ...
Melinda M, Soriano, Stuart, Johnson
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Clostridium difficile Infection
Annual Review of Medicine, 1998Clostridium difficile infection is associated with broad-spectrum antibiotic therapy and is the most common cause of infectious diarrhea in hospital patients. Pathogenic strains of C. difficile produce two protein exotoxins, toxin A and toxin B, which cause colonic mucosal injury and inflammation. Infection may be asymptomatic, cause mild diarrhea, or
C P, Kelly, J T, LaMont
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Clostridium difficile Infections in Children
Pediatric Infectious Disease Journal, 2009Clostridium difficile, a spore-forming Grampositive bacillus, is a frequent cause of antibiotic-associated diarrhea and a common nosocomial pathogen. Clinical manifestations of disease range from self-limited diarrhea to life-threatening colitis and death. Historically, C.
Kristina, Bryant, L Clifford, McDonald
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Clostridium difficile Infection Is on the Rise
AJN, American Journal of Nursing, 2014The emergence of an epidemic strain makes prevention and early diagnosis critical.
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Clostridium difficile infection in diabetes
Diabetes Research and Clinical Practice, 2014Diabetes-related hospitalization and hospital utilization is a serious challenge to the health care system, a situation which may be further aggravated by nosocomial Clostridium difficile (C. difficile) infection (CDI). Studies have demonstrated that diabetes increases the risk of recurrent CDI with OR (95% CI) 2.99 (1.88, 4.76). C. difficile is a gram-
Hui-Qi, Qu, Zhi-Dong, Jiang
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