Results 41 to 50 of about 13,181 (300)

How do hospital professionals involved in a randomised controlled trial perceive the value of genotyping vs. PCR-ribotyping for control of hospital acquired C. difficile infections? [PDF]

, 2014
Background: Despite scientific advances in typing of C. difficile strains very little is known about how hospital staff use typing results during periods of increased incidence (PIIs). This qualitative study, undertaken alongside a randomised controlled
Peter M Hawkey, Hawkey, Peter M., Szczepura, Ala, Parsons, Helen, Katherine Hardy, Susan Manzoor, Gossain, Savita, Savita Gossain, Hardy, K. (Katherine), Stallard, Nigel, Nigel Stallard, Manzoor, Susan, Ala Szczepura, Hardy, Katherine, Helen Parsons, Hawkey, P. M. (Peter M.), Szczepura, Ala; id_orcid   +16 more
core   +1 more source

The human gut microbiome across the life course

FEBS Letters, EarlyView.
Despite significant individual variation and continuous change throughout life, the human gut microbiome follows some life stage‐specific trends. This article provides a brief overview of how gut microbiome composition shifts across different phases of life. Created in BioRender. Özkurt, E. (2026) https://BioRender.com/8q4nrnc.
Alise J. Ponsero, Basak Bahcivanci, Antonietta Hayhoe, Animesh Acharjee, Ezgi Özkurt   +4 more
wiley   +1 more source

Association of tcdB PCR Cycle Threshold with Toxin Antigen Positivity and Clinical Severity in Clostridioides difficile Infection

Korean Journal of Clinical Laboratory Science
Various methods are used to diagnose and evaluate the severity of a Clostridioides difficile infection (CDI). Among them, the correlation between the tcdB gene PCR cycle threshold (Ct) values and toxin antigen detection is a key area of research.
Chan Kyu KIM, Ho-Keun CHOI
doaj   +1 more source

CLOSTRIDIUM DIFFICILE ASSOCIATED DISEASE IN THE NEUROINTENSIVECARE UNIT.

Frontiers in Neurology, 2013
. BACKGROUND- Critically ill patients are at high risk for acquiring Clostridium difficile infection. The aim of this study was to investigate the prevalence, severity and outcome of Neurointensive Care Unit (NICU) acquired Clostridium difficile ...
Swagata eTripathy, Priya eNair, Michael eRothburn, Michael eRothburn   +3 more
doaj   +1 more source

Clostridium perfringens epsilon toxin mutant Y30A-Y196A as a recombinant vaccine candidate against enterotoxemia [PDF]

, 2014
Epsilon toxin (Etx) is a β-pore-forming toxin produced by Clostridium perfringens toxinotypes B and D and plays a key role in the pathogenesis of enterotoxemia, a severe, often fatal disease of ruminants that causes significant economic losses to the ...
Bokori-Brown, M., Moss, David S., Titball, Richard W., Hall, C.A., Hall, CA, Fernandes da Costa, SP, Naylor, Claire, Cole, Ambrose R., Moss, DS, Naylor, Claire E., Fernandes da Costa, Sérgio P., Cole, AR, Hall, Charlotte, Basak, AK, Titball, R.W., Savva, CG, Hall, Charlotte A., Fernandes da Costa, S.P., Titball, Richard, Basak, Ajit K., Bokori-Brown, Monika, Vance, Charlotte, Vance, C, Vance, C., Naylor, CE, Savva, Christos G.   +25 more
core   +1 more source

Human Gut Bacteria and Lipidic Nanoparticles: Particle Composition Predicts Structural Transformation and Bacterial Biocompatibility

Advanced Functional Materials, EarlyView.
Lipidic nanoparticles (LNPs) were incubated with 21 gut bacteria frequently associated with the human microbiome. SAXS revealed that ∼75% of tested species induced structural transformations in monoolein LNPs, whereas phytantriol and phospholipid formulations remained unaffected.
Jonathan Caukwell, Emily L. Gulliver, Livia Salvati Manni, Frithjof Herb, Caitlin Welsh, Samuel C. Forster, Andrew J. Clulow, Wye‐Khay Fong   +7 more
wiley   +1 more source

A Portable Colorimetric Device for Rapid Bacterial Detection with Cleavable Functional Nucleic Acid Probes for A Common Bacterial Endoribonuclease

Angewandte Chemie, EarlyView.
A simple, rapid, and portable gold‐coated filter tip‐based assay (GFTA) is developed for bacterial detection. The GFTA leverages cleavable functional nucleic acid probes as molecular recognition elements to target RNase H2, a highly conserved bacterial endoribonuclease, enabling sensitive and specific colorimetric detection of bacterial pathogens ...
Jiuxing Li, Rudi Liu, Wenqing Zhang, Bruno J. Salena, Yingfu Li   +4 more
wiley   +2 more sources

Recommendations for the management of Clostridioides difficile infection in adults and comparison with updated ACG, ESCMID and IDSA/SHEA guidelines

Family Medicine & Primary Care Review
Clostridioides difficile infection is the most common cause of antibiotic-associated diarrhea. IDSA/SHEA, ESCMID and ACG updated the clinical practice guidelines for CDI in 2021. This paper is an attempt to summarize these guidelines.
Mateusz Piotr Baran, Jarosław Drobnik, Mária Belovičová, Štefánia Moricová, Piotr Pobrotyn   +4 more
doaj   +1 more source

Detection and molecular characterization of Clostridium perfringens, Paeniclostridium sordellii and Clostridium septicum from lambs and goat kids with hemorrhagic abomasitis in Turkey

BMC Veterinary Research, 2023
Background The pathogenic Clostridia cause neurotoxic, histotoxic and enterotoxic infections in humans and animals. Several Clostridium species have been associated with abomasitis in ruminants.
Hakan Kalender, Hasan Öngör, Necati Timurkaan, Burcu Karagülle, Burak Karabulut, Canan Akdeniz İncili, Hatip Enfal Başar, Elif Ekinci, Aydın Çevik, Eray Atıl, Burhan Çetinkaya   +10 more
doaj   +1 more source

Clostridium perfringensepsilon toxin H149A mutant as a platform for receptor binding studies

, 2013
Clostridium perfringens epsilon toxin (Etx) is a pore-forming toxin responsible for a severe and rapidly fatal enterotoxemia of ruminants. The toxin is classified as a category B bioterrorism agent by the U.S.
Titball, R.W., Kokkinidou, Maria C., Richard W. Titball, Bokori-Brown, M., Kokkinidou, M.C., Claire E. Naylor, Fernandes da Costa, S.P., Moss, David S., Titball, Richard W., Monika Bokori‐Brown, Maria C. Kokkinidou, David S. Moss, Basak, Ajit K., Bokori-Brown, Monika, Cole, Ambrose R., Sérgio Fernandes da Costa, Naylor, Claire E., Ambrose R. Cole, Fernandes da Costa, Sérgio P., Christos G. Savva, Ajit K. Basak, Savva, Christos G.   +21 more
core   +1 more source