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Clostridium difficile infection in the elderly.

Le infezioni in medicina, 2013
The incidence of C. difficile infections (CDI) in the elderly continues to rise and infection is associated with increased morbidity and mortality when compared to those affected in younger age-groups. Immunosenescence may be a contributory factor yet the exact immune responses that may protect against CDI are incompletely understood.
Di Bella, Stefano, Capone, Alessandro, Musso, Maria, GIANNELLA, MADDALENA, Tarasi, Agapito, Johnson, Emma, Taglietti, Fabrizio, Campoli, Caterina, Petrosillo, Nicola   +8 more
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Emerging therapies for Clostridium difficile infection – focus on fidaxomicin

, 2013
Fredy Chaparro-Rojas, Kathleen M MullaneDepartment of Medicine, Section of Infectious Diseases, University of Chicago, Chicago, IL, USAAbstract: The epidemiology of Clostridium difficile infections (CDI) has evolved during the last decades, with an ...
Mullane KM, Chaparro-Rojas F
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Clin Infect Dis [PDF]

Nucleic acid amplification testing (NAAT) is increasingly being adopted for diagnosis of Clostridium difficile infection (CDI). Data from 3 states conducting population-based CDI surveillance showed increases ranging from 43% to 67% in CDI incidence ...

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Clostridium difficile infection: appendix [PDF]

Journal of Antimicrobial Chemotherapy, 1998
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Clostridium difficile infection [PDF]

Nature Reviews Disease Primers, 2016
Infection of the colon with the Gram-positive bacterium Clostridium difficile is potentially life threatening, especially in elderly people and in patients who have dysbiosis of the gut microbiota following antimicrobial drug exposure. C. difficile is the leading cause of health-care-associated infective diarrhoea. The life cycle of C.
Ed J Kuijper, Mark H. Wilcox, Wiep Klaas Smits   +2 more
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Clostridium difficile Infection

Infectious Disease Clinics of North America, 2017
Clostridium difficile infection is a major health care challenge in terms of patient and economic consequences. For the patient, it is a morbid and sometimes a life-threatening iatrogenic complication of antibiotic treatment. In the United States, the provider's institution may face financial penalties, because the Centers for Disease Control and ...
Luis, Alcalá Hernández, Elena, Reigadas Ramírez, Emilio, Bouza Santiago   +2 more
openaire   +4 more sources

Clostridium difficile Infection

Critical Reviews in Clinical Laboratory Sciences, 1996
The spore-forming anaerobe Clostridium difficile has become a serious enteropathogen. Changes in the composition of natural intestinal flora, mainly due to antibiotic therapy, permit its colonization of, and multiplication in, the colon. The disease is caused by (entero)toxin A and (cyto)toxin B, and infection ranges from asymptomatic carrier state and
Dieter H. M. Gröschel, B. Toye
openaire   +2 more sources

Clostridium difficileInfection

New England Journal of Medicine, 2015
This article reviews the pathogenesis, epidemiology, diagnosis, and treatment of this nosocomial and potentially fatal infectious diarrhea, as well as the associated risk factors. New treatments include fecal microbiota transplantation for disease that is resistant to vancomycin.
Sam K, Sharma, Kentaro, Nakajima, Parul J, Shukla   +2 more
openaire   +7 more sources

Clostridium difficile Infection in the Elderly

Clinics in Geriatric Medicine, 2014
Clostridium difficile-associated illness is an increasingly prevalent and morbid condition. The elderly population is at a disproportionate risk of developing symptomatic disease and associated complications, including progression to severe or fulminant disease, and development of recurrent infections. This article analyzes the factors that influence C
Jonathan M, Keller, Christina M, Surawicz   +1 more
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Update on Clostridium difficile infections

Médecine et Maladies Infectieuses, 2014
Clostridium difficile infections (CDI) occur primarily in hospitalized patients with risk factors such as concomitant or recent use of antibiotics. CDI related additional costs are important for the global population and health-care facilities. CDI epidemiology has changed since 2003: they became more frequent boosted by large outbreaks, more severe ...
Le Monnier, A., Zahar, J.-R., Barbut, F.
openaire   +3 more sources