Spatial metabolic and phenotypic characterization of the germ‐free mouse model
The germ‐free mouse model is a useful tool to understand the influence of the gut microbiota on host physiology. Using spatial metabolomics approaches we mapped the systemic location of small molecules in germ free and colonized mice, focusing on the intestine, spleen, lung, liver, and kidney.
Lauren Adams+8 more
wiley +1 more source
Comments on "Case report on Clostridium perfringens-induced gas gangrene following an intramuscular injection: A stark reminder of injection-associated risks". [PDF]
Ghezel A, Arfaee CS.
europepmc +1 more source
Leveraging chemical synthesis to discover metabolites from the gut microbiome
Metabolomics or the study of small molecule metabolism is used to identify compounds produced by the gut microbiota, but chemical annotation is a major bottleneck. Here, we review examples where organic synthesis was leveraged in traditional or next generation workflows to help identify new bioactive gut microbial metabolites.
Allison J. Keys+3 more
wiley +1 more source
Harnessing dual-channel probiotics to synergistically correct intestinal and vaginal dysbiosis after antibiotic disruption. [PDF]
Zhao X+9 more
europepmc +1 more source
The Genetic Blueprint of Obesity: From Pathogenesis to Novel Therapies
ABSTRACT Obesity is a chronic metabolic disease characterized by disturbances in energy homeostasis, leading to excessive fat accumulation. The pathogenesis of the disease is shaped by a complex interplay of genetic, epigenetic, biological, psychological, and environmental factors.
Gašper Tonin+6 more
wiley +1 more source
Prevalence of <i>Blastocystis</i> spp. and Other Gastrointestinal Pathogens Among Patients Admitted to Research Hospitals in Campania Region, Italy. [PDF]
Ascierto M+8 more
europepmc +1 more source
ABSTRACT Background Broad‐spectrum antibiotics are standard for febrile neutropenia (FN) in allogeneic hematopoietic stem cell transplantation (HSCT) but may disrupt gut microbiota, increasing the risk of graft‐versus‐host disease (GVHD). However, current evidence on the effects of anaerobic versus limited anaerobic antibiotic coverage on GVHD‐related
Hiroshi Ito+5 more
wiley +1 more source
Case report of clostridium difficile infection after rectal resection with ileostomy. [PDF]
Guo H, Jiang H, Liu H.
europepmc +1 more source
CLOSTRIDIUM DIFFICILE INFECTION IN KIDNEY OR LIVER GRAFT RECIPIENTS
Mariusz Niemczyk+5 more
openalex +1 more source